Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9HC62)
Protein (NX_Q9HC62)
Protein
Gene SymbolSENP2 to neXtProt (NX_Q9HC62)
DescriptionSentrin-specific protease 2
Chromosome3
Location3q27.2 (185300284 ~ 185351339) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 3
2014-09-19protein level
1 46 3
2014-05-27protein level
1 46 3
2014-02-25protein level
1 45 3
2013-12-09protein level
1 38 3
2013-11-01protein level
1 34 3
2013-09-12protein level
1 34 3
2013-08-17protein level
1 34 3
2013-07-15protein level
1 23 3
2013-06-11protein level
1 23 3
2013-02-12protein level
1 10 2
2012-12-20protein level
1 11 2
2012-10-30protein level
1 15 2
2012-10-07protein level
1 15 2
2012-08-24protein level
1 14 2
2012-07-28protein level
1 14 2
2012-06-08protein level
1 16 2
2012-05-07protein level
1 12 2
2012-04-10protein level
1 12 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HC62-1
1 24 0 67811.488
NX_Q9HC62-2
1 24 0 66316.2466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714881,EBI-474067 SUMO3  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.SUMO transferase activity .extracellular exosome
.PML body
.cytoplasm
  + 3 more...
2 EBI-714881,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
3 EBI-714881,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
4 EBI-714881,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
5 EBI-714881,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
6 EBI-714881,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
7 EBI-714881,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
8 EBI-714881,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
9 EBI-714881,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland182
ascites150
bladder33
blood16
bone55
brain60
cervix123
connective tissue33
embryonic tissue51
esophagus49
eye43
heart22
intestine30
kidney90
larynx85
liver24
lung50
lymph22
lymph node33
mammary gland92
mouth241
muscle9
ovary29
pancreas23
pharynx73
placenta35
prostate68
skin66
spleen56
testis156
thymus87
thyroid21
trachea38
umbilical cord72
uterus34
vascular77
Health State
TissuesTPM*
normal49
adrenal tumor79
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma48
colorectal tumor44
esophageal tumor57
gastrointestinal tumor50
germ cell tumor75
glioma74
head and neck tumor156
kidney tumor58
leukemia10
liver tumor41
lung tumor19
lymphoma55
non-neoplasia62
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer67
retinoblastoma43
skin tumor79
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult52
blastocyst97
neonate32
fetus52
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland15.9
appendix12.7
bone marrow17.4
cerebral cortex22.9
colon15.4
duodenum12.4
esophagus19.1
gallbladder16.4
heart muscle17.1
kidney14.6
liver12.4
lung13.9
lymph node14.9
ovary24.8
pancreas8.4
placenta21.2
prostate13.9
salivary gland12.9
skin12
small intestine13.5
spleen12
stomach13.9
testis69.2
thyroid gland22.1
urinary bladder17.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608261, gene) Sentrin-specific protease family, member 2; SENP2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center