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> Protein (NX_Q9H8S9)
Protein (NX_Q9H8S9)
Protein
Gene SymbolMOB1A to neXtProt (NX_Q9H8S9)
DescriptionMOB kinase activator 1A
Chromosome2
Location2p13.1 (74379655 ~ 74406025) to Ensembl
Sequene Features : Isoforms 2, Variants 5, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hippo signaling .metal ion binding .extracellular exosome
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 5 7
2014-09-19protein level
2 8 7
2014-05-27protein level
2 8 12
2014-02-25protein level
2 7 12
2013-12-09protein level
2 5 12
2013-11-01protein level
2 4 10
2013-09-12protein level
2 4 10
2013-08-17protein level
2 4 10
2013-07-15protein level
2 2 7
2013-06-11protein level
2 2 7
2013-02-12protein level
2 0 14
2012-12-20protein level
2 1 14
2012-10-30protein level
2 2 14
2012-10-07protein level
2 2 8
2012-08-24protein level
2 2 8
2012-07-28protein level
2 2 8
2012-06-08protein level
2 4 8
2012-05-07protein level
2 4 8
2012-04-10protein level
2 4 8
2012-01-13protein level
2 2 8
2011-12-20protein level
2 2 8
2011-11-11protein level
2 2 8
2011-08-23protein level
2 2 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H8S9-1
1 2 6 25063.5385
NX_Q9H8S9-2
1 2 4 16917.2263
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748229,EBI-444209 LATS1  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.cytoplasmic sequestering of protein
  + 11 more...
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.microtubule organizing center
.spindle pole
2 EBI-748229,EBI-743494 TDO2  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tryptophan catabolic process to acetyl-CoA
  + 2 more...
.metal ion binding
.heme binding
.oxygen binding
  + 2 more...
.cytosol
3 EBI-748229,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-748229,EBI-458376 STK38  
  .negative regulation of MAP kinase activity
.intracellular signal transduction
.protein phosphorylation
.cellular protein modification process
.mitogen-activated protein kinase kinase kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.MLL5-L complex
.cytoplasm
.nucleus
5 EBI-748229,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
6 EBI-748229,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
7 EBI-748229,EBI-7247651 CMTM3  
  .positive regulation of B cell receptor signaling pathway
.chemotaxis
.N/A .nuclear membrane
.integral component of membrane
.cytoplasm
.extracellular space
8 EBI-748229,EBI-3506895 LATS2  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.regulation of organ growth
  + 9 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.microtubule organizing center
.cytoplasm
  + 2 more...
9 EBI-748229,EBI-8638992 FAM118A  
  .N/A .N/A .integral component of membrane
10 EBI-748229,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
11 EBI-748229,EBI-991501 STK38L  
  .regulation of cellular component organization
.intracellular signal transduction
.protein phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.membrane
.actin cytoskeleton
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland121
ascites50
bladder167
blood40
bone97
bone marrow20
brain53
cervix61
connective tissue33
embryonic tissue126
esophagus198
eye33
heart44
intestine47
kidney109
liver48
lung95
lymph112
lymph node378
mammary gland125
mouth60
muscle56
ovary78
pancreas84
parathyroid48
pituitary gland181
placenta56
prostate36
skin113
spleen37
stomach156
testis89
thymus87
tonsil117
trachea115
umbilical cord145
uterus90
vascular58
Health State
TissuesTPM*
normal76
bladder carcinoma56
breast (mammary gland) tumor139
cervical tumor57
chondrosarcoma108
colorectal tumor35
esophageal tumor173
gastrointestinal tumor101
germ cell tumor113
glioma55
head and neck tumor29
kidney tumor58
leukemia95
liver tumor83
lung tumor58
lymphoma138
non-neoplasia10
ovarian tumor65
pancreatic tumor66
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma107
skin tumor103
soft tissue/muscle tissue tumor103
uterine tumor22
Developmental Stage
TissuesTPM*
adult76
embryoid body200
blastocyst81
neonate193
fetus71
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.9
adrenal gland28.4
appendix75.8
bone marrow59.4
cerebral cortex14.3
colon48.3
duodenum46.4
esophagus47.8
gallbladder42.4
heart muscle22.4
kidney45.2
liver17.3
lung38.5
lymph node98.2
ovary34.4
pancreas8.5
placenta32.1
prostate30
salivary gland17.4
skin34.9
small intestine46.9
spleen62.8
stomach40.3
testis29.3
thyroid gland39.5
urinary bladder58.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609281, gene) Mob1-like protein 1b; MOBKL1BOMIM


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