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> Protein (NX_Q9H2V7)
Protein (NX_Q9H2V7)
Protein
Gene SymbolSPNS1 to neXtProt (NX_Q9H2V7)
DescriptionProtein spinster homolog 1
Chromosome16
Location16p11.2 (28985542 ~ 28995869) to Ensembl
Sequene Features : Isoforms 5, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.locomotion
.sphingosine-1-phosphate signaling pathway
.sphingolipid transporter activity .vesicle
.integral component of membrane
.lysosomal membrane
.mitochondrial inner membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 66 2
2014-09-19protein level
5 48 2
2014-05-27protein level
5 48 2
2014-02-25protein level
5 47 2
2013-12-09protein level
5 38 2
2013-11-01protein level
5 37 2
2013-09-12protein level
5 37 2
2013-08-17protein level
5 37 2
2013-07-15protein level
5 23 1
2013-06-11protein level
5 23 1
2013-02-12protein level
5 12 8
2012-12-20protein level
5 12 8
2012-10-30protein level
5 10 8
2012-10-07protein level
5 10 2
2012-08-24protein level
5 9 2
2012-07-28protein level
5 9 2
2012-06-08protein level
5 9 2
2012-05-07protein level
5 6 2
2012-04-10protein level
5 6 2
2012-01-13protein level
5 1 2
2011-12-20protein level
5 7 2
2011-11-11protein level
5 7 2
2011-08-23protein level
5 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H2V7-1
0 20 0 56593.5677
NX_Q9H2V7-2
0 19 0 51299.8992
NX_Q9H2V7-3
1 18 0 48981.7625
NX_Q9H2V7-4
0 16 0 49107.9224
NX_Q9H2V7-5
1 9 0 24578.4011
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1386527,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
blood245
bone83
bone marrow102
brain38
cervix206
connective tissue20
embryonic tissue70
eye114
heart22
intestine73
kidney33
larynx127
liver14
lung38
lymph node33
mammary gland33
mouth15
muscle9
nerve128
ovary68
pancreas51
placenta77
prostate26
skin170
spleen37
stomach83
testis41
thymus50
thyroid21
trachea19
uterus43
Health State
TissuesTPM*
normal50
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma96
colorectal tumor62
gastrointestinal tumor135
germ cell tumor56
glioma83
head and neck tumor37
kidney tumor29
leukemia137
liver tumor20
lung tumor58
lymphoma69
non-neoplasia20
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS188
prostate cancer38
retinoblastoma150
skin tumor263
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult69
embryoid body28
blastocyst48
neonate32
fetus39
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14
adrenal gland10.3
appendix15.1
bone marrow17.3
cerebral cortex11
colon12.2
duodenum15.2
esophagus10.3
gallbladder16.1
heart muscle8.1
kidney14.1
liver8.4
lung19.9
lymph node15.3
ovary9.7
pancreas7.7
placenta17.8
prostate11.5
salivary gland10.7
skin17.6
small intestine13.8
spleen20
stomach13.2
testis12.8
thyroid gland11.4
urinary bladder15.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusLow
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeLow
nasopharynxLow
pancreasLow
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
seminal vesicleMedium
skin 1Low
skin 2Low
small intestineMedium
spleenLow
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612583, gene) Spinster, drosophila, homolog of, 1; SPNS1OMIM


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