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> Protein (NX_Q9H6U6)
Protein (NX_Q9H6U6)
Protein
Gene SymbolBCAS3 to neXtProt (NX_Q9H6U6)
DescriptionBreast carcinoma-amplified sequence 3
Chromosome17
Location17q23.2 (58754814 ~ 59470199) to Ensembl
Sequene Features : Isoforms 6, Variants 108, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.regulation of establishment of cell polarity
.activation of GTPase activity
  + 16 more...
.beta-tubulin binding
.histone binding
.nuclear hormone receptor binding
  + 4 more...
.cell periphery
.intermediate filament cytoskeleton
.transcriptionally active chromatin
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 108 5
2014-09-19protein level
6 73 5
2014-05-27protein level
6 72 5
2014-02-25protein level
6 72 5
2013-12-09protein level
6 54 5
2013-11-01protein level
6 54 5
2013-09-12protein level
6 54 5
2013-08-17protein level
6 54 5
2013-07-15protein level
6 34 5
2013-06-11protein level
6 34 5
2013-02-12protein level
6 13 23
2012-12-20protein level
6 14 23
2012-10-30protein level
6 17 23
2012-10-07protein level
6 17 4
2012-08-24protein level
6 14 4
2012-07-28protein level
6 14 4
2012-06-08protein level
6 10 4
2012-05-07protein level
6 10 4
2012-04-10protein level
6 10 4
2012-01-13protein level
6 10 4
2011-12-20protein level
6 10 4
2011-11-11protein level
6 10 4
2011-08-23protein level
6 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H6U6-1
0 42 0 101171.8333
NX_Q9H6U6-2
0 41 0 99617.101
NX_Q9H6U6-3
0 41 0 102041.3565
NX_Q9H6U6-6
1 30 0 74192.5256
NX_Q9H6U6-7
1 39 0 101451.2197
NX_Q9H6U6-8
0 42 0 103596.0888
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6083685,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
2 EBI-6083685,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-10307911,EBI-946080 C16orf70  
  .N/A .N/A .N/A
4 EBI-6083685,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder33
bone13
bone marrow61
brain141
cervix20
connective tissue73
embryonic tissue28
eye52
heart11
intestine21
kidney28
liver19
lung53
lymph22
lymph node11
mammary gland79
mouth332
muscle75
nerve64
ovary29
pancreas37
parathyroid97
pharynx49
placenta49
prostate26
skin147
spleen112
stomach20
testis174
thymus50
trachea135
umbilical cord72
uterus60
Health State
TissuesTPM*
normal76
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma48
gastrointestinal tumor59
germ cell tumor102
glioma18
head and neck tumor164
leukemia10
liver tumor20
lung tumor29
lymphoma41
non-neoplasia72
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
retinoblastoma21
skin tumor199
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult48
embryoid body71
neonate32
fetus93
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.2
adrenal gland9.5
appendix5.7
bone marrow7.3
cerebral cortex16.2
colon7.6
duodenum6.4
esophagus20.8
gallbladder19.4
heart muscle12
kidney11.3
liver9.2
lung13.7
lymph node10.1
ovary11.2
pancreas6.3
placenta11.7
prostate10.2
salivary gland8.7
skin14.4
small intestine5.8
spleen8.8
stomach7.5
testis25.2
thyroid gland21.3
urinary bladder27.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607470, gene) Breast carcinoma amplified sequence 3; BCAS3OMIM


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