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> Protein (NX_Q9H4P4)
Protein (NX_Q9H4P4)
Protein
Gene SymbolRNF41 to neXtProt (NX_Q9H4P4)
DescriptionE3 ubiquitin-protein ligase NRDP1
Chromosome12
Location12q13.2 (56598285 ~ 56615717) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.regulation of establishment of cell polarity
  + 12 more...
.ubiquitin protein ligase activity
.protein tag
.Ral GTPase binding
  + 3 more...
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 1
2014-09-19protein level
2 27 1
2014-05-27protein level
2 27 1
2014-02-25protein level
2 27 1
2013-12-09protein level
2 23 1
2013-11-01protein level
2 22 0
2013-09-12protein level
2 22 0
2013-08-17protein level
2 22 0
2013-07-15protein level
2 11 0
2013-06-11protein level
2 11 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 4 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H4P4-1
2 11 0 35881.6106
NX_Q9H4P4-2
0 11 0 27946.8879
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2130266,EBI-476655 RFC4  
  .error-free translesion synthesis
.DNA damage response, detection of DNA damage
.error-prone translesion synthesis
  + 12 more...
.ATP binding
.DNA binding
.cytoplasm
.DNA replication factor C complex
.nucleoplasm
.nucleus
2 EBI-2130266,EBI-10248982 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
3 EBI-2130266,EBI-10258659 ISCA2  
  .iron-sulfur cluster assembly .iron-sulfur cluster binding
.metal ion binding
.structural molecule activity
.mitochondrion
4 EBI-2130266,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
5 EBI-2130266,EBI-742074 TTC1  
  .protein folding .unfolded protein binding .peroxisomal membrane
.cytoplasm
6 EBI-2130266,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
7 EBI-2130266,EBI-2126733 HOMER2  
  .regulation of store-operated calcium entry
.chemical homeostasis within a tissue
.behavioral response to cocaine
  + 3 more...
.G-protein coupled glutamate receptor binding .neuronal postsynaptic density
.postsynaptic membrane
.apical part of cell
  + 8 more...
8 EBI-2130266,EBI-6425205 ASB6  
  .intracellular signal transduction
.protein ubiquitination
.N/A .cytoplasm
9 EBI-2130266,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites50
bladder33
blood81
bone69
bone marrow143
brain67
cervix103
connective tissue53
embryonic tissue28
eye57
heart44
intestine25
kidney80
liver14
lung62
lymph22
lymph node122
mammary gland6
mouth15
muscle47
nerve64
ovary59
pancreas60
parathyroid48
pharynx49
pituitary gland60
placenta17
prostate73
salivary gland49
skin47
spleen56
testis48
thymus25
thyroid42
trachea19
umbilical cord72
uterus90
vascular58
Health State
TissuesTPM*
normal57
adrenal tumor158
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma96
colorectal tumor26
gastrointestinal tumor25
germ cell tumor45
glioma83
head and neck tumor29
kidney tumor87
leukemia52
liver tumor31
lung tumor68
lymphoma83
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer67
skin tumor15
soft tissue/muscle tissue tumor55
uterine tumor166
Developmental Stage
TissuesTPM*
adult42
embryoid body14
blastocyst65
neonate64
fetus70
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30
adrenal gland24.2
appendix21.1
bone marrow14.2
cerebral cortex31.5
colon17.8
duodenum11.7
esophagus21.7
gallbladder25.9
heart muscle26.4
kidney19.1
liver9.6
lung22.8
lymph node25
ovary22.9
pancreas10.2
placenta20.1
prostate32.1
salivary gland10.4
skin10
small intestine12.4
spleen21.3
stomach15.9
testis19
thyroid gland30.6
urinary bladder25.8
Tissues
TissuesExpression level
adrenal glandLow
bronchusLow
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeLow
heart muscleLow
hippocampusHigh
kidneyLow
lateral ventricleHigh
lungLow
nasopharynxMedium
ovaryHigh
pancreasMedium
placentaMedium
salivary glandLow
skeletal muscleMedium
small intestineLow
spleenLow
stomach 1Medium
stomach 2Low
testisHigh
thyroid glandMedium
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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