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> Protein (NX_Q9H8P0)
Protein (NX_Q9H8P0)
Protein
Gene SymbolSRD5A3 to neXtProt (NX_Q9H8P0)
DescriptionPolyprenol reductase
Chromosome4
Location4q12 (56212276 ~ 56239263) to Ensembl
Sequene Features : Isoforms 1, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 7 more...
.cholestenone 5-alpha-reductase activity
.oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
.3-oxo-5-alpha-steroid 4-dehydrogenase activity
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 31 0
2014-09-19protein level
1 25 0
2014-05-27protein level
1 25 0
2014-02-25protein level
1 25 0
2013-12-09protein level
1 17 0
2013-11-01protein level
1 16 0
2013-09-12protein level
1 16 0
2013-08-17protein level
1 16 0
2013-07-15protein level
1 11 0
2013-06-11protein level
1 11 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 6 0
2012-10-07protein level
1 6 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H8P0-1
10 0 0 36496.9621
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone13
brain5
cervix41
connective tissue53
embryonic tissue4
eye38
heart22
intestine12
kidney33
liver4
lung23
lymph node11
mammary gland72
muscle9
ovary49
pancreas23
pharynx24
placenta38
prostate36
skin47
stomach10
testis9
thymus12
thyroid42
trachea19
uterus38
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor96
cervical tumor57
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
glioma18
head and neck tumor14
kidney tumor58
leukemia21
liver tumor10
lung tumor19
non-neoplasia20
ovarian tumor65
pancreatic tumor47
primitive neuroectodermal tumor of the CNS47
prostate cancer48
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor47
uterine tumor55
Developmental Stage
TissuesTPM*
adult30
blastocyst16
fetus17
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.6
adrenal gland8.7
appendix6
bone marrow4.3
cerebral cortex8.6
colon11.2
duodenum4.7
esophagus7.5
gallbladder19.1
heart muscle4.7
kidney10.9
liver7.8
lung8.8
lymph node4
ovary2.2
pancreas10.4
placenta5.8
prostate6.7
salivary gland4.3
skin9.9
small intestine6.4
spleen6.2
stomach13.4
testis3.1
thyroid gland5
urinary bladder10.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611715, gene) Steroid 5-alpha-reductase 3; SRD5A3OMIM
2(#612379, phenotype) Congenital disorder of glycosylation, type iq; CDG1QOMIM
3(#612713, phenotype) Kahrizi syndrome; KHRZOMIM


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