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> Protein (NX_Q9H000)
Protein (NX_Q9H000)
Protein
Gene SymbolMKRN2 to neXtProt (NX_Q9H000)
DescriptionProbable E3 ubiquitin-protein ligase makorin-2
Chromosome3
Location3p25.2 (12598513 ~ 12625212) to Ensembl
Sequene Features : Isoforms 2, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 43 3
2014-09-19protein level
2 31 3
2014-05-27protein level
1 31 3
2014-02-25protein level
1 31 3
2013-12-09protein level
1 24 3
2013-11-01protein level
1 21 3
2013-09-12protein level
1 21 3
2013-08-17protein level
1 21 3
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 7 1
2012-12-20protein level
1 6 1
2012-10-30protein level
1 8 1
2012-10-07protein level
1 8 1
2012-08-24protein level
1 8 1
2012-07-28protein level
1 8 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 6 1
2012-04-10protein level
1 6 1
2012-01-13protein level
1 6 1
2011-12-20protein level
1 6 1
2011-11-11protein level
1 6 1
2011-08-23protein level
1 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H000-1
3 19 0 46909.2816
NX_Q9H000-2
0 19 0 41957.0625
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2341005,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-2341005,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
3 EBI-2341005,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
4 EBI-2341005,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder33
blood49
bone41
bone marrow225
brain87
cervix61
connective tissue80
ear124
embryonic tissue56
esophagus49
eye76
heart33
intestine64
kidney61
liver38
lung20
lymph22
lymph node55
mammary gland26
mouth60
muscle9
nerve64
ovary9
pancreas42
pharynx24
placenta35
prostate10
skin90
spleen37
stomach83
testis204
thymus100
thyroid64
trachea57
umbilical cord72
uterus77
vascular19
Health State
TissuesTPM*
normal60
adrenal tumor237
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma72
colorectal tumor115
esophageal tumor57
gastrointestinal tumor59
germ cell tumor87
glioma55
head and neck tumor52
kidney tumor58
leukemia116
liver tumor62
lung tumor19
lymphoma27
non-neoplasia113
pancreatic tumor28
primitive neuroectodermal tumor of the CNS78
retinoblastoma129
skin tumor87
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult45
embryoid body42
blastocyst65
neonate128
fetus73
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.5
adrenal gland13.1
appendix14.3
bone marrow12.4
cerebral cortex21.8
colon13.9
duodenum14.9
esophagus19.8
gallbladder14.5
heart muscle27.2
kidney16.4
liver8.3
lung15.6
lymph node17.3
ovary24.6
pancreas12.4
placenta17.4
prostate13.9
salivary gland11.5
skin14.6
small intestine12.5
spleen12.7
stomach12.6
testis54.1
thyroid gland24.9
urinary bladder18.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608426, gene) Makorin 2; MKRN2OMIM


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