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> Protein (NX_Q9GZX7)
Protein (NX_Q9GZX7)
Protein
Gene SymbolAICDA to neXtProt (NX_Q9GZX7)
DescriptionSingle-stranded DNA cytosine deaminase
Chromosome12
Location12p13.31 (8754762 ~ 8765467) to Ensembl
Sequene Features : Isoforms 2, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of methylation-dependent chromatin silencing
.DNA demethylation
.cellular response to lipopolysaccharide
  + 5 more...
.ubiquitin protein ligase binding
.zinc ion binding
.cytidine deaminase activity
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 50 2
2014-09-19protein level
2 40 2
2014-05-27protein level
2 40 2
2014-02-25protein level
2 40 2
2013-12-09protein level
2 35 2
2013-11-01protein level
2 34 2
2013-09-12protein level
2 34 2
2013-08-17protein level
1 34 2
2013-07-15protein level
1 25 2
2013-06-11protein level
1 25 2
2013-02-12protein level
1 12 1
2012-12-20protein level
1 11 1
2012-10-30protein level
1 11 1
2012-10-07protein level
1 11 1
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9GZX7-1
1 10 0 23938.0633
NX_Q9GZX7-2
0 10 0 22599.5284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3834328,EBI-352957 DNAJA2  
  .protein refolding
.response to heat
.positive regulation of cell proliferation
.chaperone binding
.unfolded protein binding
.metal ion binding
.ATP binding
.extracellular exosome
.membrane
.cytosol
2 EBI-3834328,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
3 EBI-3834328,EBI-448167 GADD45A  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of p38MAPK cascade
.mitotic cell cycle arrest
  + 12 more...
.core promoter binding .cytoplasm
.nucleus
4 EBI-3834328,EBI-347834 DNAJA1  
  .toxin transport
.protein localization to mitochondrion
.regulation of protein transport
  + 12 more...
.C3HC4-type RING finger domain binding
.chaperone binding
.unfolded protein binding
  + 6 more...
.cytoplasmic side of endoplasmic reticulum membrane
.extracellular exosome
.perinuclear region of cytoplasm
  + 4 more...
5 EBI-3834328,EBI-348333 TDG  
  .DNA demethylation
.depyrimidination
.cellular protein metabolic process
  + 14 more...
.structure-specific DNA binding
.protein homodimerization activity
.mismatched DNA binding
  + 5 more...
.PML body
.plasma membrane
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
kidney9
lymph45
lymph node44
pancreas4
pharynx24
testis2
tonsil940
Health State
TissuesTPM*
normal8
kidney tumor29
lymphoma138
Developmental Stage
TissuesTPM*
fetus10
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.4
lymph node15.3
spleen1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605257, gene) Activation-induced cytidine deaminase; AICDAOMIM
2(#605258, phenotype) Immunodeficiency with hyper-igm, type 2; HIGM2OMIM


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