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> Protein (NX_Q9H222)
Protein (NX_Q9H222)
Protein
Gene SymbolABCG5 to neXtProt (NX_Q9H222)
DescriptionATP-binding cassette sub-family G member 5
Chromosome2
Location2p21 (44039611 ~ 44066004) to Ensembl
Sequene Features : Isoforms 2, Variants 103, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.negative regulation of intestinal cholesterol absorption
.small molecule metabolic process
  + 9 more...
.protein heterodimerization activity
.cholesterol transporter activity
.ATPase activity
.ATP binding
.receptor complex
.ATP-binding cassette (ABC) transporter complex
.apical plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 103 2
2014-09-19protein level
2 94 2
2014-05-27protein level
1 94 2
2014-02-25protein level
1 93 2
2013-12-09protein level
1 72 2
2013-11-01protein level
1 67 2
2013-09-12protein level
1 67 3
2013-08-17protein level
1 67 3
2013-07-15protein level
1 48 3
2013-06-11protein level
1 48 3
2013-02-12protein level
1 31 3
2012-12-20protein level
1 32 3
2012-10-30protein level
1 36 3
2012-10-07protein level
1 36 3
2012-08-24protein level
1 34 3
2012-07-28protein level
1 34 3
2012-06-08protein level
1 34 3
2012-05-07protein level
1 34 3
2012-04-10protein level
1 34 3
2012-01-13protein level
1 22 3
2011-12-20protein level
1 22 3
2011-11-11protein level
1 22 3
2011-08-23protein level
1 22 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H222-1
20 9 0 72456.6722
NX_Q9H222-2
1 9 0 28460.9376
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1761423,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1761423,EBI-3908684 ABCG8  
  .transmembrane transport
.negative regulation of intestinal cholesterol absorption
.small molecule metabolic process
  + 9 more...
.protein heterodimerization activity
.cholesterol transporter activity
.ATPase activity
.ATP binding
.receptor complex
.ATP-binding cassette (ABC) transporter complex
.apical plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
eye4
liver48
lung2
stomach10
Health State
TissuesTPM*
normal4
liver tumor62
Developmental Stage
TissuesTPM*
adult3
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
duodenum57.7
gallbladder1.6
liver28
small intestine54.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#210250, phenotype) SitosterolemiaOMIM
2(*605459, gene) Atp-binding cassette, subfamily g, member 5; ABCG5OMIM


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