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> Protein (NX_Q9C0C9)
Protein (NX_Q9C0C9)
Protein
Gene SymbolUBE2O to neXtProt (NX_Q9C0C9)
DescriptionE2/E3 hybrid ubiquitin-protein ligase UBE2O
Chromosome17
Location17q25.1 (74385532 ~ 74449288) to Ensembl
Sequene Features : Isoforms 1, Variants 121, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K63-linked ubiquitination
.retrograde transport, endosome to Golgi
.positive regulation of BMP signaling pathway
.protein monoubiquitination
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.poly(A) RNA binding
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 121 23
2014-09-19protein level
1 88 23
2014-05-27protein level
1 88 23
2014-02-25protein level
1 85 23
2013-12-09protein level
1 69 23
2013-11-01protein level
1 65 16
2013-09-12protein level
1 65 16
2013-08-17protein level
1 65 16
2013-07-15protein level
1 42 12
2013-06-11protein level
1 42 12
2013-02-12protein level
1 19 12
2012-12-20protein level
1 19 12
2012-10-30protein level
1 20 12
2012-10-07protein level
1 20 12
2012-08-24protein level
1 12 12
2012-07-28protein level
1 12 12
2012-06-08protein level
1 19 12
2012-05-07protein level
1 19 12
2012-04-10protein level
1 19 12
2012-01-13protein level
1 13 12
2011-12-20protein level
1 13 12
2011-11-11protein level
1 13 12
2011-08-23protein level
1 13 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9C0C9-1
56 0 0 141204.6228
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2339946,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood24
bone13
brain63
cervix20
connective tissue13
embryonic tissue51
eye67
heart33
intestine47
kidney56
larynx85
liver68
lung32
lymph45
lymph node55
mammary gland26
mouth60
muscle37
nerve64
ovary59
pancreas56
pituitary gland60
placenta42
prostate89
salivary gland49
skin99
stomach31
testis45
thymus12
thyroid21
umbilical cord72
uterus25
vascular19
Health State
TissuesTPM*
normal38
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma12
colorectal tumor62
gastrointestinal tumor42
germ cell tumor56
glioma46
head and neck tumor59
kidney tumor72
leukemia21
liver tumor135
lung tumor68
lymphoma27
non-neoplasia51
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS188
prostate cancer154
retinoblastoma64
skin tumor151
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult37
embryoid body57
blastocyst81
neonate32
fetus57
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.2
adrenal gland6.9
appendix13
bone marrow13.8
cerebral cortex21.3
colon6.6
duodenum8.4
esophagus10.1
gallbladder6.5
heart muscle12.7
kidney6.2
liver3.3
lung7.3
lymph node13.5
ovary13.1
pancreas7.2
placenta9.7
prostate9
salivary gland9.9
skin12.1
small intestine7.7
spleen12.2
stomach10.7
testis18.4
thyroid gland17.4
urinary bladder8.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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