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> Protein (NX_Q9H4B4)
Protein (NX_Q9H4B4)
Protein
Gene SymbolPLK3 to neXtProt (NX_Q9H4B4)
DescriptionSerine/threonine-protein kinase PLK3
Chromosome1
Location1p34.1 (45265897 ~ 45271662) to Ensembl
Sequene Features : Isoforms 1, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
.positive regulation of intracellular protein transport
.Golgi disassembly
  + 17 more...
.ATP binding
.protein serine/threonine kinase activity
.p53 binding
.neuronal cell body
.dendrite
.centrosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 73 0
2014-09-19protein level
1 60 0
2014-05-27protein level
1 60 0
2014-02-25protein level
1 60 0
2013-12-09protein level
1 47 0
2013-11-01protein level
1 46 0
2013-09-12protein level
1 46 0
2013-08-17protein level
1 46 0
2013-07-15protein level
1 32 0
2013-06-11protein level
1 32 0
2013-02-12protein level
1 24 2
2012-12-20protein level
1 25 2
2012-10-30protein level
1 25 2
2012-10-07protein level
1 25 2
2012-08-24protein level
1 23 2
2012-07-28protein level
1 23 2
2012-06-08protein level
1 34 2
2012-05-07protein level
1 32 2
2012-04-10protein level
1 32 2
2012-01-13protein level
1 28 2
2011-12-20protein level
1 28 2
2011-11-11protein level
1 24 1
2011-08-23protein level
1 24 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H4B4-1
29 0 1 71584.0131
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751877,EBI-977302 PRNP  
  .regulation of potassium ion transmembrane transport
.cellular response to copper ion
.negative regulation of calcineurin-NFAT signaling cascade
  + 17 more...
.identical protein binding
.tubulin binding
.microtubule binding
.copper ion binding
.extracellular exosome
.membrane raft
.anchored component of membrane
  + 7 more...
2 EBI-751877,EBI-624770 POU2F1  
  .lens induction in camera-type eye
.negative regulation of transcription, DNA-templated
.olfactory placode formation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.intracellular membrane-bounded organelle
.transcription factor complex
.nucleoplasm
.nucleus
3 EBI-751877,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood8
bone41
bone marrow20
brain10
connective tissue13
embryonic tissue23
eye19
intestine34
kidney18
lung38
lymph45
lymph node55
muscle65
ovary88
pancreas37
pharynx24
placenta45
skin61
stomach20
testis2
thymus25
thyroid42
uterus4
Health State
TissuesTPM*
normal18
bladder carcinoma56
chondrosarcoma48
colorectal tumor62
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor22
leukemia21
lung tumor19
lymphoma69
non-neoplasia31
ovarian tumor118
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult34
embryoid body42
blastocyst16
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland11.4
appendix23.8
bone marrow62.4
cerebral cortex6.4
colon10
duodenum7.4
esophagus26.8
gallbladder32.3
heart muscle4.7
kidney4.9
liver12.4
lung24.4
lymph node19.7
ovary6.1
pancreas7.4
placenta11.7
prostate6.9
salivary gland4.5
skin13.4
small intestine8.7
spleen10.6
stomach9
testis4.1
thyroid gland7.5
urinary bladder13.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602913, gene) Polo-like kinase 3; PLK3OMIM


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