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> Protein (NX_Q9H668)
Protein (NX_Q9H668)
Protein
Gene SymbolOBFC1 to neXtProt (NX_Q9H668)
DescriptionCST complex subunit STN1
Chromosome10
Location10q24.33 (105642300 ~ 105677963) to Ensembl
Sequene Features : Isoforms 1, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of DNA replication
.telomere maintenance via telomere lengthening
.telomere maintenance
.single-stranded telomeric DNA binding
.single-stranded DNA binding
.Stn1-Ten1 complex
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 44 2
2014-09-19protein level
1 37 2
2014-05-27protein level
1 37 2
2014-02-25protein level
1 37 2
2013-12-09protein level
1 27 2
2013-11-01protein level
1 25 2
2013-09-12protein level
1 25 2
2013-08-17protein level
1 25 2
2013-07-15protein level
1 18 0
2013-06-11protein level
1 18 0
2013-02-12protein level
1 11 0
2012-12-20protein level
1 10 0
2012-10-30protein level
1 14 0
2012-10-07protein level
1 14 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 10 0
2012-05-07protein level
1 10 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 6 0
2011-12-20protein level
1 6 0
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H668-1
19 0 0 42092.4197
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746930,EBI-2562802 CTC1  
  .replicative senescence
.hematopoietic stem cell proliferation
.bone marrow development
  + 9 more...
.single-stranded DNA binding .Stn1-Ten1 complex
.nucleus
.nuclear chromosome, telomeric region
2 EBI-746930,EBI-747813 LDLRAP1  
  .positive regulation of cholesterol metabolic process
.receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
.regulation of establishment of protein localization to plasma membrane
  + 9 more...
.low-density lipoprotein particle receptor binding
.clathrin adaptor activity
.AP-2 adaptor complex binding
  + 6 more...
.recycling endosome
.axon
.basal plasma membrane
  + 4 more...
3 EBI-746930,EBI-2562799 TEN1  
  .N/A .single-stranded DNA binding .Stn1-Ten1 complex
.nucleus
.nuclear chromosome, telomeric region
4 EBI-746930,EBI-717666 ACD  
  .protein localization to chromosome, telomeric region
.positive regulation of single-stranded telomeric DNA binding
.positive regulation of telomerase activity
  + 10 more...
.DNA polymerase binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder33
blood40
bone97
bone marrow41
brain23
connective tissue53
embryonic tissue14
esophagus49
eye43
heart78
intestine43
kidney23
liver19
lung80
lymph22
lymph node11
mammary gland6
mouth15
muscle18
ovary19
pancreas18
parathyroid145
pharynx49
placenta60
prostate26
salivary gland49
skin52
spleen74
stomach52
testis29
thymus12
thyroid21
uterus30
Health State
TissuesTPM*
normal38
adrenal tumor79
chondrosarcoma84
colorectal tumor53
esophageal tumor57
gastrointestinal tumor16
germ cell tumor30
glioma9
head and neck tumor29
leukemia52
liver tumor31
lung tumor48
lymphoma55
non-neoplasia72
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult41
fetus26
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.6
adrenal gland24.6
appendix14.9
bone marrow9.4
cerebral cortex7
colon15.1
duodenum10.3
esophagus35.6
gallbladder20.1
heart muscle27.6
kidney16.7
liver7
lung23.5
lymph node17.1
ovary21.4
pancreas10.3
placenta15.5
prostate9.9
salivary gland9.8
skin11.6
small intestine10.4
spleen15.1
stomach21.5
testis27.5
thyroid gland19.2
urinary bladder27.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613128, gene) Oligonucleotide/oligosaccharide-binding fold-containing protein 1;OMIM


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