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> Protein (NX_Q9H2G9)
Protein (NX_Q9H2G9)
Protein
Gene SymbolBLZF1 to neXtProt (NX_Q9H2G9)
DescriptionGolgin-45
Chromosome1
Location1q24.2 (169337208 ~ 169365778) to Ensembl
Sequene Features : Isoforms 2, Variants 65, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 65 4
2014-09-19protein level
2 58 4
2014-05-27protein level
2 58 4
2014-02-25protein level
2 57 4
2013-12-09protein level
2 49 4
2013-11-01protein level
2 49 4
2013-09-12protein level
2 49 4
2013-08-17protein level
2 49 4
2013-07-15protein level
2 29 4
2013-06-11protein level
2 29 4
2013-02-12protein level
2 19 7
2012-12-20protein level
2 19 7
2012-10-30protein level
2 19 7
2012-10-07protein level
2 19 5
2012-08-24protein level
2 18 5
2012-07-28protein level
2 18 5
2012-06-08protein level
2 19 5
2012-05-07protein level
2 15 5
2012-04-10protein level
2 15 5
2012-01-13protein level
2 9 5
2011-12-20protein level
2 9 5
2011-11-11protein level
2 9 3
2011-08-23protein level
2 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H2G9-1
14 8 0 44882.1954
NX_Q9H2G9-2
1 8 0 19350.275
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2548012,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
2 EBI-2548012,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
3 EBI-2548012,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
4 EBI-2548012,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
5 EBI-2548012,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
6 EBI-2548012,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
7 EBI-2548012,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
8 EBI-2548012,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
9 EBI-2548012,EBI-752037 RAB2A  
  .Rab protein signal transduction
.metabolic process
.Golgi organization
  + 3 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.melanosome
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 4 more...
10 EBI-2548012,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
11 EBI-2548012,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
12 EBI-2548012,EBI-3048577 RAB39A  
  .phagosome-lysosome fusion
.phagosome acidification
.Rab protein signal transduction
  + 2 more...
.GTP binding
.GTPase activity
.phagocytic vesicle
.phagocytic vesicle membrane
.plasma membrane
.Golgi apparatus
13 EBI-2548012,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
14 EBI-2548012,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
15 EBI-2548012,EBI-720304 ZNF410  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
16 EBI-2548012,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
17 EBI-2548012,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
18 EBI-2548012,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
19 EBI-2548012,EBI-5542466 RAB2B  
  .positive regulation of exocytosis
.Rab protein signal transduction
.vesicle-mediated transport
  + 2 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.endoplasmic reticulum membrane
.Golgi membrane
20 EBI-2548012,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
21 EBI-2548012,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
22 EBI-2548012,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
23 EBI-2548012,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
24 EBI-2548012,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
25 EBI-2548012,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
26 EBI-2548012,EBI-6285694 RHOJ  
  .retina vasculature morphogenesis in camera-type eye
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.cytosol
27 EBI-2548012,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
28 EBI-2548012,EBI-3258000 TBC1D7  
  .negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
29 EBI-2548012,EBI-747601 TRAPPC2L  
  .ER to Golgi vesicle-mediated transport .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.cytoplasm
30 EBI-2548012,EBI-10281601 OAZ3  
  .negative regulation of polyamine transmembrane transport
.positive regulation of protein catabolic process
.small molecule metabolic process
  + 6 more...
.putrescine transmembrane transporter activity
.ornithine decarboxylase inhibitor activity
.blood microparticle
.sperm flagellum
.cytosol
.nucleus
31 EBI-2548012,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
blood49
bone41
bone marrow41
brain25
cervix164
connective tissue40
embryonic tissue9
eye43
heart11
intestine8
kidney66
larynx127
liver53
lung8
lymph node55
mammary gland39
mouth15
muscle18
ovary19
pancreas79
parathyroid48
pharynx24
placenta109
prostate21
salivary gland49
skin42
stomach10
testis73
thymus12
thyroid21
uterus30
vascular174
Health State
TissuesTPM*
normal42
adrenal tumor158
breast (mammary gland) tumor10
chondrosarcoma72
colorectal tumor8
gastrointestinal tumor25
germ cell tumor26
glioma27
head and neck tumor37
kidney tumor43
leukemia52
liver tumor20
non-neoplasia31
ovarian tumor13
pancreatic tumor142
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult46
blastocyst16
neonate96
fetus21
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland12.1
appendix12.3
bone marrow11.8
cerebral cortex8.8
colon13.6
duodenum9.6
esophagus29.4
gallbladder15.6
heart muscle11.6
kidney12.3
liver6.6
lung10.1
lymph node9.8
ovary12.1
pancreas4.1
placenta13.6
prostate12.3
salivary gland8.3
skin12.6
small intestine10.4
spleen9.1
stomach11.1
testis27.5
thyroid gland16
urinary bladder13.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608692, gene) Basic leucine zipper nuclear factor 1; BLZF1OMIM


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