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> Protein (NX_Q9GZT8)
Protein (NX_Q9GZT8)
Protein
Gene SymbolNIF3L1 to neXtProt (NX_Q9GZT8)
DescriptionPutative GTP cyclohydrolase 1 type 2 NIF3L1
Chromosome2
Location2q33.1 (201754050 ~ 201768655) to Ensembl
Sequene Features : Isoforms 3, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 54 6
2014-09-19protein level
3 39 6
2014-05-27protein level
3 38 6
2014-02-25protein level
3 37 6
2013-12-09protein level
3 21 6
2013-11-01protein level
3 21 3
2013-09-12protein level
3 21 3
2013-08-17protein level
3 21 3
2013-07-15protein level
3 17 2
2013-06-11protein level
3 17 2
2013-02-12protein level
3 7 5
2012-12-20protein level
3 6 5
2012-10-30protein level
3 10 5
2012-10-07protein level
3 10 2
2012-08-24protein level
3 10 2
2012-07-28protein level
3 10 2
2012-06-08protein level
3 12 2
2012-05-07protein level
3 10 2
2012-04-10protein level
2 8 2
2012-01-13protein level
2 4 2
2011-12-20protein level
2 4 2
2011-11-11protein level
2 4 1
2011-08-23protein level
2 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9GZT8-1
0 17 0 41941.3849
NX_Q9GZT8-2
0 15 0 38958.9056
NX_Q9GZT8-3
4 12 0 32143.4922
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740897,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
2 EBI-740897,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
3 EBI-740897,EBI-536866 NUDT14  
  .N/A .ADP-ribose diphosphatase activity
.metal ion binding
.UDP-sugar diphosphatase activity
.extracellular exosome
.cytoplasm
4 EBI-740897,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
5 EBI-740897,EBI-10196922 SULT1A3  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 7 more...
.sulfotransferase activity
.aryl sulfotransferase activity
.cytosol
6 EBI-740897,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
7 EBI-740897,EBI-711280 CDKN2B  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of protein serine/threonine kinase activity
.negative regulation of epithelial cell proliferation
  + 22 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-740897,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
9 EBI-740897,EBI-741925 DHPS  
  .protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
10 EBI-740897,EBI-6137631 SULT1A2  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 5 more...
.flavonol 3-sulfotransferase activity
.sulfotransferase activity
.aryl sulfotransferase activity
.cytosol
11 EBI-740897,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
12 EBI-740897,EBI-743027 DYNLT3  
  .cell division
.regulation of mitotic cell cycle
.mitotic nuclear division
.transport
.motor activity .microtubule
.cytoplasmic dynein complex
.nucleus
.condensed chromosome kinetochore
13 EBI-740897,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
14 EBI-740897,EBI-930865 DMC1  
  .female gamete generation
.spermatid development
.spermatogenesis
  + 7 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.chromosome
.nucleus
.condensed nuclear chromosome
.chromosome, telomeric region
15 EBI-740897,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
16 EBI-740897,EBI-5917279 AP5B1  
  .endosomal transport
.protein transport
.N/A .AP-type membrane coat adaptor complex
.lysosomal membrane
17 EBI-740897,EBI-10258086 ARPIN  
  .negative regulation of lamellipodium morphogenesis
.negative regulation of actin nucleation
.directional locomotion
.negative regulation of cell migration
.N/A .lamellipodium
18 EBI-740897,EBI-8656665 NATD1  
  .N/A .N/A .N/A
19 EBI-740897,EBI-743382 BEND7  
  .N/A .N/A .extracellular exosome
20 EBI-740897,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
21 EBI-740897,EBI-724940 DUSP23  
  .N/A .protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.cytosol
.nucleus
22 EBI-740897,EBI-748028 EIF5A2  
  .mRNA transport
.positive regulation of translational termination
.positive regulation of translational elongation
  + 8 more...
.ribosome binding
.translation elongation factor activity
.cytosol
.endoplasmic reticulum membrane
.nuclear pore
23 EBI-740897,EBI-1055930 FAM49B  
  .N/A .N/A .extracellular exosome
.cilium
24 EBI-740897,EBI-1038192 LAMTOR3  
  .cellular response to amino acid stimulus
.positive regulation of GTPase activity
.cellular protein localization
.positive regulation of TOR signaling
.N/A .Ragulator complex
.extracellular exosome
.focal adhesion
25 EBI-740897,EBI-10303987 DCDC2  
  .dendrite morphogenesis
.positive regulation of smoothened signaling pathway
.intracellular signal transduction
  + 4 more...
.N/A .primary cilium
.axoneme
.cytoplasm
26 EBI-740897,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder33
blood40
bone83
bone marrow20
brain33
cervix41
connective tissue100
embryonic tissue65
esophagus49
eye71
heart11
intestine47
kidney42
liver34
lung56
lymph node66
mammary gland59
muscle56
ovary157
pancreas42
parathyroid48
pharynx147
pituitary gland60
placenta81
prostate15
salivary gland49
skin56
stomach73
testis22
thymus25
tonsil646
uterus81
Health State
TissuesTPM*
normal53
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma72
colorectal tumor53
gastrointestinal tumor75
germ cell tumor56
glioma37
kidney tumor58
leukemia21
liver tumor41
lung tumor77
lymphoma55
non-neoplasia41
ovarian tumor157
pancreatic tumor28
primitive neuroectodermal tumor of the CNS133
retinoblastoma43
skin tumor79
soft tissue/muscle tissue tumor175
uterine tumor88
Developmental Stage
TissuesTPM*
adult52
embryoid body114
blastocyst48
fetus59
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.5
adrenal gland18.8
appendix14.1
bone marrow6.9
cerebral cortex16.5
colon18.6
duodenum14
esophagus15.8
gallbladder12.4
heart muscle16.4
kidney17.8
liver10.6
lung12.8
lymph node22.7
ovary19.7
pancreas5.6
placenta18.5
prostate14.2
salivary gland13.8
skin15.8
small intestine14.3
spleen15.4
stomach15.8
testis17
thyroid gland18.1
urinary bladder20.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605778, gene) Nif3-like 1; NIF3L1OMIM


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2014-2019 (C) Yonsei Proteome Research Center