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> Protein (NX_Q9H0H5)
Protein (NX_Q9H0H5)
Protein
Gene SymbolRACGAP1 to neXtProt (NX_Q9H0H5)
DescriptionRac GTPase-activating protein 1
Chromosome12
Location12q13.12 (50370706 ~ 50426919) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMs 33 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of attachment of spindle microtubules to kinetochore
.mitotic spindle midzone assembly
.regulation of small GTPase mediated signal transduction
  + 12 more...
.beta-tubulin binding
.metal ion binding
.gamma-tubulin binding
  + 5 more...
.centralspindlin complex
.mitotic spindle
.extracellular exosome
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 33
2014-09-19protein level
1 42 33
2014-05-27protein level
1 42 33
2014-02-25protein level
1 42 33
2013-12-09protein level
1 30 33
2013-11-01protein level
1 28 29
2013-09-12protein level
1 28 28
2013-08-17protein level
1 28 28
2013-07-15protein level
1 19 26
2013-06-11protein level
1 19 26
2013-02-12protein level
1 11 32
2012-12-20protein level
1 10 32
2012-10-30protein level
1 17 31
2012-10-07protein level
1 17 31
2012-08-24protein level
1 15 31
2012-07-28protein level
1 15 31
2012-06-08protein level
1 23 31
2012-05-07protein level
1 23 31
2012-04-10protein level
1 23 31
2012-01-13protein level
1 9 31
2011-12-20protein level
1 9 31
2011-11-11protein level
1 8 28
2011-08-23protein level
1 4 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H0H5-1
29 0 0 70981.5586
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717233,EBI-7942186 RAB11FIP3  
  .negative regulation of adiponectin secretion
.endocytic recycling
.vesicle-mediated transport
  + 2 more...
.protein homodimerization activity
.ADP-ribosylation factor binding
.Rab GTPase binding
.calcium ion binding
.recycling endosome membrane
.recycling endosome
.intercellular bridge
  + 9 more...
2 EBI-717233,EBI-306852 KIF23  
  .mitotic spindle midzone assembly
.positive regulation of cytokinesis
.antigen processing and presentation of exogenous peptide antigen via MHC class II
  + 7 more...
.ATPase activity
.microtubule binding
.ATP binding
.microtubule motor activity
.centralspindlin complex
.mitotic spindle
.intercellular bridge
  + 9 more...
3 EBI-717233,EBI-968374 PPP2R5E  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.protein phosphatase type 2A regulator activity .cytoplasm
.protein phosphatase type 2A complex
4 EBI-717233,EBI-1792052 SLC26A8  
  .chloride transmembrane transport
.sulfate transmembrane transport
.meiotic cell cycle
  + 7 more...
.oxalate transmembrane transporter activity
.anion:anion antiporter activity
.sulfate transmembrane transporter activity
  + 2 more...
.integral component of membrane
.plasma membrane
5 EBI-717233,EBI-1054039 ECT2  
  .apoptotic signaling pathway
.activation of GTPase activity
.cellular response to ionizing radiation
  + 19 more...
.protein homodimerization activity
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.signal transducer activity
.centralspindlin complex
.mitotic spindle
.intracellular membrane-bounded organelle
  + 8 more...
6 EBI-717233,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder100
blood49
bone41
bone marrow20
brain49
cervix164
connective tissue40
embryonic tissue75
esophagus49
eye28
heart145
intestine47
kidney61
liver29
lung50
lymph112
lymph node22
mammary gland99
mouth75
muscle9
ovary29
pancreas9
parathyroid145
pharynx24
placenta63
prostate31
salivary gland148
skin52
testis179
thymus276
tonsil58
trachea19
uterus56
vascular19
Health State
TissuesTPM*
normal40
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor150
cervical tumor231
chondrosarcoma36
colorectal tumor44
esophageal tumor57
germ cell tumor125
glioma149
head and neck tumor37
kidney tumor87
leukemia42
liver tumor62
lung tumor19
lymphoma138
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS86
prostate cancer48
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor87
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body142
blastocyst48
neonate64
fetus73
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.3
adrenal gland2.6
appendix14.1
bone marrow23.6
cerebral cortex8.7
colon15.6
duodenum8.5
esophagus18.6
gallbladder6.2
heart muscle2.2
kidney4.7
liver2.7
lung5.5
lymph node22.8
ovary2.3
pancreas1.9
placenta14.6
prostate3.5
salivary gland1.7
skin11.7
small intestine10.4
spleen6.3
stomach9.8
testis42.9
thyroid gland3.7
urinary bladder11
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderLow
kidneyMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
placentaMedium
rectumMedium
skin 1Medium
skin 2Medium
small intestineMedium
stomach 1Medium
stomach 2Medium
testisHigh
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604980, gene) Gtpase-activating protein, rac, 1; RACGAP1OMIM


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