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> Protein (NX_Q9H204)
Protein (NX_Q9H204)
Protein
Gene SymbolMED28 to neXtProt (NX_Q9H204)
DescriptionMediator of RNA polymerase II transcription subunit 28
Chromosome4
Location4p15.32 (17616254 ~ 17635728) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 1
2014-09-19protein level
1 15 1
2014-05-27protein level
1 15 1
2014-02-25protein level
1 15 1
2013-12-09protein level
1 11 1
2013-11-01protein level
1 11 0
2013-09-12protein level
1 11 0
2013-08-17protein level
1 11 0
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H204-1
6 0 0 19507.9723
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-514199,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
2 EBI-514199,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-514199,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
4 EBI-514199,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
5 EBI-514199,EBI-1014472 NF2  
  .regulation of neural precursor cell proliferation
.regulation of protein localization to nucleus
.lens fiber cell differentiation
  + 22 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.ruffle membrane
  + 13 more...
6 EBI-514199,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
7 EBI-514199,EBI-394687 MED22  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
.cytoplasm
8 EBI-514199,EBI-310506 MAGI3  
  .nucleotide phosphorylation
.positive regulation of JUN kinase activity
.intracellular signal transduction
  + 2 more...
.ATP binding
.guanylate kinase activity
.membrane
.tight junction
.plasma membrane
.nucleus
9 EBI-514199,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
10 EBI-514199,EBI-912440 PRMT6  
  .negative regulation of transcription, DNA-templated
.histone H4-R3 methylation
.histone H3-R2 methylation
  + 6 more...
.histone methyltransferase activity (H2A-R3 specific)
.histone methyltransferase activity (H3-R2 specific)
.histone methyltransferase activity (H4-R3 specific)
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
11 EBI-514199,EBI-394656 MED29  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .mediator complex
.nucleoplasm
12 EBI-514199,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
bone13
brain13
connective tissue20
embryonic tissue108
eye23
heart78
intestine43
kidney14
liver53
lung38
lymph node44
mammary gland26
muscle18
nerve64
ovary19
pancreas65
parathyroid48
placenta49
prostate5
skin14
stomach10
testis25
thymus25
thyroid21
tonsil117
umbilical cord726
uterus56
vascular38
Health State
TissuesTPM*
normal33
adrenal tumor79
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor62
gastrointestinal tumor8
germ cell tumor45
glioma37
head and neck tumor7
leukemia21
liver tumor83
lung tumor29
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS62
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor71
uterine tumor33
Developmental Stage
TissuesTPM*
adult32
embryoid body71
blastocyst146
neonate321
fetus43
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18
adrenal gland12
appendix20.8
bone marrow17.4
cerebral cortex11.7
colon17.7
duodenum13.1
esophagus12.4
gallbladder10.5
heart muscle8.8
kidney16.2
liver8
lung11.5
lymph node20.8
ovary19.3
pancreas4.6
placenta19.8
prostate17.4
salivary gland11.7
skin9.4
small intestine12.1
spleen23.8
stomach22.1
testis15.4
thyroid gland12.1
urinary bladder14.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610311, gene) Mediator complex subunit 28; MED28OMIM


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