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	> Protein (NX_Q9HAU4) Protein (NX_Q9HAU4) Protein Gene Symbol SMURF2 to neXtProt (NX_Q9HAU4) Description E3 ubiquitin-protein ligase SMURF2 Chromosome 17 Location 17q23.3 (62538413 ~ 62658186) to Ensembl Sequene Features : Isoforms 1, Variants 73, PTMs 1 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .positive regulation of trophoblast cell migration .positive regulation of canonical Wnt signaling pathway .negative regulation of transcription, DNA-templated   + 11 more... .ubiquitin protein ligase activity .SMAD binding .identical protein binding   + 2 more... .membrane raft .plasma membrane .cytosol   + 4 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 1 73 1 2014-09-19 protein level 1 52 1 2014-05-27 protein level 1 52 1 2014-02-25 protein level 1 52 1 2013-12-09 protein level 1 40 1 2013-11-01 protein level 1 37 1 2013-09-12 protein level 1 37 1 2013-08-17 protein level 1 37 1 2013-07-15 protein level 1 22 1 2013-06-11 protein level 1 22 1 2013-02-12 protein level 1 13 0 2012-12-20 protein level 1 12 0 2012-10-30 protein level 1 17 0 2012-10-07 protein level 1 17 0 2012-08-24 protein level 1 9 0 2012-07-28 protein level 1 9 0 2012-06-08 protein level 1 23 0 2012-05-07 protein level 1 23 0 2012-04-10 protein level 1 23 0 2012-01-13 protein level 1 21 0 2011-12-20 protein level 1 21 0 2011-11-11 protein level 1 21 0 2011-08-23 protein level 1 21 0 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q9HAU4-1 30 0 6 86141.4235 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-396727,EBI-413034 UBB     .positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator .regulation of neuron death .programmed necrotic cell death   + 96 more... .N/A .extracellular exosome .neuronal cell body .neuron projection   + 6 more... 2 EBI-396727,EBI-347161 SMAD3     .positive regulation of extracellular matrix assembly .activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway .extrinsic apoptotic signaling pathway   + 73 more... .R-SMAD binding .co-SMAD binding .transcription regulatory region DNA binding   + 21 more... .SMAD2-SMAD3 protein complex .SMAD protein complex .receptor complex   + 8 more... 3 EBI-396727,EBI-1040141 SMAD2     .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry .response to cholesterol .SMAD protein signal transduction   + 42 more... .R-SMAD binding .I-SMAD binding .co-SMAD binding   + 15 more... .SMAD2-SMAD3 protein complex .SMAD protein complex .activin responsive factor complex   + 6 more... 4 EBI-396727,EBI-6144096 FBXL15     .SCF-dependent proteasomal ubiquitin-dependent protein catabolic process .positive regulation of BMP signaling pathway .bone mineralization   + 3 more... .N/A .SCF ubiquitin ligase complex .cytoplasm 5 EBI-396727,EBI-396669 RNF11     .protein autoubiquitination .protein ubiquitination involved in ubiquitin-dependent protein catabolic process .zinc ion binding .ubiquitin-protein transferase activity .DNA binding .extracellular exosome .recycling endosome .early endosome   + 2 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 77 ascites 25 blood 8 bone 27 bone marrow 20 brain 9 cervix 41 connective tissue 67 ear 124 embryonic tissue 37 esophagus 49 eye 47 heart 44 intestine 30 kidney 14 larynx 42 liver 58 lung 62 lymph 22 lymph node 77 mouth 30 muscle 18 nerve 64 pancreas 37 pharynx 24 pituitary gland 60 placenta 52 prostate 15 salivary gland 49 skin 80 spleen 56 stomach 167 testis 27 thymus 37 thyroid 42 trachea 38 umbilical cord 145 uterus 8 vascular 135 Health State Tissues TPM* normal 48 cervical tumor 28 chondrosarcoma 72 colorectal tumor 44 esophageal tumor 57 gastrointestinal tumor 16 germ cell tumor 15 glioma 9 head and neck tumor 37 kidney tumor 14 leukemia 31 liver tumor 83 lung tumor 29 lymphoma 13 non-neoplasia 41 pancreatic tumor 9 primitive neuroectodermal tumor of the CNS 7 prostate cancer 28 retinoblastoma 43 skin tumor 47 soft tissue/muscle tissue tumor 23 uterine tumor 11 Developmental Stage Tissues TPM* adult 31 embryoid body 100 blastocyst 16 neonate 64 fetus 78 infant 42 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 10.2 adrenal gland 9.3 appendix 11.8 bone marrow 7.5 cerebral cortex 8.8 colon 9.5 duodenum 10.5 esophagus 8.1 gallbladder 14.7 heart muscle 6.1 kidney 10.2 liver 4.1 lung 18.7 lymph node 10.6 ovary 11.9 pancreas 4.4 placenta 17.5 prostate 11.9 salivary gland 8.3 skin 11.4 small intestine 15.1 spleen 9.7 stomach 12.2 testis 21.4 thyroid gland 14.2 urinary bladder 12.4 RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Disease No. Disease Description Ref. 1 (*605532, gene) Smad-specific e3 ubiquitin protein ligase 2; SMURF2 OMIM

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