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> Protein (NX_Q9H9E3)
Protein (NX_Q9H9E3)
Protein
Gene SymbolCOG4 to neXtProt (NX_Q9H9E3)
DescriptionConserved oligomeric Golgi complex subunit 4
Chromosome16
Location16q22.1 (70514471 ~ 70557468) to Ensembl
Sequene Features : Isoforms 3, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi vesicle prefusion complex stabilization
.protein transport
.Golgi organization
.retrograde vesicle-mediated transport, Golgi to ER
.N/A .Golgi transport complex
.Golgi membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 96 3
2014-09-19protein level
3 78 3
2014-05-27protein level
3 78 3
2014-02-25protein level
3 77 3
2013-12-09protein level
3 60 3
2013-11-01protein level
3 57 3
2013-09-12protein level
3 57 3
2013-08-17protein level
3 57 3
2013-07-15protein level
3 42 1
2013-06-11protein level
3 42 1
2013-02-12protein level
3 23 8
2012-12-20protein level
3 23 8
2012-10-30protein level
3 28 8
2012-10-07protein level
3 28 4
2012-08-24protein level
3 19 4
2012-07-28protein level
3 18 4
2012-06-08protein level
3 26 4
2012-05-07protein level
3 26 4
2012-04-10protein level
3 26 4
2012-01-13protein level
3 16 4
2011-12-20protein level
3 16 4
2011-11-11protein level
3 16 4
2011-08-23protein level
3 16 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H9E3-1
0 38 0 89026.1554
NX_Q9H9E3-2
1 18 0 38220.5411
NX_Q9H9E3-3
0 33 0 81046.2062
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-368382,EBI-389534 COG7  
  .protein stabilization
.protein localization to Golgi apparatus
.protein localization to organelle
  + 3 more...
.N/A .intracellular membrane-bounded organelle
.Golgi transport complex
.Golgi apparatus
  + 2 more...
2 EBI-368382,EBI-714206 STX5  
  .regulation of Golgi organization
.Golgi disassembly
.vesicle fusion with Golgi apparatus
  + 7 more...
.protein N-terminus binding
.SNAP receptor activity
.SNARE binding
.endoplasmic reticulum-Golgi intermediate compartment membrane
.vesicle
.SNARE complex
  + 5 more...
3 EBI-368382,EBI-389449 COG2  
  .oligosaccharide biosynthetic process
.Golgi organization
.intra-Golgi vesicle-mediated transport
  + 2 more...
.protein transporter activity .Golgi transport complex
.cytosol
.Golgi stack
.Golgi membrane
4 EBI-368382,EBI-368371 COG1  
  .protein transport
.Golgi organization
.intra-Golgi vesicle-mediated transport
.N/A .Golgi transport complex
.Golgi apparatus
.Golgi membrane
5 EBI-368382,EBI-722569 SCFD1  
  .negative regulation of autophagic vacuole assembly
.regulation of ER to Golgi vesicle-mediated transport
.regulation of protein transport
  + 8 more...
.syntaxin binding .Golgi cisterna membrane
.Golgi transport complex
.plasma membrane
  + 3 more...
6 EBI-368382,EBI-389502 COG5  
  .protein transport
.intra-Golgi vesicle-mediated transport
.N/A .Golgi transport complex
.membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland30
ascites251
bladder33
blood163
bone55
bone marrow20
brain172
cervix164
connective tissue46
embryonic tissue79
eye129
heart22
intestine81
kidney132
liver48
lung104
lymph90
lymph node77
mammary gland66
mouth181
muscle131
nerve64
ovary59
pancreas42
pharynx147
placenta74
prostate116
salivary gland49
skin123
spleen187
stomach83
testis186
thymus238
thyroid128
tonsil235
trachea154
umbilical cord290
uterus112
vascular212
Health State
TissuesTPM*
normal107
adrenal tumor79
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma193
colorectal tumor71
gastrointestinal tumor135
germ cell tumor258
glioma121
head and neck tumor112
kidney tumor217
leukemia74
liver tumor72
lung tumor68
lymphoma110
non-neoplasia41
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS275
prostate cancer163
retinoblastoma172
skin tumor127
soft tissue/muscle tissue tumor103
uterine tumor122
Developmental Stage
TissuesTPM*
adult86
embryoid body85
blastocyst97
neonate289
fetus145
infant42
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.7
adrenal gland23.6
appendix27.5
bone marrow12.4
cerebral cortex24.7
colon27.4
duodenum24.5
esophagus31.3
gallbladder24.6
heart muscle22.4
kidney22.5
liver13.2
lung26.3
lymph node31.8
ovary26.6
pancreas8.1
placenta27.5
prostate21.4
salivary gland18.2
skin31.3
small intestine25.5
spleen31.7
stomach25.7
testis37.9
thyroid gland26
urinary bladder26.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606976, gene) Component of oligomeric golgi complex 4; COG4OMIM
2(#613489, phenotype) Congenital disorder of glycosylation, type iij; CDG2JOMIM


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