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> Protein (NX_Q9H1K1)
Protein (NX_Q9H1K1)
Protein
Gene SymbolISCU to neXtProt (NX_Q9H1K1)
DescriptionIron-sulfur cluster assembly enzyme ISCU, mitochondrial
Chromosome12
Location12q23.3 (108956358 ~ 108963160) to Ensembl
Sequene Features : Isoforms 2, Variants 23, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein maturation by iron-sulfur cluster transfer
.[2Fe-2S] cluster assembly
.small molecule metabolic process
  + 3 more...
.4 iron, 4 sulfur cluster binding
.2 iron, 2 sulfur cluster binding
.iron-sulfur transferase activity
  + 3 more...
.cytosol
.mitochondrial matrix
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 23 7
2014-09-19protein level
2 19 7
2014-05-27protein level
2 19 7
2014-02-25protein level
2 19 7
2013-12-09protein level
2 15 7
2013-11-01protein level
2 15 1
2013-09-12protein level
2 15 1
2013-08-17protein level
2 15 1
2013-07-15protein level
2 11 1
2013-06-11protein level
2 11 1
2013-02-12protein level
2 6 2
2012-12-20protein level
2 5 2
2012-10-30protein level
2 7 2
2012-10-07protein level
2 7 2
2012-08-24protein level
2 6 2
2012-07-28protein level
2 6 2
2012-06-08protein level
2 7 2
2012-05-07protein level
2 7 2
2012-04-10protein level
2 7 2
2012-01-13protein level
2 12 2
2011-12-20protein level
2 12 2
2011-11-11protein level
2 12 2
2011-08-23protein level
2 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H1K1-1
3 6 0 17987.5808
NX_Q9H1K1-2
1 6 0 15252.8774
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047335,EBI-748210 HPRT1  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.dendrite morphogenesis
  + 23 more...
.guanine phosphoribosyltransferase activity
.protein homodimerization activity
.hypoxanthine phosphoribosyltransferase activity
  + 2 more...
.extracellular exosome
.cytosol
.cytoplasm
2 EBI-1047335,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
3 EBI-1047335,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
4 EBI-1047335,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-1047335,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
6 EBI-1047335,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-1047335,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
8 EBI-1047335,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
9 EBI-1047335,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
10 EBI-1047335,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
11 EBI-1047335,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
bladder66
blood40
bone181
bone marrow82
brain110
cervix41
connective tissue93
ear372
embryonic tissue37
eye124
heart44
intestine60
kidney71
larynx383
liver29
lung74
lymph112
lymph node89
mammary gland52
mouth15
muscle37
nerve64
ovary39
pancreas93
parathyroid242
pharynx24
pituitary gland181
placenta45
prostate36
skin109
spleen74
stomach20
testis91
thymus100
thyroid42
tonsil117
trachea19
umbilical cord145
uterus68
vascular19
Health State
TissuesTPM*
normal76
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor53
chondrosarcoma253
colorectal tumor35
gastrointestinal tumor8
germ cell tumor3
glioma74
head and neck tumor97
kidney tumor58
leukemia21
liver tumor31
lung tumor19
lymphoma124
non-neoplasia93
ovarian tumor13
pancreatic tumor152
primitive neuroectodermal tumor of the CNS94
prostate cancer38
retinoblastoma21
skin tumor135
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult75
blastocyst65
neonate64
fetus77
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue108.7
adrenal gland278
appendix93
bone marrow74
cerebral cortex97.5
colon100.7
duodenum80.7
esophagus80.5
gallbladder118.6
heart muscle325.6
kidney210.8
liver52.4
lung101.5
lymph node135.5
ovary147.3
pancreas39.5
placenta103.5
prostate111.3
salivary gland90.7
skin61.3
small intestine84.2
spleen109.4
stomach79.6
testis95.3
thyroid gland180.3
urinary bladder140.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#255125, phenotype) Myopathy with lactic acidosis, hereditary; HMLOMIM
2(*611911, gene) Iron-sulfur cluster scaffold, e. coli, homolog of; ISCUOMIM


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