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> Protein (NX_Q9H3U1)
Protein (NX_Q9H3U1)
Protein
Gene SymbolUNC45A to neXtProt (NX_Q9H3U1)
DescriptionProtein unc-45 homolog A
Chromosome15
Location15q26.1 (91473410 ~ 91497323) to Ensembl
Sequene Features : Isoforms 3, Variants 101, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chaperone-mediated protein folding
.cell differentiation
.muscle organ development
.N/A .perinuclear region of cytoplasm
.Golgi apparatus
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 101 10
2014-09-19protein level
3 82 10
2014-05-27protein level
3 82 10
2014-02-25protein level
3 80 10
2013-12-09protein level
3 59 10
2013-11-01protein level
3 57 6
2013-09-12protein level
3 57 6
2013-08-17protein level
3 57 6
2013-07-15protein level
3 45 4
2013-06-11protein level
3 45 4
2013-02-12protein level
3 29 7
2012-12-20protein level
3 31 7
2012-10-30protein level
3 32 7
2012-10-07protein level
3 32 5
2012-08-24protein level
3 30 5
2012-07-28protein level
3 31 5
2012-06-08protein level
3 36 5
2012-05-07protein level
3 32 5
2012-04-10protein level
3 32 5
2012-01-13protein level
3 15 5
2011-12-20protein level
3 15 5
2011-11-11protein level
3 15 5
2011-08-23protein level
3 15 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H3U1-1
1 46 0 103011.1909
NX_Q9H3U1-2
1 46 0 101610.4901
NX_Q9H3U1-3
0 12 0 24672.4419
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1048763,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
2 EBI-1048763,EBI-2341554 MARCH10  
  .protein ubiquitination .ligase activity
.zinc ion binding
.N/A
3 EBI-1048763,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites125
bladder66
blood98
bone97
bone marrow102
brain149
cervix41
connective tissue114
embryonic tissue108
esophagus49
eye95
heart55
intestine77
kidney123
larynx85
liver43
lung244
lymph67
lymph node55
mammary gland85
mouth544
muscle37
nerve64
ovary226
pancreas74
parathyroid48
pituitary gland181
placenta134
prostate84
skin132
spleen206
stomach10
testis255
thymus514
thyroid107
trachea289
umbilical cord2252
uterus86
vascular77
Health State
TissuesTPM*
normal126
adrenal tumor79
breast (mammary gland) tumor118
cervical tumor57
chondrosarcoma325
colorectal tumor53
gastrointestinal tumor84
germ cell tumor227
glioma93
head and neck tumor283
kidney tumor72
leukemia169
liver tumor41
lung tumor126
lymphoma96
non-neoplasia93
ovarian tumor144
pancreatic tumor133
primitive neuroectodermal tumor of the CNS118
prostate cancer67
retinoblastoma43
skin tumor135
soft tissue/muscle tissue tumor47
uterine tumor33
Developmental Stage
TissuesTPM*
adult97
embryoid body171
blastocyst130
neonate96
fetus159
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.4
adrenal gland25.5
appendix23.1
bone marrow19.5
cerebral cortex14.8
colon24.3
duodenum22.1
esophagus31.8
gallbladder26
heart muscle14.7
kidney28
liver9.9
lung24.4
lymph node24.9
ovary32.4
pancreas13.9
placenta25.2
prostate37.1
salivary gland27.4
skin41.8
small intestine19.4
spleen24.6
stomach22.4
testis24.4
thyroid gland21.9
urinary bladder29
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
liverHigh
lungLow
lymph nodeMedium
nasopharynxMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611219, gene) Unc45, c. elegans, homolog of, a; UNC45AOMIM


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