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> Protein (NX_Q9GZV8)
Protein (NX_Q9GZV8)
Gene SymbolPRDM14 to neXtProt (NX_Q9GZV8)
DescriptionPR domain zinc finger protein 14
Location8q13.3 (70963886 ~ 70983928) to Ensembl
Sequene Features : Isoforms 1, Variants 103, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 103 2
2014-09-19protein level
1 73 2
2014-05-27protein level
1 73 2
2014-02-25protein level
1 73 2
2013-12-09protein level
1 69 2
2013-11-01protein level
1 67 2
2013-09-12protein level
1 67 2
2013-08-17protein level
1 67 2
2013-07-15protein level
1 36 2
2013-06-11protein level
1 36 2
2013-02-12protein level
1 12 2
2012-12-20protein level
1 12 2
2012-10-30protein level
1 14 2
2012-10-07protein level
1 14 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 4 2
2011-12-20protein level
1 4 2
2011-11-11protein level
1 4 2
2011-08-23protein level
1 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
27 0 0 64020.7593
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3957793,EBI-748628 CBFA2T2  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.epithelial cell differentiation
  + 2 more...
.metal ion binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
2 EBI-3957793,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
3 EBI-3957793,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
  + 3 more...
4 EBI-3957793,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
  + 7 more...
5 EBI-3957793,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
6 EBI-3957793,EBI-8636434 TTC32  
  .N/A .N/A .N/A
7 EBI-3957793,EBI-10244342 MIA3  
  .wound healing
.positive regulation of bone mineralization
.negative regulation of cell migration
  + 6 more...
.N/A .intracellular membrane-bounded organelle
.integral component of membrane
.endoplasmic reticulum membrane
8 EBI-3957793,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
9 EBI-3957793,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
10 EBI-3957793,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
11 EBI-3957793,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
12 EBI-3957793,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
13 EBI-3957793,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
14 EBI-3957793,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
15 EBI-3957793,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
16 EBI-3957793,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
embryonic tissue28
Health State
germ cell tumor3
Developmental Stage
embryoid body14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*611781, gene) Pr domain-containing protein 14; PRDM14OMIM

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