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> Protein (NX_Q9H3D4)
Protein (NX_Q9H3D4)
Protein
Gene SymbolTP63 to neXtProt (NX_Q9H3D4)
DescriptionTumor protein 63
Chromosome3
Location3q28 (189349205 ~ 189615068) to Ensembl
Sequene Features : Isoforms 12, Variants 198, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.negative regulation of cellular senescence
.negative regulation of mesoderm development
  + 54 more...
.WW domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 10 more...
.dendrite
.cytosol
.rough endoplasmic reticulum
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
12 198 1
2014-09-19protein level
12 147 1
2014-05-27protein level
12 143 1
2014-02-25protein level
12 142 1
2013-12-09protein level
12 128 1
2013-11-01protein level
12 115 1
2013-09-12protein level
12 115 1
2013-08-17protein level
12 115 1
2013-07-15protein level
12 83 1
2013-06-11protein level
12 83 1
2013-02-12protein level
12 60 6
2012-12-20protein level
12 60 6
2012-10-30protein level
12 62 6
2012-10-07protein level
12 62 1
2012-08-24protein level
12 61 1
2012-07-28protein level
12 61 1
2012-06-08protein level
12 75 1
2012-05-07protein level
12 53 1
2012-04-10protein level
12 53 1
2012-01-13protein level
12 53 1
2011-12-20protein level
12 53 1
2011-11-11protein level
12 53 1
2011-08-23protein level
12 53 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H3D4-1
0 27 0 76736.1442
NX_Q9H3D4-10
1 21 0 56713.0812
NX_Q9H3D4-11
0 27 0 76267.8649
NX_Q9H3D4-12
0 23 0 65245.8963
NX_Q9H3D4-2
0 23 0 65714.1756
NX_Q9H3D4-3
0 22 0 62393.1329
NX_Q9H3D4-4
0 18 0 51371.1643
NX_Q9H3D4-5
0 20 0 55652.087
NX_Q9H3D4-6
0 16 0 44630.1184
NX_Q9H3D4-7
0 22 0 57581.9171
NX_Q9H3D4-8
0 18 0 46559.9485
NX_Q9H3D4-9
1 25 0 67735.0498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2337775,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-2337775,EBI-400434 FUS  
  .regulation of nucleic acid-templated transcription
.gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 4 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-2337775,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
4 EBI-2337775,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
5 EBI-2400586,EBI-604615 CABLES1  
  .regulation of cell cycle
.cell division
.blood coagulation
  + 2 more...
.N/A .cytosol
.nucleus
6 EBI-2337775,EBI-716291 NIPSNAP3A  
  .N/A .N/A .cytosol
.nucleus
7 EBI-6481107,EBI-8298169 SATB2  
  .cellular response to organic substance
.palate development
.cartilage development
  + 9 more...
.sequence-specific DNA binding
.chromatin binding
.nuclear matrix
.cytoplasm
.transcription factor complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder167
connective tissue6
embryonic tissue23
esophagus99
eye14
heart134
intestine4
larynx85
lung23
lymph22
mouth801
muscle37
pharynx122
placenta14
prostate42
skin66
testis11
thymus50
thyroid21
trachea57
Health State
TissuesTPM*
normal16
colorectal tumor8
esophageal tumor115
head and neck tumor448
lymphoma13
non-neoplasia31
skin tumor55
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult40
embryoid body42
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus60.4
lung2
lymph node1.1
placenta11.6
prostate15.6
salivary gland10
skin115.5
testis4.4
urinary bladder29.1
Tissues
TissuesExpression level
breastMedium
bronchusHigh
cervix, uterineHigh
epididymisMedium
esophagusHigh
nasopharynxHigh
oral mucosaHigh
placentaMedium
prostateMedium
seminal vesicleMedium
skin 1High
skin 2High
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#103285, phenotype) Adult syndromeOMIM
2(#106260, phenotype) Ankyloblepharon-ectodermal defects-cleft lip/palateOMIM
3(#129400, phenotype) Rapp-hodgkin syndrome; RHSOMIM
4(*603273, gene) Tumor protein p63; TP63OMIM
5(#603543, phenotype) Limb-mammary syndrome; LMSOMIM
6(#604292, phenotype) Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndromeOMIM
7(#605289, phenotype) Split-hand/foot malformation 4; SHFM4OMIM


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