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> Protein (NX_Q9H3S7)
Protein (NX_Q9H3S7)
Protein
Gene SymbolPTPN23 to neXtProt (NX_Q9H3S7)
DescriptionTyrosine-protein phosphatase non-receptor type 23
Chromosome3
Location3p21.31 (47422501 ~ 47454931) to Ensembl
Sequene Features : Isoforms 1, Variants 155, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 155 9
2014-09-19protein level
1 124 9
2014-05-27protein level
1 124 9
2014-02-25protein level
1 124 9
2013-12-09protein level
1 80 9
2013-11-01protein level
1 75 8
2013-09-12protein level
1 75 8
2013-08-17protein level
1 75 8
2013-07-15protein level
1 47 4
2013-06-11protein level
1 47 4
2013-02-12protein level
1 36 4
2012-12-20protein level
1 34 4
2012-10-30protein level
1 44 4
2012-10-07protein level
1 44 4
2012-08-24protein level
1 42 4
2012-07-28protein level
1 42 4
2012-06-08protein level
1 40 4
2012-05-07protein level
1 40 4
2012-04-10protein level
1 40 4
2012-01-13protein level
1 19 4
2011-12-20protein level
1 19 4
2011-11-11protein level
1 19 4
2011-08-23protein level
1 19 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H3S7-1
67 0 0 178860.4478
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724478,EBI-352915 PDCD6  
  .apoptotic signaling pathway
.negative regulation of protein kinase B signaling
.response to calcium ion
  + 12 more...
.binding, bridging
.calcium-dependent protein binding
.protein dimerization activity
  + 4 more...
.endoplasmic reticulum exit site
.extracellular exosome
.nuclear membrane
  + 6 more...
2 EBI-724478,EBI-740418 GRAP2  
  .T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
3 EBI-724478,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-724478,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
5 EBI-724478,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-724478,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
7 EBI-724478,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-724478,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
9 EBI-724478,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
10 EBI-724478,EBI-749627 CHMP4B  
  .negative regulation of autophagic vacuole assembly
.positive regulation of viral release from host cell
.regulation of mitotic spindle assembly
  + 18 more...
.protein homodimerization activity
.identical protein binding
.extracellular exosome
.late endosome membrane
.midbody
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood24
bone13
bone marrow41
brain39
cervix20
connective tissue26
embryonic tissue37
eye52
heart11
intestine73
kidney42
larynx127
liver43
lung41
lymph90
lymph node122
mammary gland52
mouth15
nerve128
ovary118
pancreas70
placenta35
prostate21
salivary gland49
skin99
stomach10
testis16
thymus25
thyroid21
tonsil58
trachea19
uterus38
vascular19
Health State
TissuesTPM*
normal36
bladder carcinoma113
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma60
colorectal tumor79
gastrointestinal tumor16
germ cell tumor53
glioma111
head and neck tumor37
kidney tumor43
leukemia31
liver tumor93
lung tumor68
lymphoma69
non-neoplasia20
ovarian tumor131
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor159
soft tissue/muscle tissue tumor55
uterine tumor55
Developmental Stage
TissuesTPM*
adult44
embryoid body57
blastocyst65
fetus32
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland12.2
appendix12.3
bone marrow11.3
cerebral cortex13.1
colon8.6
duodenum12.1
esophagus9.6
gallbladder9.6
heart muscle6.9
kidney10.9
liver4.2
lung12.3
lymph node9.9
ovary14
pancreas6.3
placenta12
prostate11.8
salivary gland10.9
skin16.1
small intestine10.6
spleen16.5
stomach13.2
testis13.5
thyroid gland13.7
urinary bladder9.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606584, gene) Protein-tyrosine phosphatase, nonreceptor-type, 23; PTPN23OMIM


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