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Protein |
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Gene Symbol | SMURF2 to neXtProt (NX_Q9HAU4) |
Description | E3 ubiquitin-protein ligase SMURF2 |
Chromosome | 17 |
Location | 17q23.3 (62538413 ~ 62658186) to Ensembl |
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Sequene Features : Isoforms 1, Variants 73, PTMs 1 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.positive regulation of trophoblast cell migration .positive regulation of canonical Wnt signaling pathway .negative regulation of transcription, DNA-templated + 11 more... |
.ubiquitin protein ligase activity .SMAD binding .identical protein binding + 2 more... |
.membrane raft .plasma membrane .cytosol + 4 more... |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 1 |
| 73 |
| 1 |
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2014-09-19 | | protein level | | | | | | | 1 |
| 52 |
| 1 |
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2014-05-27 | | protein level | | | | | | | 1 |
| 52 |
| 1 |
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2014-02-25 | | protein level | | | | | | | 1 |
| 52 |
| 1 |
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2013-12-09 | | protein level | | | | | | | 1 |
| 40 |
| 1 |
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2013-11-01 | | protein level | | | | | | | 1 |
| 37 |
| 1 |
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2013-09-12 | | protein level | | | | | | | 1 |
| 37 |
| 1 |
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2013-08-17 | | protein level | | | | | | | 1 |
| 37 |
| 1 |
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2013-07-15 | | protein level | | | | | | | 1 |
| 22 |
| 1 |
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2013-06-11 | | protein level | | | | | | | 1 |
| 22 |
| 1 |
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2013-02-12 | | protein level | | | | | | | 1 |
| 13 |
| 0 |
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2012-12-20 | | protein level | | | | | | | 1 |
| 12 |
| 0 |
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2012-10-30 | | protein level | | | | | | | 1 |
| 17 |
| 0 |
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2012-10-07 | | protein level | | | | | | | 1 |
| 17 |
| 0 |
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2012-08-24 | | protein level | | | | | | | 1 |
| 9 |
| 0 |
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2012-07-28 | | protein level | | | | | | | 1 |
| 9 |
| 0 |
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2012-06-08 | | protein level | | | | | | | 1 |
| 23 |
| 0 |
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2012-05-07 | | protein level | | | | | | | 1 |
| 23 |
| 0 |
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2012-04-10 | | protein level | | | | | | | 1 |
| 23 |
| 0 |
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2012-01-13 | | protein level | | | | | | | 1 |
| 21 |
| 0 |
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2011-12-20 | | protein level | | | | | | | 1 |
| 21 |
| 0 |
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2011-11-11 | | protein level | | | | | | | 1 |
| 21 |
| 0 |
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2011-08-23 | | protein level | | | | | | | 1 |
| 21 |
| 0 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-396727,EBI-413034 |
UBB |
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.positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator .regulation of neuron death .programmed necrotic cell death + 96 more... |
.N/A |
.extracellular exosome .neuronal cell body .neuron projection + 6 more... |
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2 |
EBI-396727,EBI-347161 |
SMAD3 |
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.positive regulation of extracellular matrix assembly .activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway .extrinsic apoptotic signaling pathway + 73 more... |
.R-SMAD binding .co-SMAD binding .transcription regulatory region DNA binding + 21 more... |
.SMAD2-SMAD3 protein complex .SMAD protein complex .receptor complex + 8 more... |
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3 |
EBI-396727,EBI-1040141 |
SMAD2 |
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.positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry .response to cholesterol .SMAD protein signal transduction + 42 more... |
.R-SMAD binding .I-SMAD binding .co-SMAD binding + 15 more... |
.SMAD2-SMAD3 protein complex .SMAD protein complex .activin responsive factor complex + 6 more... |
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4 |
EBI-396727,EBI-6144096 |
FBXL15 |
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.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process .positive regulation of BMP signaling pathway .bone mineralization + 3 more... |
.N/A |
.SCF ubiquitin ligase complex .cytoplasm |
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5 |
EBI-396727,EBI-396669 |
RNF11 |
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.protein autoubiquitination .protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
.zinc ion binding .ubiquitin-protein transferase activity .DNA binding |
.extracellular exosome .recycling endosome .early endosome + 2 more... |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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adipose tissue | 77 | |
ascites | 25 | |
blood | 8 | |
bone | 27 | |
bone marrow | 20 | |
brain | 9 | |
cervix | 41 | |
connective tissue | 67 | |
ear | 124 | |
embryonic tissue | 37 | |
esophagus | 49 | |
eye | 47 | |
heart | 44 | |
intestine | 30 | |
kidney | 14 | |
larynx | 42 | |
liver | 58 | |
lung | 62 | |
lymph | 22 | |
lymph node | 77 | |
mouth | 30 | |
muscle | 18 | |
nerve | 64 | |
pancreas | 37 | |
pharynx | 24 | |
pituitary gland | 60 | |
placenta | 52 | |
prostate | 15 | |
salivary gland | 49 | |
skin | 80 | |
spleen | 56 | |
stomach | 167 | |
testis | 27 | |
thymus | 37 | |
thyroid | 42 | |
trachea | 38 | |
umbilical cord | 145 | |
uterus | 8 | |
vascular | 135 | |
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Health State | |
Tissues | TPM* | |
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normal | 48 | |
cervical tumor | 28 | |
chondrosarcoma | 72 | |
colorectal tumor | 44 | |
esophageal tumor | 57 | |
gastrointestinal tumor | 16 | |
germ cell tumor | 15 | |
glioma | 9 | |
head and neck tumor | 37 | |
kidney tumor | 14 | |
leukemia | 31 | |
liver tumor | 83 | |
lung tumor | 29 | |
lymphoma | 13 | |
non-neoplasia | 41 | |
pancreatic tumor | 9 | |
primitive neuroectodermal tumor of the CNS | 7 | |
prostate cancer | 28 | |
retinoblastoma | 43 | |
skin tumor | 47 | |
soft tissue/muscle tissue tumor | 23 | |
uterine tumor | 11 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 31 | |
embryoid body | 100 | |
blastocyst | 16 | |
neonate | 64 | |
fetus | 78 | |
infant | 42 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 10.2 | |
adrenal gland | 9.3 | |
appendix | 11.8 | |
bone marrow | 7.5 | |
cerebral cortex | 8.8 | |
colon | 9.5 | |
duodenum | 10.5 | |
esophagus | 8.1 | |
gallbladder | 14.7 | |
heart muscle | 6.1 | |
kidney | 10.2 | |
liver | 4.1 | |
lung | 18.7 | |
lymph node | 10.6 | |
ovary | 11.9 | |
pancreas | 4.4 | |
placenta | 17.5 | |
prostate | 11.9 | |
salivary gland | 8.3 | |
skin | 11.4 | |
small intestine | 15.1 | |
spleen | 9.7 | |
stomach | 12.2 | |
testis | 21.4 | |
thyroid gland | 14.2 | |
urinary bladder | 12.4 | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*605532, gene) Smad-specific e3 ubiquitin protein ligase 2; SMURF2 | OMIM |
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