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> Protein (NX_Q9HAN9)
Protein (NX_Q9HAN9)
Protein
Gene SymbolNMNAT1 to neXtProt (NX_Q9HAN9)
DescriptionNicotinamide mononucleotide adenylyltransferase 1
Chromosome1
Location1p36.22 (10003486 ~ 10045559) to Ensembl
Sequene Features : Isoforms 1, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.NAD metabolic process
.NAD biosynthetic process
  + 2 more...
.ATP binding
.nicotinate-nucleotide adenylyltransferase activity
.nicotinamide-nucleotide adenylyltransferase activity
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 52 1
2014-09-19protein level
1 49 1
2014-05-27protein level
1 49 1
2014-02-25protein level
1 49 1
2013-12-09protein level
1 42 1
2013-11-01protein level
1 42 1
2013-09-12protein level
1 42 1
2013-08-17protein level
1 42 1
2013-07-15protein level
1 35 1
2013-06-11protein level
1 35 1
2013-02-12protein level
1 32 2
2012-12-20protein level
1 32 2
2012-10-30protein level
1 6 2
2012-10-07protein level
1 6 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 8 2
2012-05-07protein level
1 8 2
2012-04-10protein level
1 8 2
2012-01-13protein level
1 4 2
2011-12-20protein level
1 4 2
2011-11-11protein level
1 4 2
2011-08-23protein level
1 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HAN9-1
15 0 0 31912.4847
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3917542,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
2 EBI-3917542,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain6
cervix20
connective tissue6
embryonic tissue4
eye19
heart33
intestine21
kidney14
lung8
mammary gland13
muscle28
ovary9
pancreas14
pharynx24
prostate5
salivary gland49
spleen18
testis20
thyroid21
trachea19
umbilical cord72
uterus4
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor21
colorectal tumor26
germ cell tumor11
glioma18
head and neck tumor7
kidney tumor14
leukemia21
lung tumor9
non-neoplasia20
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult7
blastocyst16
neonate32
fetus12
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.2
adrenal gland5.6
appendix5.5
bone marrow1.1
cerebral cortex3.6
colon10.3
duodenum6.2
esophagus5.3
gallbladder4.3
heart muscle9.8
kidney8.5
liver3.5
lung4
lymph node4.6
ovary3.6
pancreas1.9
placenta3.9
prostate4.9
salivary gland4
skin3.8
small intestine7.1
spleen4.4
stomach4.5
testis4.4
thyroid gland9.4
urinary bladder6.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#608553, phenotype) Leber congenital amaurosis 9; LCA9OMIM
2(*608700, gene) Nicotinamide nucleotide adenylyltransferase 1; NMNAT1OMIM


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