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> Protein (NX_Q9HAU4)
Protein (NX_Q9HAU4)
Protein
Gene SymbolSMURF2 to neXtProt (NX_Q9HAU4)
DescriptionE3 ubiquitin-protein ligase SMURF2
Chromosome17
Location17q23.3 (62538413 ~ 62658186) to Ensembl
Sequene Features : Isoforms 1, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of trophoblast cell migration
.positive regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 11 more...
.ubiquitin protein ligase activity
.SMAD binding
.identical protein binding
  + 2 more...
.membrane raft
.plasma membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 73 1
2014-09-19protein level
1 52 1
2014-05-27protein level
1 52 1
2014-02-25protein level
1 52 1
2013-12-09protein level
1 40 1
2013-11-01protein level
1 37 1
2013-09-12protein level
1 37 1
2013-08-17protein level
1 37 1
2013-07-15protein level
1 22 1
2013-06-11protein level
1 22 1
2013-02-12protein level
1 13 0
2012-12-20protein level
1 12 0
2012-10-30protein level
1 17 0
2012-10-07protein level
1 17 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 23 0
2012-05-07protein level
1 23 0
2012-04-10protein level
1 23 0
2012-01-13protein level
1 21 0
2011-12-20protein level
1 21 0
2011-11-11protein level
1 21 0
2011-08-23protein level
1 21 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HAU4-1
30 0 6 86141.4235
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396727,EBI-413034 UBB  
  .positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of neuron death
.programmed necrotic cell death
  + 96 more...
.N/A .extracellular exosome
.neuronal cell body
.neuron projection
  + 6 more...
2 EBI-396727,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
3 EBI-396727,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
4 EBI-396727,EBI-6144096 FBXL15  
  .SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.positive regulation of BMP signaling pathway
.bone mineralization
  + 3 more...
.N/A .SCF ubiquitin ligase complex
.cytoplasm
5 EBI-396727,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
blood8
bone27
bone marrow20
brain9
cervix41
connective tissue67
ear124
embryonic tissue37
esophagus49
eye47
heart44
intestine30
kidney14
larynx42
liver58
lung62
lymph22
lymph node77
mouth30
muscle18
nerve64
pancreas37
pharynx24
pituitary gland60
placenta52
prostate15
salivary gland49
skin80
spleen56
stomach167
testis27
thymus37
thyroid42
trachea38
umbilical cord145
uterus8
vascular135
Health State
TissuesTPM*
normal48
cervical tumor28
chondrosarcoma72
colorectal tumor44
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor37
kidney tumor14
leukemia31
liver tumor83
lung tumor29
lymphoma13
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer28
retinoblastoma43
skin tumor47
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult31
embryoid body100
blastocyst16
neonate64
fetus78
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.2
adrenal gland9.3
appendix11.8
bone marrow7.5
cerebral cortex8.8
colon9.5
duodenum10.5
esophagus8.1
gallbladder14.7
heart muscle6.1
kidney10.2
liver4.1
lung18.7
lymph node10.6
ovary11.9
pancreas4.4
placenta17.5
prostate11.9
salivary gland8.3
skin11.4
small intestine15.1
spleen9.7
stomach12.2
testis21.4
thyroid gland14.2
urinary bladder12.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605532, gene) Smad-specific e3 ubiquitin protein ligase 2; SMURF2OMIM


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