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> Protein (NX_Q9H165)
Protein (NX_Q9H165)
Protein
Gene SymbolBCL11A to neXtProt (NX_Q9H165)
DescriptionB-cell lymphoma/leukemia 11A
Chromosome2
Location2p16.1 (60678302 ~ 60780702) to Ensembl
Sequene Features : Isoforms 6, Variants 154, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of dendrite development
.regulation of dendrite development
.positive regulation of collateral sprouting
  + 10 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 154 10
2014-09-19protein level
6 101 10
2014-05-27protein level
6 100 14
2014-02-25protein level
6 100 14
2013-12-09protein level
6 91 14
2013-11-01protein level
6 87 13
2013-09-12protein level
6 87 13
2013-08-17protein level
6 87 13
2013-07-15protein level
6 60 9
2013-06-11protein level
6 60 9
2013-02-12protein level
6 23 42
2012-12-20protein level
6 25 42
2012-10-30protein level
6 26 42
2012-10-07protein level
6 26 9
2012-08-24protein level
6 8 9
2012-07-28protein level
6 8 9
2012-06-08protein level
6 7 9
2012-05-07protein level
6 7 9
2012-04-10protein level
6 7 9
2012-01-13protein level
6 7 9
2011-12-20protein level
6 7 9
2011-11-11protein level
6 7 9
2011-08-23protein level
6 7 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H165-1
0 34 5 91139.1312
NX_Q9H165-2
0 35 1 83807.668
NX_Q9H165-3
1 9 0 26848.2114
NX_Q9H165-4
1 35 1 86364.9748
NX_Q9H165-5
2 11 0 30231.8086
NX_Q9H165-6
0 33 5 87498.3021
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10183342,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
2 EBI-10183342,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
3 EBI-10183342,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
4 EBI-10183342,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood57
brain40
connective tissue6
embryonic tissue32
esophagus49
eye9
heart11
intestine12
kidney4
larynx42
lung50
lymph90
lymph node356
mammary gland6
mouth30
ovary29
pancreas28
parathyroid97
placenta3
prostate5
skin23
testis2
thymus37
uterus4
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor10
colorectal tumor17
esophageal tumor57
germ cell tumor34
glioma9
head and neck tumor22
kidney tumor14
leukemia63
lung tumor9
lymphoma96
ovarian tumor39
retinoblastoma21
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
embryoid body14
blastocyst32
fetus109
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland2.7
appendix12.1
bone marrow13.9
cerebral cortex17.3
colon6.1
duodenum9.6
esophagus22.3
gallbladder6.5
heart muscle5.5
lung2.7
lymph node42.1
pancreas4.5
placenta2
prostate4.9
salivary gland12
skin42.2
small intestine9.6
spleen17.8
stomach3.3
testis1.8
thyroid gland2.2
urinary bladder5.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%142335, phenotype) Fetal hemoglobin quantitative trait locus 5; HBFQTL5OMIM
2(*606557, gene) B-cell cll/lymphoma 11a; BCL11AOMIM
3B-cell Lymphocytic leukemiaCGP


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