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> Protein (NX_Q9H706)
Protein (NX_Q9H706)
Protein
Gene SymbolGAREM to neXtProt (NX_Q9H706)
DescriptionGRB2-associated and regulator of MAPK protein
Chromosome18
Location18q12.1 (29704840 ~ 30050447) to Ensembl
Sequene Features : Isoforms 3, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to epidermal growth factor stimulus
.positive regulation of ERK1 and ERK2 cascade
.positive regulation of cell division
  + 2 more...
.proline-rich region binding .plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 34 2
2014-09-19protein level
3 87 2
2014-05-27protein level
3 87 2
2014-02-25protein level
3 85 2
2013-12-09protein level
3 66 2
2013-11-01protein level
3 62 2
2013-09-12protein level
3 62 2
2013-08-17protein level
3 62 2
2013-07-15protein level
3 44 2
2013-06-11protein level
3 44 2
2013-02-12protein level
3 22 12
2012-12-20protein level
3 20 9
2012-10-30protein level
3 26 9
2012-10-07protein level
3 26 3
2012-08-24protein level
3 17 3
2012-07-28protein level
3 17 3
2012-06-08protein level
3 17 3
2012-05-07protein level
3 17 3
2012-04-10protein level
3 17 3
2012-01-13protein level
3 14 3
2011-12-20protein level
3 14 3
2011-11-11protein level
3 14 3
2011-08-23protein level
3 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H706-1
1 42 2 97124.5331
NX_Q9H706-2
1 39 1 89950.6193
NX_Q9H706-3
1 42 2 97037.5013
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3440103,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder33
blood8
bone13
brain23
connective tissue20
embryonic tissue9
esophagus49
eye33
heart44
intestine12
kidney66
liver14
lung44
mammary gland33
mouth15
muscle28
nerve64
pancreas4
pituitary gland60
placenta3
prostate26
skin14
stomach31
testis32
uterus4
vascular38
Health State
TissuesTPM*
normal28
bladder carcinoma284
breast (mammary gland) tumor21
colorectal tumor17
esophageal tumor57
gastrointestinal tumor59
germ cell tumor3
glioma9
head and neck tumor7
kidney tumor43
liver tumor10
lung tumor87
non-neoplasia20
prostate cancer28
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult20
fetus43
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland6.9
appendix2.6
bone marrow1.1
cerebral cortex8.5
colon6.5
duodenum4.7
esophagus8.5
gallbladder3.4
heart muscle6.4
kidney12
liver5.6
lung4.2
ovary2.9
pancreas18.1
placenta4
prostate2.7
salivary gland7.1
skin6.6
small intestine5.1
spleen2.2
stomach11
testis5.1
thyroid gland2.4
urinary bladder9.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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