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> Protein (NX_Q9GZQ8)
Protein (NX_Q9GZQ8)
Protein
Gene SymbolMAP1LC3B to neXtProt (NX_Q9GZQ8)
DescriptionMicrotubule-associated proteins 1A/1B light chain 3B
Chromosome16
Location16q24.2 (87417601 ~ 87438385) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 2
2014-09-19protein level
1 13 2
2014-05-27protein level
1 13 4
2014-02-25protein level
1 13 4
2013-12-09protein level
1 9 4
2013-11-01protein level
1 9 2
2013-09-12protein level
1 9 2
2013-08-17protein level
1 9 2
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 4 1
2012-10-07protein level
1 4 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 7 1
2012-05-07protein level
1 7 1
2012-04-10protein level
1 7 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9GZQ8-1
1 0 2 14678.6731
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373144,EBI-356424 IPO5  
  .cellular response to amino acid stimulus
.positive regulation of protein import into nucleus
.negative regulation of GTPase activity
  + 3 more...
.poly(A) RNA binding
.protein transporter activity
.Ran GTPase binding
.GTPase inhibitor activity
.intracellular membrane-bounded organelle
.nuclear membrane
.membrane
  + 6 more...
2 EBI-373144,EBI-2798775 ATG13  
  .positive regulation of protein targeting to mitochondrion
.activation of mitophagy in response to mitochondrial depolarization
.autophagic vacuole assembly
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.cytosol
  + 2 more...
3 EBI-373144,EBI-307133 GBAS  
  .negative regulation of ATP citrate synthase activity
.ATP biosynthetic process
.oxidative phosphorylation
.N/A .membrane
.integral component of plasma membrane
.mitochondrion
4 EBI-373144,EBI-908831 ULK1  
  .regulation of neurotrophin TRK receptor signaling pathway
.axon extension
.negative regulation of collateral sprouting
  + 15 more...
.protein complex binding
.Rab GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.extrinsic component of autophagic vacuole membrane
.extrinsic component of pre-autophagosomal structure membrane
.extrinsic component of omegasome membrane
  + 9 more...
5 EBI-373144,EBI-2947137 STBD1  
  .muscle contraction .starch binding .membrane
.integral component of plasma membrane
6 EBI-373144,EBI-987834 ATG7  
  .negative regulation of histone H4-K16 acetylation
.regulation of mitochondrion degradation
.cellular response to hyperoxia
  + 33 more...
.protein homodimerization activity
.Atg8 activating enzyme activity
.Atg12 activating enzyme activity
  + 2 more...
.axoneme
.cytosol
.cytoplasm
.pre-autophagosomal structure
7 EBI-373144,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
8 EBI-373144,EBI-356720 HADHA  
  .glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 5 more...
.NAD binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
.long-chain-enoyl-CoA hydratase activity
  + 4 more...
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
.mitochondrial inner membrane
.mitochondrion
9 EBI-373144,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-373144,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
11 EBI-373144,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
12 EBI-373144,EBI-352869 SAFB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
13 EBI-373144,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
14 EBI-373144,EBI-1171113 CLINT1  
  .membrane organization
.clathrin coat assembly
.endocytosis
.post-Golgi vesicle-mediated transport
.clathrin binding
.lipid binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.clathrin-coated vesicle
  + 4 more...
15 EBI-373144,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
16 EBI-373144,EBI-348298 SAFB  
  .positive regulation of transcription from RNA polymerase II promoter
.hormone metabolic process
.growth
  + 3 more...
.poly(A) RNA binding
.double-stranded DNA binding
.chromatin binding
  + 2 more...
.nucleoplasm
.nucleus
17 EBI-373144,EBI-2514077 ATG2A  
  .nucleophagy
.cellular response to nitrogen starvation
.mitochondrion degradation
.autophagic vacuole assembly
.N/A .pre-autophagosomal structure membrane
.extrinsic component of membrane
.lipid particle
.pre-autophagosomal structure
18 EBI-373144,EBI-535909 ATG16L1  
  .protein homooligomerization
.negative stranded viral RNA replication
.protein transport
.autophagic vacuole assembly
.identical protein binding .pre-autophagosomal structure membrane
.axoneme
.autophagic vacuole
.autophagic vacuole membrane
19 EBI-373144,EBI-2514778 KBTBD6  
  .N/A .N/A .N/A
20 EBI-373144,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
21 EBI-373144,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
22 EBI-373144,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
23 EBI-373144,EBI-1044009 NEK9  
  .cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
24 EBI-373144,EBI-473695 KBTBD7  
  .N/A .N/A .N/A
25 EBI-373144,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
26 EBI-373144,EBI-739657 KXD1  
  .vesicle-mediated transport .N/A .BLOC-1 complex
27 EBI-373144,EBI-2869338 FYCO1  
  .plus-end-directed vesicle transport along microtubule .metal ion binding .cytoplasmic vesicle
.integral component of membrane
.membrane
  + 3 more...
28 EBI-373144,EBI-2846068 PINK1  
  .positive regulation of ATP biosynthetic process
.negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
  + 58 more...
.C3HC4-type RING finger domain binding
.protein kinase B binding
.ubiquitin protein ligase binding
  + 7 more...
.astrocyte projection
.Lewy body
.perinuclear region of cytoplasm
  + 13 more...
29 EBI-373144,EBI-747805 UBA5  
  .protein polyufmylation
.protein ufmylation
.response to endoplasmic reticulum stress
.regulation of intracellular estrogen receptor signaling pathway
.UFM1 activating enzyme activity
.metal ion binding
.ATP binding
.intracellular membrane-bounded organelle
.cytosol
.cytoplasm
.nucleus
30 EBI-373144,EBI-1047414 ATG5  
  .negative regulation of histone H4-K16 acetylation
.regulation of reactive oxygen species metabolic process
.regulation of cilium assembly
  + 23 more...
.N/A .ER-mitochondrion membrane contact site
.Atg12-Atg5-Atg16 complex
.pre-autophagosomal structure membrane
  + 4 more...
31 EBI-373144,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
32 EBI-373144,EBI-367363 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
33 EBI-373144,EBI-988094 ATG3  
  .regulation of cilium assembly
.nucleophagy
.mitochondrial fragmentation involved in apoptotic process
  + 5 more...
.enzyme binding
.ubiquitin-like protein transferase activity
.Atg12 transferase activity
  + 2 more...
.cytosol
.cytoplasmic ubiquitin ligase complex
34 EBI-373144,EBI-2947180 TBC1D2B  
  .N/A .GTPase activator activity .N/A
35 EBI-373144,EBI-352851 LUC7L2  
  .mRNA splice site selection .poly(A) RNA binding
.enzyme binding
.mRNA binding
.nuclear speck
.U1 snRNP
36 EBI-373144,EBI-712014 ATG4B  
  .protein delipidation
.positive regulation of protein catabolic process
.nucleophagy
  + 9 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.endopeptidase activity
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland151
ascites200
bladder200
blood114
bone153
bone marrow205
brain296
cervix123
connective tissue140
ear62
embryonic tissue108
eye177
heart435
intestine142
kidney227
liver58
lung137
lymph22
lymph node55
mammary gland112
mouth120
muscle47
nerve128
ovary59
pancreas168
parathyroid534
pharynx49
pituitary gland60
placenta314
prostate121
salivary gland49
skin223
spleen243
stomach104
testis195
thymus351
thyroid214
trachea115
umbilical cord72
uterus180
vascular561
Health State
TissuesTPM*
normal237
adrenal tumor158
breast (mammary gland) tumor128
cervical tumor173
chondrosarcoma120
colorectal tumor88
gastrointestinal tumor109
germ cell tumor387
glioma279
head and neck tumor112
kidney tumor275
leukemia52
liver tumor83
lung tumor38
lymphoma27
non-neoplasia144
ovarian tumor65
pancreatic tumor247
primitive neuroectodermal tumor of the CNS70
prostate cancer86
retinoblastoma150
skin tumor55
soft tissue/muscle tissue tumor71
uterine tumor77
Developmental Stage
TissuesTPM*
adult184
embryoid body128
blastocyst48
neonate225
fetus211
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue52.7
adrenal gland60
appendix27.8
bone marrow108.9
cerebral cortex60.1
colon31.3
duodenum16.2
esophagus33.6
gallbladder44.2
heart muscle55.2
kidney31.6
liver19.9
lung32.5
lymph node36.3
ovary30.7
pancreas12.5
placenta51.6
prostate28.5
salivary gland24.6
skin29.9
small intestine20.9
spleen29.2
stomach24.3
testis42.9
thyroid gland46.6
urinary bladder44.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609604, gene) Microtubule-associated protein 1, light chain 3, beta; MAP1LC3BOMIM


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