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> Protein (NX_Q9C0C4)
Protein (NX_Q9C0C4)
Protein
Gene SymbolSEMA4C to neXtProt (NX_Q9C0C4)
DescriptionSemaphorin-4C
Chromosome2
Location2q11.2 (97525453 ~ 97536494) to Ensembl
Sequene Features : Isoforms 1, Variants 87, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 87 16
2014-09-19protein level
1 62 16
2014-05-27protein level
1 62 16
2014-02-25protein level
1 61 16
2013-12-09protein level
1 46 16
2013-11-01protein level
1 45 15
2013-09-12protein level
1 45 15
2013-08-17protein level
1 45 15
2013-07-15protein level
1 24 15
2013-06-11protein level
1 24 15
2013-02-12protein level
1 17 15
2012-12-20protein level
1 16 15
2012-10-30protein level
1 16 15
2012-10-07protein level
1 16 15
2012-08-24protein level
1 12 15
2012-07-28protein level
1 12 15
2012-06-08protein level
1 13 15
2012-05-07protein level
1 12 15
2012-04-10protein level
1 12 15
2012-01-13protein level
1 7 13
2011-12-20protein level
1 7 13
2011-11-11protein level
1 7 12
2011-08-23protein level
1 7 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9C0C4-1
40 0 0 92563.6248
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10303490,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
2 EBI-10303490,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
3 EBI-10303490,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
4 EBI-10303490,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
5 EBI-10303490,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone27
brain28
embryonic tissue93
eye43
intestine4
kidney9
liver29
lung29
lymph22
mammary gland46
mouth15
muscle122
nerve64
ovary49
pancreas14
pharynx24
placenta38
prostate26
skin9
spleen56
stomach20
testis9
thyroid21
uterus25
vascular19
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor64
chondrosarcoma36
gastrointestinal tumor16
germ cell tumor53
glioma37
head and neck tumor14
kidney tumor14
leukemia10
liver tumor62
lung tumor38
lymphoma13
non-neoplasia20
ovarian tumor26
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma43
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult23
embryoid body85
blastocyst179
fetus17
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.4
adrenal gland9.6
appendix11.3
bone marrow3.5
cerebral cortex19.1
colon8.7
duodenum7.3
esophagus12.4
gallbladder16.8
heart muscle13.4
kidney9.4
liver5
lung14.6
lymph node10.3
ovary19.5
pancreas4.8
placenta41.5
prostate21.8
salivary gland12.2
skin17.7
small intestine7.7
spleen32.2
stomach7.4
testis4.4
thyroid gland6.6
urinary bladder18.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(-604462, phenotype) Semaphorin 4c; SEMA4COMIM


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