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> Protein (NX_Q9HC98)
Protein (NX_Q9HC98)
Protein
Gene SymbolNEK6 to neXtProt (NX_Q9HC98)
DescriptionSerine/threonine-protein kinase Nek6
Chromosome9
Location9q33.3 (127019885 ~ 127115586) to Ensembl
Sequene Features : Isoforms 4, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 32 4
2014-09-19protein level
4 23 4
2014-05-27protein level
4 23 5
2014-02-25protein level
4 23 5
2013-12-09protein level
4 19 5
2013-11-01protein level
4 19 5
2013-09-12protein level
4 19 5
2013-08-17protein level
4 19 5
2013-07-15protein level
4 11 4
2013-06-11protein level
4 11 4
2013-02-12protein level
4 9 32
2012-12-20protein level
4 9 32
2012-10-30protein level
4 11 32
2012-10-07protein level
4 11 8
2012-08-24protein level
4 10 8
2012-07-28protein level
4 10 8
2012-06-08protein level
4 14 8
2012-05-07protein level
4 9 8
2012-04-10protein level
4 9 8
2012-01-13protein level
4 6 8
2011-12-20protein level
4 6 8
2011-11-11protein level
4 6 8
2011-08-23protein level
1 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HC98-1
0 13 4 35690.7678
NX_Q9HC98-2
2 13 4 39817.9134
NX_Q9HC98-3
0 13 4 37797.9606
NX_Q9HC98-4
2 13 4 38435.1019
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740364,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-740364,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-740364,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-740364,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-740364,EBI-603457 TNK2  
  .regulation of clathrin-mediated endocytosis
.positive regulation of peptidyl-tyrosine phosphorylation
.innate immune response
  + 10 more...
.hormone receptor binding
.WW domain binding
.metal ion binding
  + 8 more...
.Grb2-EGFR complex
.neuronal cell body
.extrinsic component of cytoplasmic side of plasma membrane
  + 12 more...
6 EBI-740364,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
7 EBI-740364,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
8 EBI-740364,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
9 EBI-740364,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
10 EBI-740364,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-740364,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
12 EBI-740364,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-740364,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
14 EBI-740364,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
15 EBI-740364,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
16 EBI-740364,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
17 EBI-740364,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites175
blood106
bone139
bone marrow41
brain26
cervix61
connective tissue20
embryonic tissue9
eye62
heart33
intestine64
kidney99
liver63
lung65
lymph112
lymph node144
mammary gland52
mouth15
muscle28
nerve64
ovary29
pancreas46
pharynx24
placenta81
prostate42
salivary gland49
skin56
spleen18
stomach62
testis27
thyroid42
tonsil235
trachea19
umbilical cord217
uterus47
vascular58
Health State
TissuesTPM*
normal54
breast (mammary gland) tumor53
chondrosarcoma120
colorectal tumor88
gastrointestinal tumor101
germ cell tumor22
glioma65
head and neck tumor29
kidney tumor130
leukemia84
liver tumor62
lung tumor77
lymphoma69
non-neoplasia103
ovarian tumor26
pancreatic tumor95
primitive neuroectodermal tumor of the CNS31
prostate cancer67
skin tumor55
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult66
embryoid body28
neonate225
fetus59
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland5.8
appendix29.6
bone marrow10.6
cerebral cortex17.5
colon21.6
duodenum15.7
esophagus7.4
gallbladder26.4
heart muscle5.7
kidney16.6
liver28.7
lung17.4
lymph node24.9
ovary8.2
pancreas8.4
placenta28.4
prostate17.3
salivary gland13.8
skin3
small intestine22.1
spleen13.7
stomach25.2
testis8
thyroid gland6.9
urinary bladder25.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604884, gene) Never in mitosis gene a-related kinase 6; NEK6OMIM


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