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> Protein (NX_Q9H788)
Protein (NX_Q9H788)
Protein
Gene SymbolSH2D4A to neXtProt (NX_Q9H788)
DescriptionSH2 domain-containing protein 4A
Chromosome8
Location8p21.3 (19171128 ~ 19253729) to Ensembl
Sequene Features : Isoforms 2, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of phosphatase activity .phosphatase binding .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 64 4
2014-09-19protein level
2 54 4
2014-05-27protein level
2 54 4
2014-02-25protein level
2 53 4
2013-12-09protein level
2 37 4
2013-11-01protein level
2 36 4
2013-09-12protein level
2 36 4
2013-08-17protein level
2 36 4
2013-07-15protein level
2 29 4
2013-06-11protein level
2 29 4
2013-02-12protein level
2 18 12
2012-12-20protein level
2 18 12
2012-10-30protein level
2 23 12
2012-10-07protein level
2 23 6
2012-08-24protein level
2 23 6
2012-07-28protein level
2 23 6
2012-06-08protein level
2 31 6
2012-05-07protein level
2 28 6
2012-04-10protein level
2 28 6
2012-01-13protein level
1 19 6
2011-12-20protein level
1 19 6
2011-11-11protein level
1 19 3
2011-08-23protein level
1 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H788-1
2 16 0 52694.0375
NX_Q9H788-2
1 16 0 46948.8956
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747035,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-747035,EBI-1215506 CASK  
  .negative regulation of cellular response to growth factor stimulus
.positive regulation of calcium ion import
.calcium ion import
  + 9 more...
.ATP binding
.protein serine/threonine kinase activity
.guanylate kinase activity
.ciliary membrane
.presynaptic membrane
.nuclear matrix
  + 10 more...
3 EBI-747035,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
4 EBI-10308083,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
5 EBI-747035,EBI-624237 TACC1  
  .cell division
.regulation of microtubule-based process
.interkinetic nuclear migration
  + 5 more...
.N/A .intermediate filament cytoskeleton
.microtubule cytoskeleton
.microtubule organizing center
  + 2 more...
6 EBI-747035,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
7 EBI-747035,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
8 EBI-10308083,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
9 EBI-747035,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
10 EBI-747035,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
11 EBI-747035,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
12 EBI-747035,EBI-750369 HCLS1  
  .positive regulation of actin cytoskeleton reorganization
.negative regulation of leukocyte apoptotic process
.cellular response to cytokine stimulus
  + 17 more...
.protein kinase binding
.RNA polymerase II transcription factor binding
.membrane
.mitochondrion
.cytoplasm
  + 2 more...
13 EBI-747035,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
14 EBI-10308083,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
15 EBI-747035,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
16 EBI-747035,EBI-739552 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
17 EBI-747035,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
18 EBI-747035,EBI-352350 PPP1CB  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 13 more...
.myosin-light-chain-phosphatase activity
.metal ion binding
.protein kinase binding
  + 2 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 7 more...
19 EBI-10308083,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
20 EBI-10308083,EBI-711925 ZBTB16  
  .positive regulation of cartilage development
.cartilage development
.positive regulation of NK T cell differentiation
  + 22 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.transcriptional repressor complex
.nuclear speck
.PML body
  + 5 more...
21 EBI-747035,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
22 EBI-747035,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
23 EBI-747035,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
24 EBI-10308083,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
25 EBI-747035,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
26 EBI-747035,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
27 EBI-747035,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
28 EBI-747035,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
29 EBI-747035,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
30 EBI-747035,EBI-2477305 SKAP1  
  .T cell receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of signal transduction
.SH2 domain binding
.protein phosphatase binding
.protein kinase binding
  + 2 more...
.cell-cell junction
.plasma membrane
.cytoplasm
.nucleus
31 EBI-747035,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
32 EBI-747035,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
33 EBI-10308083,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
34 EBI-747035,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
35 EBI-10308083,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
36 EBI-747035,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
37 EBI-747035,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
38 EBI-747035,EBI-697911 SH3GL1  
  .central nervous system development
.signal transduction
.endocytosis
.identical protein binding
.lipid binding
.cell projection
.early endosome membrane
.cell junction
  + 2 more...
39 EBI-747035,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
40 EBI-10308083,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
41 EBI-747035,EBI-751783 DBNL  
  .ruffle assembly
.podosome assembly
.neuron projection morphogenesis
  + 8 more...
.actin filament binding
.enzyme activator activity
.actin binding
.extracellular exosome
.clathrin-coated vesicle membrane
.dendrite
  + 10 more...
42 EBI-747035,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
bladder33
bone27
bone marrow20
brain5
cervix61
connective tissue53
embryonic tissue14
esophagus49
eye9
heart33
intestine25
kidney33
liver68
lung56
mammary gland19
mouth30
muscle47
ovary29
pancreas4
placenta14
prostate21
salivary gland49
skin4
spleen18
stomach73
testis2
trachea19
uterus30
vascular58
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor67
germ cell tumor7
head and neck tumor14
kidney tumor29
liver tumor83
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer9
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult25
neonate32
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.2
adrenal gland5.8
appendix4.3
colon13.2
duodenum10
esophagus16.2
gallbladder12.1
heart muscle1.7
kidney12.9
liver17.4
lung15.1
ovary35.2
pancreas4.2
placenta17.2
prostate7.3
salivary gland17
skin4.7
small intestine11.1
spleen3.5
stomach27.3
testis3.3
thyroid gland17.1
urinary bladder23
Tissues
TissuesExpression level
appendixMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverHigh
lungLow
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
small intestineLow
soft tissue 1Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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