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> Protein (NX_Q9H1Y0)
Protein (NX_Q9H1Y0)
Protein
Gene SymbolATG5 to neXtProt (NX_Q9H1Y0)
DescriptionAutophagy protein 5
Chromosome6
Location6q21 (106632351 ~ 106773666) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of histone H4-K16 acetylation
.regulation of reactive oxygen species metabolic process
.regulation of cilium assembly
  + 23 more...
.N/A .ER-mitochondrion membrane contact site
.Atg12-Atg5-Atg16 complex
.pre-autophagosomal structure membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 2
2014-09-19protein level
2 15 2
2014-05-27protein level
2 15 2
2014-02-25protein level
2 15 2
2013-12-09protein level
2 14 2
2013-11-01protein level
2 14 2
2013-09-12protein level
2 14 1
2013-08-17protein level
2 14 1
2013-07-15protein level
2 7 1
2013-06-11protein level
2 7 1
2013-02-12protein level
2 5 2
2012-12-20protein level
2 5 2
2012-10-30protein level
2 6 2
2012-10-07protein level
2 6 1
2012-08-24protein level
2 4 1
2012-07-28protein level
2 4 1
2012-06-08protein level
2 6 1
2012-05-07protein level
2 6 1
2012-04-10protein level
2 6 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H1Y0-1
5 10 0 32426.2207
NX_Q9H1Y0-2
1 10 0 22916.4216
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047414,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-1047414,EBI-2946676 TECPR1  
  .autophagy
.autophagic vacuole fusion
.phosphatidylinositol-3-phosphate binding .cytoplasmic vesicle
.integral component of membrane
.lysosomal membrane
.autophagic vacuole membrane
3 EBI-1047414,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
4 EBI-1047414,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood24
bone111
bone marrow20
brain25
cervix41
connective tissue60
ear124
embryonic tissue84
esophagus49
eye14
heart55
intestine68
kidney61
liver9
lung62
lymph45
lymph node111
mammary gland59
mouth15
muscle9
ovary29
pancreas42
pharynx24
placenta81
prostate73
skin14
spleen37
stomach52
testis29
thymus25
trachea19
uterus56
Health State
TissuesTPM*
normal47
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma84
colorectal tumor79
esophageal tumor57
gastrointestinal tumor42
germ cell tumor56
glioma9
head and neck tumor7
kidney tumor14
leukemia52
liver tumor20
lung tumor38
lymphoma69
non-neoplasia31
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS55
prostate cancer57
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor47
uterine tumor77
Developmental Stage
TissuesTPM*
adult53
embryoid body71
blastocyst97
fetus52
infant42
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.1
adrenal gland22.3
appendix15.5
bone marrow14.4
cerebral cortex11.9
colon22.3
duodenum18.9
esophagus24.8
gallbladder21.3
heart muscle10.3
kidney15.4
liver12.2
lung13.3
lymph node21.2
ovary16.8
pancreas6.1
placenta18.6
prostate16.7
salivary gland11.3
skin10.8
small intestine19.2
spleen11.5
stomach15.6
testis14.9
thyroid gland30.1
urinary bladder31.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604261, gene) Autophagy 5, s. cerevisiae, homolog of; ATG5OMIM


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