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> Protein (NX_Q9H7H0)
Protein (NX_Q9H7H0)
Protein
Gene SymbolMETTL17 to neXtProt (NX_Q9H7H0)
DescriptionMethyltransferase-like protein 17, mitochondrial
Chromosome14
Location14q11.2 (21457929 ~ 21465189) to Ensembl
Sequene Features : Isoforms 3, Variants 81, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 81 0
2014-09-19protein level
3 59 0
2014-05-27protein level
3 59 0
2014-02-25protein level
3 59 0
2013-12-09protein level
3 44 0
2013-11-01protein level
3 40 0
2013-09-12protein level
3 40 0
2013-08-17protein level
3 40 0
2013-07-15protein level
3 33 0
2013-06-11protein level
3 33 0
2013-02-12protein level
3 22 0
2012-12-20protein level
3 22 0
2012-10-30protein level
3 28 0
2012-10-07protein level
3 28 0
2012-08-24protein level
3 27 0
2012-07-28protein level
3 27 0
2012-06-08protein level
3 29 0
2012-05-07protein level
3 23 0
2012-04-10protein level
3 23 0
2012-01-13protein level
3 14 0
2011-12-20protein level
3 14 0
2011-11-11protein level
3 14 0
2011-08-23transcript level
3 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H7H0-1
1 20 0 50701.163
NX_Q9H7H0-2
1 20 0 49568.5741
NX_Q9H7H0-3
3 20 0 53017.0726
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749353,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
2 EBI-749353,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
3 EBI-749353,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
4 EBI-749353,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
5 EBI-749353,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
6 EBI-749353,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-749353,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
8 EBI-749353,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
9 EBI-749353,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
10 EBI-749353,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
11 EBI-749353,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites200
bladder66
blood73
bone97
bone marrow61
brain55
cervix206
connective tissue26
embryonic tissue93
esophagus198
eye114
heart100
intestine47
kidney9
larynx85
liver53
lung95
lymph45
lymph node111
mammary gland39
mouth15
muscle47
nerve193
ovary49
pancreas28
parathyroid48
pharynx24
pituitary gland121
placenta84
prostate21
skin75
spleen37
stomach94
testis45
thymus250
thyroid42
tonsil235
trachea19
umbilical cord72
uterus112
Health State
TissuesTPM*
normal74
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma108
colorectal tumor26
esophageal tumor173
gastrointestinal tumor143
germ cell tumor34
glioma37
head and neck tumor29
kidney tumor14
leukemia137
liver tumor41
lung tumor77
lymphoma110
non-neoplasia31
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS196
prostate cancer19
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor99
Developmental Stage
TissuesTPM*
adult70
embryoid body14
blastocyst130
neonate32
fetus68
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.3
adrenal gland57.7
appendix46.3
bone marrow42.9
cerebral cortex22.6
colon41.4
duodenum78.3
esophagus37.9
gallbladder41.1
heart muscle37.7
kidney35.5
liver19.2
lung43.7
lymph node71
ovary51.5
pancreas21.6
placenta38.6
prostate38.2
salivary gland45.8
skin73
small intestine60.3
spleen55.7
stomach44.4
testis39.8
thyroid gland40.5
urinary bladder45.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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