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> Protein (NX_Q9H257)
Protein (NX_Q9H257)
Protein
Gene SymbolCARD9 to neXtProt (NX_Q9H257)
DescriptionCaspase recruitment domain-containing protein 9
Chromosome9
Location9q34.3 (139256355 ~ 139268133) to Ensembl
Sequene Features : Isoforms 3, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 75 3
2014-09-19protein level
3 62 3
2014-05-27protein level
3 62 3
2014-02-25protein level
3 60 1
2013-12-09protein level
3 46 1
2013-11-01protein level
3 45 1
2013-09-12protein level
3 45 1
2013-08-17protein level
3 45 1
2013-07-15protein level
3 29 1
2013-06-11protein level
3 29 1
2013-02-12protein level
3 19 2
2012-12-20protein level
3 18 2
2012-10-30protein level
3 20 2
2012-10-07protein level
3 20 1
2012-08-24protein level
3 17 1
2012-07-28protein level
3 17 1
2012-06-08protein level
3 17 1
2012-05-07protein level
3 16 1
2012-04-10protein level
3 16 1
2012-01-13protein level
3 4 1
2011-12-20protein level
3 4 1
2011-11-11protein level
3 4 1
2011-08-23protein level
3 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H257-1
2 22 1 62201.7373
NX_Q9H257-2
1 22 1 56631.0442
NX_Q9H257-3
1 16 1 42925.9771
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751319,EBI-487024 ABLIM1  
  .positive regulation of transcription from RNA polymerase II promoter
.cilium assembly
.lamellipodium assembly
  + 4 more...
.zinc ion binding
.actin binding
.lamellipodium
.actin cytoskeleton
.cytoplasm
.stress fiber
2 EBI-751319,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
3 EBI-751319,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-751319,EBI-958922 BCL10  
  .positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
5 EBI-751319,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
6 EBI-751319,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-751319,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
8 EBI-751319,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
9 EBI-751319,EBI-348489 PBX2  
  .positive regulation of transcription from RNA polymerase II promoter
.embryonic limb morphogenesis
.proximal/distal pattern formation
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.transcription factor complex
.nucleus
10 EBI-751319,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
11 EBI-751319,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
12 EBI-751319,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
13 EBI-751319,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
14 EBI-751319,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
15 EBI-751319,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
16 EBI-751319,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
17 EBI-751319,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
18 EBI-751319,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
19 EBI-751319,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
20 EBI-751319,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
21 EBI-751319,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
22 EBI-751319,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
23 EBI-751319,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
24 EBI-751319,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
25 EBI-751319,EBI-946029 C1orf94  
  .N/A .N/A .N/A
26 EBI-751319,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
27 EBI-751319,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-751319,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
29 EBI-751319,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
30 EBI-751319,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
31 EBI-751319,EBI-7265024 ZCCHC7  
  .N/A .poly(A) RNA binding
.zinc ion binding
.cytoplasm
.nucleolus
.nucleus
32 EBI-751319,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
33 EBI-751319,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
34 EBI-751319,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
35 EBI-751319,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
36 EBI-751319,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
37 EBI-751319,EBI-726510 LENG1  
  .N/A .N/A .N/A
38 EBI-751319,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
39 EBI-751319,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
40 EBI-751319,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
41 EBI-751319,EBI-742638 TSNAX  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.cell differentiation
.protein transport
  + 3 more...
.metal ion binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 4 more...
.perinuclear region of cytoplasm
.cytosol
.Golgi apparatus
  + 2 more...
42 EBI-751319,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
43 EBI-751319,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
44 EBI-751319,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
45 EBI-751319,EBI-741626 FAM124B  
  .N/A .N/A .N/A
46 EBI-751319,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
47 EBI-751319,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
48 EBI-751319,EBI-749800 DUSP13  
  .spermatogenesis
.meiotic nuclear division
.protein dephosphorylation
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.N/A
49 EBI-751319,EBI-742802 FAM50B  
  .N/A .N/A .nucleus
50 EBI-751319,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
51 EBI-751319,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
52 EBI-751319,EBI-1043104 USP15  
  .regulation of proteasomal protein catabolic process
.pathway-restricted SMAD protein phosphorylation
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitinated histone binding
.SMAD binding
.identical protein binding
  + 3 more...
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood49
bone marrow123
brain10
connective tissue20
esophagus99
eye19
intestine4
kidney9
liver14
lung5
muscle9
pancreas4
placenta21
spleen112
uterus12
Health State
TissuesTPM*
normal12
colorectal tumor8
esophageal tumor115
leukemia10
liver tumor20
non-neoplasia31
retinoblastoma64
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult9
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.3
adrenal gland1.6
appendix6.2
bone marrow12.6
cerebral cortex1.1
colon1.4
duodenum1.9
esophagus1.2
gallbladder2.4
lung3.3
lymph node2.6
placenta1.9
prostate1.1
salivary gland1.6
skin3.7
small intestine2.7
spleen9.1
stomach1.9
urinary bladder2.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#212050, phenotype) Candidiasis, familial, 2; CANDF2OMIM
2(*607212, gene) Caspase recruitment domain-containing protein 9; CARD9OMIM


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