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> Protein (NX_Q9HAT0)
Protein (NX_Q9HAT0)
Protein
Gene SymbolROPN1 to neXtProt (NX_Q9HAT0)
DescriptionRopporin-1A
Chromosome3
Location3q21.1 (123687368 ~ 123711025) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 0
2014-09-19protein level
2 19 0
2014-05-27protein level
2 19 0
2014-02-25protein level
2 19 0
2013-12-09protein level
2 15 0
2013-11-01protein level
2 15 0
2013-09-12protein level
2 15 0
2013-08-17protein level
2 15 0
2013-07-15protein level
2 8 0
2013-06-11protein level
2 8 0
2013-02-12protein level
2 6 0
2012-12-20protein level
2 6 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 4 0
2012-04-10protein level
2 4 0
2012-01-13protein level
2 2 0
2011-12-20protein level
2 2 0
2011-11-11protein level
2 2 0
2011-08-23protein level
2 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HAT0-1
6 0 6 23877.2766
NX_Q9HAT0-2
2 0 1 6706.5985
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1378139,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-1378139,EBI-10185182 AKAP7  
  .positive regulation of delayed rectifier potassium channel activity
.positive regulation of potassium ion transmembrane transport
.cellular response to cAMP
  + 5 more...
.protein kinase A binding .lateral plasma membrane
.apical plasma membrane
.plasma membrane
3 EBI-1378139,EBI-5357290 TULP3  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.ganglion development
.smoothened signaling pathway involved in dorsal/ventral neural tube patterning
  + 14 more...
.phosphatidylinositol binding
.protein complex binding
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
.ciliary base
.primary cilium
.axoneme
  + 5 more...
4 EBI-1378139,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
5 EBI-1378139,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
6 EBI-1378139,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
7 EBI-1378139,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
8 EBI-1378139,EBI-1377865 SPA17  
  .binding of sperm to zona pellucida
.single fertilization
.spermatogenesis
.epithelial cilium movement
.calmodulin binding .sperm principal piece
.primary cilium
.sperm fibrous sheath
  + 3 more...
9 EBI-1378139,EBI-750390 CNST  
  .positive regulation of Golgi to plasma membrane protein transport
.negative regulation of phosphatase activity
.connexin binding
.phosphatase binding
.protein complex
.transport vesicle
.integral component of membrane
  + 3 more...
10 EBI-1378139,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
11 EBI-1378139,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
12 EBI-1378139,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
13 EBI-1378139,EBI-716589 UBE2W  
  .cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
14 EBI-1378139,EBI-726510 LENG1  
  .N/A .N/A .N/A
15 EBI-1378139,EBI-5452779 POLR3C  
  .defense response to virus
.positive regulation of innate immune response
.innate immune response
  + 7 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
.nucleus
16 EBI-1378139,EBI-746682 GNL3L  
  .ribosome biogenesis
.metabolic process
.poly(A) RNA binding
.GTP binding
.GTPase activity
.membrane
.mitochondrion
.cytoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
connective tissue33
pharynx24
testis98
Health State
TissuesTPM*
normal5
germ cell tumor22
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult3
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
salivary gland5.3
testis139.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleHigh
kidneyLow
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
placentaHigh
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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