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> Protein (NX_Q9H0R8)
Protein (NX_Q9H0R8)
Protein
Gene SymbolGABARAPL1 to neXtProt (NX_Q9H0R8)
DescriptionGamma-aminobutyric acid receptor-associated protein-like 1
Chromosome12
Location12p13.2 (10365057 ~ 10375727) to Ensembl
Sequene Features : Isoforms 2, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 14 1
2014-09-19protein level
2 10 1
2014-05-27protein level
2 10 2
2014-02-25protein level
2 10 2
2013-12-09protein level
2 10 2
2013-11-01protein level
2 8 1
2013-09-12protein level
2 8 1
2013-08-17protein level
2 8 1
2013-07-15protein level
2 4 1
2013-06-11protein level
2 4 1
2013-02-12protein level
2 1 1
2012-12-20protein level
2 1 1
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 1 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H0R8-1
1 1 1 14035.1994
NX_Q9H0R8-2
2 1 1 16997.0282
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746969,EBI-356424 IPO5  
  .cellular response to amino acid stimulus
.positive regulation of protein import into nucleus
.negative regulation of GTPase activity
  + 3 more...
.poly(A) RNA binding
.protein transporter activity
.Ran GTPase binding
.GTPase inhibitor activity
.intracellular membrane-bounded organelle
.nuclear membrane
.membrane
  + 6 more...
2 EBI-746969,EBI-2946991 TECPR2  
  .autophagy .N/A .N/A
3 EBI-746969,EBI-2798775 ATG13  
  .positive regulation of protein targeting to mitochondrion
.activation of mitophagy in response to mitochondrial depolarization
.autophagic vacuole assembly
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.cytosol
  + 2 more...
4 EBI-746969,EBI-307133 GBAS  
  .negative regulation of ATP citrate synthase activity
.ATP biosynthetic process
.oxidative phosphorylation
.N/A .membrane
.integral component of plasma membrane
.mitochondrion
5 EBI-746969,EBI-908831 ULK1  
  .regulation of neurotrophin TRK receptor signaling pathway
.axon extension
.negative regulation of collateral sprouting
  + 15 more...
.protein complex binding
.Rab GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.extrinsic component of autophagic vacuole membrane
.extrinsic component of pre-autophagosomal structure membrane
.extrinsic component of omegasome membrane
  + 9 more...
6 EBI-746969,EBI-2947137 STBD1  
  .muscle contraction .starch binding .membrane
.integral component of plasma membrane
7 EBI-746969,EBI-987834 ATG7  
  .negative regulation of histone H4-K16 acetylation
.regulation of mitochondrion degradation
.cellular response to hyperoxia
  + 33 more...
.protein homodimerization activity
.Atg8 activating enzyme activity
.Atg12 activating enzyme activity
  + 2 more...
.axoneme
.cytosol
.cytoplasm
.pre-autophagosomal structure
8 EBI-746969,EBI-476431 PRKAR1A  
  .negative regulation of cAMP-dependent protein kinase activity
.cellular response to glucagon stimulus
.cardiac muscle cell proliferation
  + 20 more...
.protein kinase A catalytic subunit binding
.ubiquitin protein ligase binding
.cAMP binding
  + 2 more...
.ciliary base
.protein complex
.neuromuscular junction
  + 5 more...
9 EBI-746969,EBI-356720 HADHA  
  .glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 5 more...
.NAD binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
.long-chain-enoyl-CoA hydratase activity
  + 4 more...
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
.mitochondrial inner membrane
.mitochondrion
10 EBI-3464833,EBI-925028 OPRK1  
  .defense response to virus
.regulation of saliva secretion
.opioid receptor signaling pathway
  + 10 more...
.neuropeptide binding
.dynorphin receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
11 EBI-746969,EBI-726944 NEDD4  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
  + 32 more...
.proline-rich region binding
.RNA polymerase binding
.ubiquitin protein ligase activity
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apicolateral plasma membrane
  + 8 more...
12 EBI-746969,EBI-356635 HADHB  
  .glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 3 more...
.NAD binding
.poly(A) RNA binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
  + 5 more...
.extracellular exosome
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
  + 5 more...
13 EBI-3464833,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
14 EBI-3464833,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
15 EBI-746969,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
16 EBI-746969,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
17 EBI-746969,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
18 EBI-746969,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
19 EBI-746969,EBI-352869 SAFB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
20 EBI-746969,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
21 EBI-746969,EBI-1171113 CLINT1  
  .membrane organization
.clathrin coat assembly
.endocytosis
.post-Golgi vesicle-mediated transport
.clathrin binding
.lipid binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.clathrin-coated vesicle
  + 4 more...
22 EBI-3464833,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
23 EBI-746969,EBI-2514077 ATG2A  
  .nucleophagy
.cellular response to nitrogen starvation
.mitochondrion degradation
.autophagic vacuole assembly
.N/A .pre-autophagosomal structure membrane
.extrinsic component of membrane
.lipid particle
.pre-autophagosomal structure
24 EBI-746969,EBI-2514778 KBTBD6  
  .N/A .N/A .N/A
25 EBI-3464833,EBI-10192441 FAM134C  
  .N/A .N/A .integral component of membrane
26 EBI-3464833,EBI-10217765 AHNAK2  
  .N/A .N/A .costamere
.sarcolemma
.cytoplasmic vesicle membrane
  + 5 more...
27 EBI-3464833,EBI-1380680 SCYL3  
  .cell migration
.protein phosphorylation
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.lamellipodium
.Golgi apparatus
.cytoplasm
28 EBI-746969,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
29 EBI-746969,EBI-80799 NCOA7  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.nuclear hormone receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
.nucleus
.intracellular
30 EBI-746969,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
31 EBI-746969,EBI-1044009 NEK9  
  .cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
32 EBI-746969,EBI-2946919 FNIP1  
  .regulation of pro-B cell differentiation
.positive regulation of GTPase activity
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 9 more...
.guanyl-nucleotide exchange factor activity .cytoplasm
33 EBI-746969,EBI-473695 KBTBD7  
  .N/A .N/A .N/A
34 EBI-746969,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
35 EBI-746969,EBI-2946907 DYX1C1  
  .regulation of proteasomal protein catabolic process
.inner dynein arm assembly
.outer dynein arm assembly
  + 4 more...
.estrogen receptor binding .plasma membrane
.cytoplasm
.nucleus
36 EBI-3464833,EBI-3044060 ATG4A  
  .protein delipidation
.nucleophagy
.protein processing
  + 6 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
37 EBI-746969,EBI-2947053 NSMAF  
  .positive regulation of apoptotic process
.intracellular signal transduction
.endosomal transport
  + 2 more...
.sphingomyelin phosphodiesterase activator activity
.phospholipid binding
.receptor signaling protein activity
.extrinsic component of membrane
.endomembrane system
.cytoplasm
38 EBI-746969,EBI-2869338 FYCO1  
  .plus-end-directed vesicle transport along microtubule .metal ion binding .cytoplasmic vesicle
.integral component of membrane
.membrane
  + 3 more...
39 EBI-746969,EBI-747805 UBA5  
  .protein polyufmylation
.protein ufmylation
.response to endoplasmic reticulum stress
.regulation of intracellular estrogen receptor signaling pathway
.UFM1 activating enzyme activity
.metal ion binding
.ATP binding
.intracellular membrane-bounded organelle
.cytosol
.cytoplasm
.nucleus
40 EBI-746969,EBI-988094 ATG3  
  .regulation of cilium assembly
.nucleophagy
.mitochondrial fragmentation involved in apoptotic process
  + 5 more...
.enzyme binding
.ubiquitin-like protein transferase activity
.Atg12 transferase activity
  + 2 more...
.cytosol
.cytoplasmic ubiquitin ligase complex
41 EBI-746969,EBI-2947180 TBC1D2B  
  .N/A .GTPase activator activity .N/A
42 EBI-746969,EBI-1057545 RABGAP1  
  .positive regulation of GTPase activity
.cell cycle
.Rab GTPase binding
.tubulin binding
.GTPase activator activity
.DNA binding
.microtubule associated complex
.cytosol
.centrosome
43 EBI-746969,EBI-712014 ATG4B  
  .protein delipidation
.positive regulation of protein catabolic process
.nucleophagy
  + 9 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.endopeptidase activity
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland121
bladder167
blood139
bone69
bone marrow20
brain457
cervix247
connective tissue67
ear62
embryonic tissue103
esophagus148
eye148
heart457
intestine56
kidney218
larynx42
liver126
lung155
lymph node111
mammary gland105
mouth90
muscle131
nerve450
ovary68
pancreas74
parathyroid242
pituitary gland60
placenta455
prostate94
salivary gland98
skin75
spleen56
stomach135
testis96
thymus188
thyroid150
trachea115
umbilical cord145
uterus81
vascular77
Health State
TissuesTPM*
normal259
bladder carcinoma113
breast (mammary gland) tumor139
cervical tumor231
chondrosarcoma96
esophageal tumor173
gastrointestinal tumor101
germ cell tumor383
glioma102
head and neck tumor89
kidney tumor333
leukemia84
liver tumor114
lung tumor29
non-neoplasia403
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS102
prostate cancer48
retinoblastoma129
skin tumor55
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult229
embryoid body114
blastocyst146
neonate96
fetus163
infant42
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue95.4
adrenal gland87.2
appendix33
bone marrow91.3
cerebral cortex206.3
colon32.4
duodenum33.2
esophagus29.8
gallbladder72.7
heart muscle155.6
kidney176
liver112.2
lung66.1
lymph node14.1
ovary45.8
pancreas42.9
placenta177.5
prostate58.5
salivary gland73.7
skin13.5
small intestine31.8
spleen26.2
stomach45.4
testis30.8
thyroid gland50.2
urinary bladder46.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607420, gene) Gaba-a receptor-associated protein-like protein 1; GABARAPL1OMIM


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