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> Protein (NX_Q9H8W4)
Protein (NX_Q9H8W4)
Protein
Gene SymbolPLEKHF2 to neXtProt (NX_Q9H8W4)
DescriptionPleckstrin homology domain-containing family F member 2
Chromosome8
Location8q22.1 (96146032 ~ 96168912) to Ensembl
Sequene Features : Isoforms 1, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 28 8
2014-09-19protein level
1 20 8
2014-05-27protein level
1 20 8
2014-02-25protein level
1 20 8
2013-12-09protein level
1 20 8
2013-11-01protein level
1 19 8
2013-09-12protein level
1 19 8
2013-08-17protein level
1 19 8
2013-07-15protein level
1 9 7
2013-06-11protein level
1 9 7
2013-02-12protein level
1 5 3
2012-12-20protein level
1 5 3
2012-10-30protein level
1 4 3
2012-10-07protein level
1 4 3
2012-08-24protein level
1 4 3
2012-07-28protein level
1 4 3
2012-06-08protein level
1 4 3
2012-05-07protein level
1 6 3
2012-04-10protein level
1 6 3
2012-01-13protein level
1 1 3
2011-12-20protein level
1 1 3
2011-11-11protein level
1 1 3
2011-08-23protein level
1 1 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H8W4-1
14 0 0 27779.7568
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742388,EBI-743566 TRAPPC3  
  .vesicle-mediated transport .N/A .Golgi apparatus
.endoplasmic reticulum
2 EBI-742388,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
3 EBI-742388,EBI-476431 PRKAR1A  
  .negative regulation of cAMP-dependent protein kinase activity
.cellular response to glucagon stimulus
.cardiac muscle cell proliferation
  + 20 more...
.protein kinase A catalytic subunit binding
.ubiquitin protein ligase binding
.cAMP binding
  + 2 more...
.ciliary base
.protein complex
.neuromuscular junction
  + 5 more...
4 EBI-742388,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-742388,EBI-743686 S100A1  
  .positive regulation of voltage-gated calcium channel activity
.intracellular signal transduction
.substantia nigra development
  + 2 more...
.ATPase binding
.S100 protein binding
.protein homodimerization activity
  + 2 more...
.protein complex
.neuron projection
.M band
  + 3 more...
6 EBI-742388,EBI-718281 GFER  
  .cellular protein metabolic process
.protein targeting to mitochondrion
.flavin adenine dinucleotide binding
.thiol oxidase activity
.protein disulfide oxidoreductase activity
.mitochondrial intermembrane space
.mitochondrion
.cytoplasm
.extracellular region
7 EBI-742388,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
8 EBI-742388,EBI-745901 SEPT6  
  .viral process
.cytokinesis
.GTP binding .axon terminus
.cleavage furrow
.septin complex
  + 4 more...
9 EBI-742388,EBI-741220 SEPT2  
  .cell division
.cilium assembly
.regulation of protein localization
  + 4 more...
.enzyme regulator activity
.GTP binding
.extracellular exosome
.ciliary membrane
.perinuclear region of cytoplasm
  + 12 more...
10 EBI-742388,EBI-8481036 RSPO2  
  .positive regulation of canonical Wnt signaling pathway
.trachea cartilage morphogenesis
.epithelial tube branching involved in lung morphogenesis
  + 6 more...
.heparin binding
.receptor binding
.G-protein coupled receptor binding
.cell surface
.extracellular space
.extracellular region
11 EBI-742388,EBI-6658150 NPM2  
  .protein homooligomerization
.positive regulation of meiotic nuclear division
.positive regulation of DNA replication
  + 6 more...
.histone binding
.chromatin binding
.nucleic acid binding
.nucleus
.nuclear chromatin
.cytoplasmic chromatin
12 EBI-742388,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
13 EBI-742388,EBI-2349758 GPBP1  
  .positive regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity
.DNA binding
.intracellular membrane-bounded organelle
.plasma membrane
.cytoplasm
.nucleolus
14 EBI-742388,EBI-8643207 ZNF398  
  .positive regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
15 EBI-742388,EBI-10178113 BSCL2  
  .negative regulation of lipid catabolic process
.fat cell differentiation
.lipid particle organization
  + 2 more...
.N/A .integral component of endoplasmic reticulum membrane
16 EBI-742388,EBI-3916242 ACY3  
  .small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
17 EBI-742388,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
18 EBI-742388,EBI-721909 S100A13  
  .response to electrical stimulus
.interleukin-1 alpha secretion
.cytokine secretion
  + 5 more...
.RAGE receptor binding
.protein homodimerization activity
.fibroblast growth factor binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.mast cell granule
  + 4 more...
19 EBI-742388,EBI-5773072 FRMD8  
  .N/A .N/A .cytoskeleton
20 EBI-742388,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
21 EBI-742388,EBI-399266 MEAF6  
  .histone H3-K14 acetylation
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 5 more...
.N/A .MOZ/MORF histone acetyltransferase complex
.NuA4 histone acetyltransferase complex
.centrosome
  + 3 more...
22 EBI-742388,EBI-741953 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
23 EBI-742388,EBI-740282 FBXO28  
  .N/A .N/A .N/A
24 EBI-742388,EBI-10309345 TXNL4B  
  .mitotic nuclear division
.spliceosomal complex assembly
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
25 EBI-742388,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
26 EBI-742388,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
27 EBI-742388,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
28 EBI-742388,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
29 EBI-742388,EBI-2548259 SETBP1  
  .N/A .DNA binding .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood49
bone marrow20
brain13
connective tissue6
embryonic tissue18
esophagus49
eye23
heart33
intestine25
kidney47
liver29
lung23
lymph node144
mammary gland85
muscle9
nerve64
pancreas37
placenta35
skin18
stomach31
testis22
thymus25
thyroid21
tonsil117
trachea19
uterus17
vascular38
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor139
chondrosarcoma12
esophageal tumor57
gastrointestinal tumor25
germ cell tumor7
glioma9
leukemia10
lymphoma27
non-neoplasia31
pancreatic tumor57
skin tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult27
embryoid body14
blastocyst16
neonate32
fetus17
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.1
adrenal gland7
appendix23.6
bone marrow51.8
cerebral cortex5.7
colon17.2
duodenum12.5
esophagus16.4
gallbladder13.1
heart muscle7.1
kidney20.9
liver7.7
lung17.5
lymph node52.8
ovary7.3
pancreas5.9
placenta16.3
prostate8.6
salivary gland9.1
skin17.4
small intestine13.3
spleen20.4
stomach21.2
testis12.1
thyroid gland10.3
urinary bladder19.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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