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> Protein (NX_Q9H0E2)
Protein (NX_Q9H0E2)
Protein
Gene SymbolTOLLIP to neXtProt (NX_Q9H0E2)
DescriptionToll-interacting protein
Chromosome11
Location11p15.5 (1295601 ~ 1330884) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.leukocyte activation
.innate immune response
.protein localization to endosome
  + 8 more...
.Toll-like receptor binding
.kinase binding
.signal transducer activity
.extracellular exosome
.perinuclear region of cytoplasm
.interleukin-1 receptor complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 7
2014-09-19protein level
1 31 7
2014-05-27protein level
1 31 7
2014-02-25protein level
1 29 7
2013-12-09protein level
1 24 7
2013-11-01protein level
1 24 6
2013-09-12protein level
1 24 5
2013-08-17protein level
1 24 5
2013-07-15protein level
1 15 1
2013-06-11protein level
1 15 1
2013-02-12protein level
1 9 3
2012-12-20protein level
1 8 3
2012-10-30protein level
1 8 3
2012-10-07protein level
1 8 3
2012-08-24protein level
1 7 3
2012-07-28protein level
1 7 3
2012-06-08protein level
1 9 3
2012-05-07protein level
1 9 3
2012-04-10protein level
1 9 3
2012-01-13protein level
1 7 3
2011-12-20protein level
1 7 3
2011-11-11protein level
1 7 3
2011-08-23protein level
1 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H0E2-1
5 6 0 30262.0876
NX_Q9H0E2-2
0 6 0 22797.1615
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-74615,EBI-447733 IRAK2  
  .response to interleukin-1
.interleukin-1-mediated signaling pathway
.nucleotide-binding oligomerization domain containing signaling pathway
  + 25 more...
.protein heterodimerization activity
.protein homodimerization activity
.ATP binding
.protein serine/threonine kinase activity
.interleukin-1 receptor complex
.endosome membrane
.plasma membrane
  + 3 more...
2 EBI-74615,EBI-74634 TOM1  
  .endosomal transport
.protein transport
.endocytosis
.intracellular protein transport
.clathrin binding .extracellular exosome
.membrane
.cytosol
  + 3 more...
3 EBI-74615,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
4 EBI-74615,EBI-712991 TOM1L1  
  .negative regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.activation of protein kinase activity
  + 3 more...
.ubiquitin binding
.protein kinase activator activity
.clathrin binding
.protein kinase binding
.extracellular exosome
.endosome membrane
.cytosol
  + 4 more...
5 EBI-74615,EBI-640775 EIF2AK2  
  .regulation of hematopoietic stem cell differentiation
.regulation of hematopoietic stem cell proliferation
.regulation of hematopoietic progenitor cell differentiation
  + 27 more...
.poly(A) RNA binding
.protein phosphatase type 2A regulator activity
.ATP binding
  + 5 more...
.perinuclear region of cytoplasm
.membrane
.ribosome
  + 3 more...
6 EBI-74615,EBI-1789619 CSTF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 6 more...
.poly(A) RNA binding
.RNA binding
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-74615,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
8 EBI-74615,EBI-2858265 PEG10  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.cell differentiation
.apoptotic process
.poly(A) RNA binding
.zinc ion binding
.DNA binding
.cytoplasm
.nucleus
9 EBI-74615,EBI-948630 DZIP3  
  .protein polyubiquitination .poly(A) RNA binding
.polyubiquitin binding
.phosphatase binding
  + 4 more...
.cytoplasm
10 EBI-74615,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
11 EBI-74615,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
12 EBI-74615,EBI-2513471 WRNIP1  
  .regulation of DNA-dependent DNA replication initiation
.DNA replication
.DNA synthesis involved in DNA repair
.metal ion binding
.identical protein binding
.ATPase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane
.nucleus
13 EBI-74615,EBI-720768 MAP1LC3A  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.phosphatidylethanolamine binding
.microtubule binding
.phospholipid binding
.cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites100
bladder33
blood57
bone83
bone marrow20
brain272
cervix20
connective tissue53
embryonic tissue32
eye86
heart22
intestine64
kidney80
liver34
lung77
lymph22
lymph node22
mammary gland39
mouth75
muscle37
ovary9
pancreas89
parathyroid97
pharynx73
placenta63
prostate89
salivary gland296
skin147
spleen74
testis190
thymus50
thyroid42
trachea135
uterus56
vascular38
Health State
TissuesTPM*
normal133
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma60
colorectal tumor53
gastrointestinal tumor42
germ cell tumor68
glioma102
head and neck tumor119
kidney tumor43
leukemia105
liver tumor52
lung tumor38
lymphoma27
non-neoplasia62
ovarian tumor13
pancreatic tumor66
primitive neuroectodermal tumor of the CNS15
prostate cancer115
retinoblastoma86
skin tumor119
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult78
embryoid body14
blastocyst32
fetus71
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.9
adrenal gland19.5
appendix11.8
bone marrow10.8
cerebral cortex61.4
colon15.2
duodenum18.9
esophagus31.8
gallbladder18.6
heart muscle16.3
kidney33.9
liver28.6
lung16.3
lymph node13
ovary13.9
pancreas26.4
placenta12.1
prostate21.7
salivary gland16.4
skin26.1
small intestine17.5
spleen18.7
stomach18.6
testis44.8
thyroid gland17.6
urinary bladder18.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeLow
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606277, gene) Toll-interacting protein; TOLLIPOMIM


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