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> Protein (NX_Q9H8Y8)
Protein (NX_Q9H8Y8)
Protein
Gene SymbolGORASP2 to neXtProt (NX_Q9H8Y8)
DescriptionGolgi reassembly-stacking protein 2
Chromosome2
Location2q31.1 (171784974 ~ 171823639) to Ensembl
Sequene Features : Isoforms 3, Variants 57, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 57 12
2014-09-19protein level
3 39 13
2014-05-27protein level
3 39 12
2014-02-25protein level
2 38 12
2013-12-09protein level
2 33 12
2013-11-01protein level
2 32 12
2013-09-12protein level
2 32 12
2013-08-17protein level
2 32 12
2013-07-15protein level
2 16 12
2013-06-11protein level
2 16 12
2013-02-12protein level
2 9 21
2012-12-20protein level
2 8 21
2012-10-30protein level
2 9 21
2012-10-07protein level
2 9 12
2012-08-24protein level
2 9 12
2012-07-28protein level
2 9 12
2012-06-08protein level
2 17 12
2012-05-07protein level
2 14 12
2012-04-10protein level
2 14 12
2012-01-13protein level
2 16 12
2011-12-20protein level
2 16 12
2011-11-11protein level
2 16 12
2011-08-23protein level
2 16 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H8Y8-1
2 12 1 47115.8728
NX_Q9H8Y8-2
0 11 0 39743.1249
NX_Q9H8Y8-3
2 12 1 48643.5781
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739467,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
2 EBI-739467,EBI-2130415 TRIM38  
  .protein K48-linked ubiquitination
.interferon-gamma-mediated signaling pathway
.positive regulation of NF-kappaB transcription factor activity
  + 8 more...
.ligase activity
.zinc ion binding
.signal transducer activity
.cytosol
3 EBI-739467,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-739467,EBI-742764 PDE9A  
  .cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
5 EBI-739467,EBI-6875961 CRYAA  
  .protein homooligomerization
.response to stimulus
.negative regulation of apoptotic process
  + 2 more...
.unfolded protein binding
.metal ion binding
.identical protein binding
.structural constituent of eye lens
.extracellular exosome
.cytoplasm
.nucleus
6 EBI-739467,EBI-1044287 ODC1  
  .small molecule metabolic process
.regulation of protein catabolic process
.cellular nitrogen compound metabolic process
  + 6 more...
.protein homodimerization activity
.ornithine decarboxylase activity
.cytosol
.cytoplasm
7 EBI-739467,EBI-349854 CFTR  
  .positive regulation of voltage-gated chloride channel activity
.chloride transmembrane transport
.cellular response to cAMP
  + 20 more...
.PDZ domain binding
.enzyme binding
.chloride channel inhibitor activity
  + 6 more...
.extracellular exosome
.recycling endosome
.protein complex
  + 11 more...
8 EBI-739467,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
9 EBI-739467,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
10 EBI-739467,EBI-748336 PRDX3  
  .regulation of mitochondrial membrane potential
.positive regulation of NF-kappaB transcription factor activity
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 14 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.protein kinase binding
.kinase binding
  + 3 more...
.extracellular exosome
.cytosol
.early endosome
  + 3 more...
11 EBI-739467,EBI-739870 DCTD  
  .nucleobase-containing small molecule metabolic process
.pyrimidine nucleoside biosynthetic process
.small molecule metabolic process
  + 3 more...
.zinc ion binding
.dCMP deaminase activity
.extracellular exosome
.cytosol
12 EBI-739467,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
13 EBI-739467,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
14 EBI-739467,EBI-10211517 RGS3  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.inactivation of MAPK activity
.GTPase activator activity .plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
15 EBI-739467,EBI-745846 SCAND1  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
16 EBI-739467,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
17 EBI-739467,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
18 EBI-739467,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
19 EBI-739467,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
20 EBI-739467,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
21 EBI-739467,EBI-491065 EIF2B1  
  .cellular response to stimulus
.cellular protein metabolic process
.positive regulation of GTPase activity
  + 9 more...
.enzyme regulator activity
.GDP binding
.GTP binding
.translation initiation factor activity
.membrane
.plasma membrane
.eukaryotic translation initiation factor 2B complex
  + 2 more...
22 EBI-739467,EBI-930865 DMC1  
  .female gamete generation
.spermatid development
.spermatogenesis
  + 7 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.chromosome
.nucleus
.condensed nuclear chromosome
.chromosome, telomeric region
23 EBI-739467,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
24 EBI-739467,EBI-1104711 DPYSL2  
  .synaptic vesicle transport
.response to drug
.response to cocaine
  + 11 more...
.dihydropyrimidinase activity .extracellular exosome
.protein complex
.terminal bouton
  + 7 more...
25 EBI-739467,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
26 EBI-739467,EBI-10241443 CCDC153  
  .N/A .N/A .N/A
27 EBI-739467,EBI-725982 MORN2  
  .N/A .N/A .N/A
28 EBI-739467,EBI-946029 C1orf94  
  .N/A .N/A .N/A
29 EBI-739467,EBI-3923644 STOX1  
  .positive regulation of cyclin-dependent protein kinase activity
.regulation of response to oxidative stress
.regulation of mitochondrial DNA metabolic process
  + 11 more...
.RNA polymerase II regulatory region sequence-specific DNA binding .centrosome
.cytoplasm
.nucleolus
  + 2 more...
30 EBI-739467,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
31 EBI-739467,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
32 EBI-739467,EBI-8468945 GABPB2  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.protein heterodimerization activity
.transcription regulatory region DNA binding
.nucleus
33 EBI-739467,EBI-713221 ENOX1  
  .rhythmic process .oxidoreductase activity
.nucleic acid binding
.nucleotide binding
.plasma membrane
.extracellular space
34 EBI-739467,EBI-3916242 ACY3  
  .small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
35 EBI-739467,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
36 EBI-739467,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
37 EBI-739467,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
38 EBI-739467,EBI-8644516 TEKT3  
  .regulation of fertilization
.cilium morphogenesis
.sperm motility
.N/A .extracellular exosome
.sperm flagellum
.microtubule
  + 2 more...
39 EBI-739467,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
40 EBI-739467,EBI-7357329 DUSP21  
  .peptidyl-tyrosine dephosphorylation .MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.extrinsic component of mitochondrial inner membrane
.mitochondrial matrix
.cytoplasm
.nucleus
41 EBI-739467,EBI-10308705 AAMDC  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of fat cell differentiation
.negative regulation of apoptotic process
.N/A .cytoplasm
42 EBI-739467,EBI-10311936 JADE2  
  .SMAD protein signal transduction
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 2 more...
.zinc ion binding .extracellular exosome
.nucleoplasm
.histone acetyltransferase complex
43 EBI-739467,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
44 EBI-739467,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
45 EBI-739467,EBI-2688184 ZNF148  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.substantia nigra development
  + 6 more...
.metal ion binding
.sequence-specific DNA binding
.double-stranded DNA binding
  + 2 more...
.Golgi apparatus
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland333
ascites376
bladder234
blood155
bone97
bone marrow82
brain235
cervix144
connective tissue275
ear62
embryonic tissue89
esophagus248
eye143
heart189
intestine327
kidney185
larynx213
liver194
lung167
lymph22
lymph node111
mammary gland92
mouth317
muscle28
nerve128
ovary167
pancreas79
parathyroid97
pituitary gland60
placenta187
prostate94
salivary gland98
skin265
spleen224
stomach250
testis197
thymus238
thyroid85
tonsil293
trachea231
umbilical cord290
uterus262
vascular561
Health State
TissuesTPM*
normal197
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor173
chondrosarcoma144
colorectal tumor453
esophageal tumor289
gastrointestinal tumor253
germ cell tumor379
glioma139
head and neck tumor171
kidney tumor188
leukemia137
liver tumor354
lung tumor126
lymphoma96
non-neoplasia300
ovarian tumor118
pancreatic tumor104
primitive neuroectodermal tumor of the CNS157
prostate cancer28
retinoblastoma129
skin tumor79
soft tissue/muscle tissue tumor127
uterine tumor122
Developmental Stage
TissuesTPM*
adult200
embryoid body142
blastocyst65
neonate901
fetus161
infant170
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.4
adrenal gland43
appendix37
bone marrow37.4
cerebral cortex29.1
colon50.6
duodenum33.5
esophagus46.6
gallbladder42.2
heart muscle44.3
kidney30.5
liver27.7
lung34.7
lymph node39.9
ovary44
pancreas33.2
placenta58.4
prostate36.1
salivary gland47
skin32.4
small intestine35.8
spleen31.1
stomach43.3
testis54.2
thyroid gland54.9
urinary bladder53.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungLow
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skin 1High
skin 2High
small intestineHigh
soft tissue 1High
soft tissue 2High
spleenLow
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608693, gene) Golgi reassembly stacking protein 2; GORASP2OMIM


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