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> Protein (NX_Q9HC52)
Protein (NX_Q9HC52)
Protein
Gene SymbolCBX8 to neXtProt (NX_Q9HC52)
DescriptionChromobox protein homolog 8
Chromosome17
Location17q25.3 (77765931 ~ 77775482) to Ensembl
Sequene Features : Isoforms 1, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 57 8
2014-09-19protein level
1 39 8
2014-05-27protein level
1 39 8
2014-02-25protein level
1 39 8
2013-12-09protein level
1 32 8
2013-11-01protein level
1 31 8
2013-09-12protein level
1 31 8
2013-08-17protein level
1 31 8
2013-07-15protein level
1 17 8
2013-06-11protein level
1 17 8
2013-02-12protein level
1 12 11
2012-12-20protein level
1 12 11
2012-10-30protein level
1 13 11
2012-10-07protein level
1 13 11
2012-08-24protein level
1 9 11
2012-07-28protein level
1 9 11
2012-06-08protein level
1 9 11
2012-05-07protein level
1 9 11
2012-04-10protein level
1 9 11
2012-01-13protein level
1 7 11
2011-12-20protein level
1 7 11
2011-11-11protein level
1 7 9
2011-08-23protein level
1 7 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HC52-1
18 0 1 43369.3149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712912,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-712912,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-712912,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
4 EBI-712912,EBI-2129767 PCGF2  
  .negative regulation of apoptotic signaling pathway
.cellular response to hydrogen peroxide
.embryonic skeletal system morphogenesis
  + 8 more...
.zinc ion binding
.ubiquitin-protein transferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.PRC1 complex
.PcG protein complex
.nuclear body
  + 4 more...
5 EBI-712912,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
6 EBI-712912,EBI-306876 USP11  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein deubiquitination
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.cytoplasm
.nucleus
7 EBI-712912,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
8 EBI-712912,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-712912,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
10 EBI-712912,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
11 EBI-712912,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
12 EBI-712912,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
13 EBI-712912,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
14 EBI-712912,EBI-2339807 PCGF3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.nucleoplasm
.nucleus
15 EBI-712912,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
16 EBI-712912,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
17 EBI-712912,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
18 EBI-712912,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
19 EBI-712912,EBI-2827999 PCGF5  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.centrosome
.nucleolus
.nucleus
20 EBI-712912,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
21 EBI-712912,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
22 EBI-712912,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
23 EBI-712912,EBI-473189 GPRASP2  
  .N/A .beta-amyloid binding .cytoplasm
24 EBI-712912,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
25 EBI-712912,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
26 EBI-712912,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
27 EBI-712912,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
28 EBI-712912,EBI-749901 PCGF1  
  .histone H2A monoubiquitination
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.protein C-terminus binding
.PcG protein complex
.nucleoplasm
.nucleus
29 EBI-712912,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
30 EBI-712912,EBI-1048026 PCGF6  
  .negative regulation of transcription, DNA-templated .zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 2 more...
.PRC1 complex
.PcG protein complex
.nucleus
31 EBI-712912,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
32 EBI-712912,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
33 EBI-712912,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
bone marrow41
brain2
cervix82
embryonic tissue23
esophagus198
eye19
intestine12
kidney4
larynx42
lung20
mammary gland6
muscle18
pancreas9
placenta7
prostate5
skin14
testis2
uterus4
Health State
TissuesTPM*
normal5
breast (mammary gland) tumor10
colorectal tumor17
esophageal tumor231
germ cell tumor7
head and neck tumor7
leukemia10
lung tumor19
pancreatic tumor19
prostate cancer9
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult8
embryoid body42
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
adrenal gland1.2
appendix2.1
bone marrow1.5
cerebral cortex2.6
colon1.5
duodenum2.3
gallbladder1.5
heart muscle1.2
kidney2.2
liver1
lung1.9
lymph node2
pancreas1
placenta2.1
prostate1.3
salivary gland1.7
skin1.2
small intestine1.6
spleen1.7
stomach2.4
testis4.9
thyroid gland1.6
urinary bladder1.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
kidneyMedium
lateral ventricleLow
lungLow
lymph nodeLow
nasopharynxHigh
oral mucosaLow
pancreasMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineLow
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
testisHigh
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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