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> Protein (NX_Q9H469)
Protein (NX_Q9H469)
Protein
Gene SymbolFBXL15 to neXtProt (NX_Q9H469)
DescriptionF-box/LRR-repeat protein 15
Chromosome10
Location10q24.32 (104178946 ~ 104182893) to Ensembl
Sequene Features : Isoforms 1, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.positive regulation of BMP signaling pathway
.bone mineralization
  + 3 more...
.N/A .SCF ubiquitin ligase complex
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 14 1
2014-09-19protein level
1 9 1
2014-05-27protein level
1 9 1
2014-02-25protein level
1 9 1
2013-12-09protein level
1 5 1
2013-11-01protein level
1 5 1
2013-09-12protein level
1 5 0
2013-08-17protein level
1 5 0
2013-07-15protein level
1 2 0
2013-06-11protein level
1 2 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 4 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H469-1
15 0 0 32977.3445
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6144096,EBI-396727 SMURF2  
  .positive regulation of trophoblast cell migration
.positive regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 11 more...
.ubiquitin protein ligase activity
.SMAD binding
.identical protein binding
  + 2 more...
.membrane raft
.plasma membrane
.cytosol
  + 4 more...
2 EBI-6144096,EBI-976466 SMURF1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of dendrite extension
.activation of mitophagy in response to mitochondrial depolarization
  + 18 more...
.R-SMAD binding
.I-SMAD binding
.ubiquitin protein ligase activity
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bone83
brain37
cervix41
connective tissue20
embryonic tissue42
eye28
heart33
intestine25
kidney18
liver4
lung38
lymph90
mammary gland39
nerve64
ovary49
pancreas51
pituitary gland121
placenta14
prostate42
salivary gland49
skin14
testis18
tonsil235
uterus30
Health State
TissuesTPM*
normal29
breast (mammary gland) tumor32
chondrosarcoma96
colorectal tumor35
gastrointestinal tumor8
germ cell tumor15
glioma37
head and neck tumor7
kidney tumor14
liver tumor10
lung tumor58
lymphoma55
non-neoplasia20
ovarian tumor13
primitive neuroectodermal tumor of the CNS118
prostate cancer67
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body42
blastocyst48
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland3.7
appendix1.5
bone marrow1.9
cerebral cortex5.6
colon6.7
duodenum4.7
kidney6.6
liver2
lung3.2
lymph node1.1
pancreas1.5
prostate4.1
salivary gland2.5
skin1.7
small intestine3.6
spleen5.5
stomach6.8
testis2.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*610287, gene) F-box and leucine-rich repeat protein 15; FBXL15OMIM


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