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> Protein (NX_Q9H6Q3)
Protein (NX_Q9H6Q3)
Protein
Gene SymbolSLA2 to neXtProt (NX_Q9H6Q3)
DescriptionSrc-like-adapter 2
Chromosome20
Location20q11.23 (35240721 ~ 35274619) to Ensembl
Sequene Features : Isoforms 4, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of B cell activation
.antigen receptor-mediated signaling pathway
.negative regulation of calcium-mediated signaling
  + 6 more...
.protein N-terminus binding
.SH3/SH2 adaptor activity
.cytoplasmic membrane-bounded vesicle
.endosome membrane
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 39 2
2014-09-19protein level
4 27 2
2014-05-27protein level
4 27 2
2014-02-25protein level
4 26 2
2013-12-09protein level
4 11 2
2013-11-01protein level
4 10 2
2013-09-12protein level
4 10 2
2013-08-17protein level
4 10 2
2013-07-15protein level
4 7 1
2013-06-11protein level
4 7 1
2013-02-12protein level
4 7 2
2012-12-20protein level
4 7 2
2012-10-30protein level
4 9 2
2012-10-07protein level
4 9 1
2012-08-24protein level
4 7 1
2012-07-28protein level
4 7 1
2012-06-08protein level
4 8 1
2012-05-07protein level
4 8 1
2012-04-10protein level
4 8 1
2012-01-13protein level
4 5 1
2011-12-20protein level
4 5 1
2011-11-11protein level
4 5 1
2011-08-23protein level
4 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H6Q3-1
0 12 1 28567.5452
NX_Q9H6Q3-2
0 10 1 23088.5977
NX_Q9H6Q3-3
0 11 1 25846.1301
NX_Q9H6Q3-4
0 9 1 20367.1826
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1222854,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-1222854,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-1222854,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-1222854,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood98
bone marrow82
connective tissue6
eye4
heart11
intestine17
liver4
lung2
lymph node33
mammary gland13
placenta7
prostate15
skin4
spleen74
thymus75
Health State
TissuesTPM*
normal7
breast (mammary gland) tumor21
colorectal tumor17
germ cell tumor11
leukemia52
liver tumor10
lymphoma27
non-neoplasia10
prostate cancer28
retinoblastoma21
skin tumor7
Developmental Stage
TissuesTPM*
adult5
neonate32
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix5.5
bone marrow7.1
colon1.5
duodenum2.3
gallbladder2.7
lung2.9
lymph node9.9
salivary gland1.2
small intestine2.8
spleen5.6
stomach2.7
urinary bladder2.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*606577, gene) Src-like adaptor 2; SLA2OMIM


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