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> Protein (NX_Q9H5I5)
Protein (NX_Q9H5I5)
Protein
Gene SymbolPIEZO2 to neXtProt (NX_Q9H5I5)
DescriptionPiezo-type mechanosensitive ion channel component 2
Chromosome18
Location18p11.21 (10666480 ~ 11148587) to Ensembl
Sequene Features : Isoforms 4, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.detection of mechanical stimulus involved in sensory perception
.regulation of membrane potential
.response to mechanical stimulus
.cation transport
.mechanically-gated ion channel activity
.cation channel activity
.integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 76 3
2014-09-19protein level
4 152 3
2014-05-27protein level
4 151 3
2014-02-25protein level
4 150 3
2013-12-09protein level
4 113 3
2013-11-01protein level
4 105 3
2013-09-12protein level
4 105 3
2013-08-17protein level
4 105 3
2013-07-15protein level
4 66 3
2013-06-11protein level
4 66 3
2013-02-12protein level
4 33 9
2012-12-20protein level
4 50 9
2012-10-30protein level
4 58 9
2012-10-07protein level
4 58 3
2012-08-24transcript level
4 50 3
2012-07-28transcript level
4 50 3
2012-06-08transcript level
4 4 3
2012-05-07transcript level
4 4 3
2012-04-10transcript level
5 4 3
2012-01-13transcript level
5 4 3
2011-12-20transcript level
5 7 3
2011-11-11transcript level
5 7 3
2011-08-23transcript level
5 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H5I5-1
0 124 0 317857.4849
NX_Q9H5I5-2
1 122 0 310872.5783
NX_Q9H5I5-3
1 29 0 80742.7087
NX_Q9H5I5-4
3 123 0 320682.0839
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain14
connective tissue33
embryonic tissue14
eye28
heart33
intestine8
kidney4
liver4
lung47
prostate15
skin4
spleen18
testis13
uterus4
vascular58
Health State
TissuesTPM*
normal29
chondrosarcoma12
germ cell tumor18
kidney tumor14
liver tumor10
non-neoplasia10
uterine tumor11
Developmental Stage
TissuesTPM*
adult8
blastocyst32
fetus70
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
adrenal gland1.1
appendix2.4
cerebral cortex5.2
colon1.8
duodenum1.3
esophagus8
gallbladder9.9
kidney2
liver4.1
lung9
lymph node2.1
ovary1
prostate3.7
skin1.8
small intestine1.4
spleen3.6
stomach1.8
testis2.7
thyroid gland2.5
urinary bladder8.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%108145, phenotype) Arthrogryposis, distal, type 5; DA5OMIM
2(%114300, phenotype) Arthrogryposis, distal, type 3; DA3OMIM
3(%248700, phenotype) Marden-walker syndromeOMIM
4(*613629, gene) Family with sequence similarity 38, member b; FAM38BOMIM


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