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> Protein (NX_Q9H0I2)
Protein (NX_Q9H0I2)
Protein
Gene SymbolENKD1 to neXtProt (NX_Q9H0I2)
DescriptionEnkurin domain-containing protein 1
Chromosome16
Location16q22.1 (67696848 ~ 67701168) to Ensembl
Sequene Features : Isoforms 2, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 19 0
2014-09-19protein level
2 35 0
2014-05-27protein level
2 35 0
2014-02-25protein level
2 35 0
2013-12-09protein level
2 25 0
2013-11-01protein level
2 25 0
2013-09-12protein level
2 25 0
2013-08-17protein level
2 25 0
2013-07-15protein level
2 19 0
2013-06-11protein level
2 19 0
2013-02-12protein level
2 9 0
2012-12-20protein level
2 10 0
2012-10-30protein level
2 11 0
2012-10-07protein level
2 11 0
2012-08-24transcript level
2 11 0
2012-07-28transcript level
2 11 0
2012-06-08transcript level
2 0 0
2012-05-07transcript level
2 0 0
2012-04-10transcript level
2 0 0
2012-01-13transcript level
2 0 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H0I2-1
8 9 0 38735.2158
NX_Q9H0I2-2
1 9 0 25530.3116
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744099,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-744099,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
3 EBI-744099,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
4 EBI-744099,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
5 EBI-744099,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-744099,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
7 EBI-744099,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
8 EBI-744099,EBI-10246318 FAM102A  
  .N/A .N/A .N/A
9 EBI-744099,EBI-3937206 SPSB3  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
10 EBI-744099,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
11 EBI-744099,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
12 EBI-744099,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
13 EBI-744099,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
14 EBI-744099,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
15 EBI-744099,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
16 EBI-744099,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
17 EBI-744099,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
18 EBI-744099,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood65
bone69
bone marrow20
brain15
cervix103
connective tissue13
embryonic tissue18
eye28
heart33
intestine17
kidney9
liver19
lung29
ovary49
pancreas9
placenta24
prostate5
skin37
spleen18
stomach20
testis16
uterus38
Health State
TissuesTPM*
normal18
adrenal tumor79
cervical tumor57
chondrosarcoma72
colorectal tumor8
gastrointestinal tumor16
germ cell tumor11
glioma37
leukemia63
liver tumor41
lung tumor19
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS133
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult19
embryoid body14
neonate64
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland10.9
appendix9.5
bone marrow4.5
cerebral cortex4.5
colon5.4
duodenum6.2
esophagus3.1
gallbladder4.4
heart muscle3.2
kidney10.2
liver2.9
lung10
lymph node3.4
ovary9.9
pancreas19.8
placenta5.1
prostate10.7
salivary gland9
skin9.8
small intestine6.2
spleen8.3
stomach7
testis17.6
thyroid gland4.8
urinary bladder3.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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