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> Protein (NX_Q9H9H4)
Protein (NX_Q9H9H4)
Protein
Gene SymbolVPS37B to neXtProt (NX_Q9H9H4)
DescriptionVacuolar protein sorting-associated protein 37B
Chromosome12
Location12q24.31 (123349882 ~ 123380991) to Ensembl
Sequene Features : Isoforms 1, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 35 0
2014-09-19protein level
1 28 0
2014-05-27protein level
1 28 0
2014-02-25protein level
1 27 0
2013-12-09protein level
1 17 0
2013-11-01protein level
1 17 0
2013-09-12protein level
1 17 0
2013-08-17protein level
1 17 0
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 6 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 4 0
2012-10-07protein level
1 4 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9H9H4-1
15 0 0 31287.3995
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4400866,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-4400866,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
3 EBI-4400866,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
4 EBI-4400866,EBI-10209725 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
5 EBI-4400866,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-4400866,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
7 EBI-4400866,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
8 EBI-4400866,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
9 EBI-4400866,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
10 EBI-4400866,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
11 EBI-4400866,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
12 EBI-4400866,EBI-358489 SMARCD1  
  .chromatin-mediated maintenance of transcription
.nervous system development
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.protein complex scaffold
.transcription coactivator activity
.nBAF complex
.npBAF complex
.SWI/SNF complex
13 EBI-4400866,EBI-722667 SH3YL1  
  .regulation of ruffle assembly
.phosphatidylinositol biosynthetic process
.phosphatidylinositol binding
.phosphatase binding
.ruffle membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites100
bladder33
blood49
bone55
bone marrow61
brain43
cervix61
connective tissue26
embryonic tissue79
eye105
heart67
intestine81
kidney37
liver9
lung77
lymph node55
mammary gland33
mouth15
muscle103
nerve64
ovary39
pancreas112
placenta49
prostate68
salivary gland98
skin56
spleen74
stomach73
testis27
thyroid21
trachea19
uterus64
vascular58
Health State
TissuesTPM*
normal49
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma108
colorectal tumor79
gastrointestinal tumor101
germ cell tumor34
glioma149
head and neck tumor29
kidney tumor87
leukemia10
liver tumor10
lung tumor38
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor114
primitive neuroectodermal tumor of the CNS23
prostate cancer115
retinoblastoma86
skin tumor63
soft tissue/muscle tissue tumor39
uterine tumor144
Developmental Stage
TissuesTPM*
adult61
embryoid body128
blastocyst97
fetus53
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.6
adrenal gland18.3
appendix12.8
bone marrow23.8
cerebral cortex11.1
colon23.2
duodenum12.8
esophagus31.5
gallbladder18.1
heart muscle8.2
kidney10.2
liver3.8
lung22.4
lymph node12.3
ovary4.2
pancreas10.5
placenta10.5
prostate9.6
salivary gland19.1
skin8.6
small intestine16.8
spleen18.9
stomach25.2
testis15.4
thyroid gland16.3
urinary bladder14.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610037, gene) Vacuolar protein sorting 37, yeast, homolog of, b; VPS37BOMIM


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