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> Protein (NX_Q9H3R5)
Protein (NX_Q9H3R5)
Protein
Gene SymbolCENPH to neXtProt (NX_Q9H3R5)
DescriptionCentromere protein H
Chromosome5
Location5q13.2 (68485375 ~ 68506184) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.kinetochore organization
.kinetochore assembly
.CENP-A containing nucleosome assembly
  + 3 more...
.kinetochore binding .cytosol
.nucleoplasm
.nucleus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 4
2014-09-19protein level
1 17 4
2014-05-27protein level
1 17 4
2014-02-25protein level
1 17 4
2013-12-09protein level
1 14 4
2013-11-01protein level
1 14 3
2013-09-12protein level
1 14 3
2013-08-17protein level
1 14 3
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 5 1
2012-10-07protein level
1 5 1
2012-08-24protein level
1 5 1
2012-07-28protein level
1 5 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H3R5-1
13 0 0 28462.7684
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1003700,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-1003700,EBI-2547776 MTAP  
  .small molecule metabolic process
.purine-containing compound salvage
.cellular nitrogen compound metabolic process
  + 5 more...
.S-methyl-5-thioadenosine phosphorylase activity
.purine-nucleoside phosphorylase activity
.phosphorylase activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
3 EBI-1003700,EBI-6871750 CENPK  
  .positive regulation of transcription from RNA polymerase II promoter
.CENP-A containing nucleosome assembly
.small GTPase mediated signal transduction
  + 2 more...
.N/A .cytosol
.nucleoplasm
.condensed chromosome kinetochore
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone13
bone marrow82
brain7
cervix20
embryonic tissue112
eye14
intestine21
kidney4
lymph112
lymph node11
mammary gland6
pancreas9
placenta17
prostate10
salivary gland148
skin4
testis2
Health State
TissuesTPM*
normal11
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor30
glioma27
leukemia42
lymphoma69
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma64
Developmental Stage
TissuesTPM*
adult4
embryoid body42
blastocyst195
fetus7
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland2.5
appendix8.3
bone marrow21.9
cerebral cortex2.2
colon7.4
duodenum6.6
esophagus6.6
gallbladder2.2
heart muscle3.1
kidney1.6
liver2.2
lung3
lymph node17.6
ovary3.9
placenta5.8
prostate3.1
salivary gland1.4
skin8.2
small intestine5.6
spleen4.9
stomach4.5
testis29.2
thyroid gland2.4
urinary bladder6.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
cerebellumHigh
cerebral cortexLow
colonLow
duodenumMedium
endometrium 2Low
esophagusLow
gallbladderLow
heart muscleMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
lymph nodeLow
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
salivary glandLow
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
stomach 1Medium
stomach 2Low
testisMedium
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605607, gene) Centromeric protein h; CENPHOMIM


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