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> Protein (NX_Q9HCE7)
Protein (NX_Q9HCE7)
Protein
Gene SymbolSMURF1 to neXtProt (NX_Q9HCE7)
DescriptionE3 ubiquitin-protein ligase SMURF1
Chromosome7
Location7q22.1 (98625061 ~ 98741723) to Ensembl
Sequene Features : Isoforms 2, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of dendrite extension
.activation of mitophagy in response to mitochondrial depolarization
  + 18 more...
.R-SMAD binding
.I-SMAD binding
.ubiquitin protein ligase activity
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 59 2
2014-09-19protein level
2 44 2
2014-05-27protein level
2 44 2
2014-02-25protein level
2 44 2
2013-12-09protein level
2 37 2
2013-11-01protein level
2 36 2
2013-09-12protein level
2 36 2
2013-08-17protein level
2 36 2
2013-07-15protein level
2 14 2
2013-06-11protein level
2 14 2
2013-02-12protein level
2 4 4
2012-12-20protein level
2 4 4
2012-10-30protein level
2 6 4
2012-10-07protein level
2 6 2
2012-08-24protein level
2 3 2
2012-07-28protein level
2 3 2
2012-06-08protein level
2 11 2
2012-05-07protein level
2 11 2
2012-04-10protein level
2 11 2
2012-01-13protein level
2 11 2
2011-12-20protein level
2 7 2
2011-11-11protein level
2 7 2
2011-08-23protein level
2 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HCE7-1
1 30 6 86059.3107
NX_Q9HCE7-2
0 30 6 83387.042
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9845742,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
2 EBI-976466,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
3 EBI-9845742,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
4 EBI-9845742,EBI-602647 RHOB  
  .cellular response to ionizing radiation
.cellular response to hydrogen peroxide
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.cleavage furrow
.late endosome membrane
  + 6 more...
5 EBI-976466,EBI-1567153 SMAD1  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.positive regulation of cartilage development
  + 28 more...
.I-SMAD binding
.co-SMAD binding
.metal ion binding
  + 8 more...
.protein complex
.integral component of membrane
.cytosol
  + 6 more...
6 EBI-9845742,EBI-949945 PLEKHO1  
  .N/A .N/A .plasma membrane
.cytoplasm
.nucleus
7 EBI-9845742,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
8 EBI-9845742,EBI-389787 ING2  
  .regulation of response to DNA damage stimulus
.regulation of cellular senescence
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 15 more...
.phosphatidylinositol binding
.methylated histone binding
.protein complex binding
  + 3 more...
.CCAAT-binding factor complex
.Sin3 complex
.Golgi apparatus
  + 3 more...
9 EBI-976466,EBI-6144096 FBXL15  
  .SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.positive regulation of BMP signaling pathway
.bone mineralization
  + 3 more...
.N/A .SCF ubiquitin ligase complex
.cytoplasm
10 EBI-9845742,EBI-9846663 KLF2  
  .cellular response to peptide
.cellular response to laminar fluid shear stress
.cellular response to cycloheximide
  + 14 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder33
blood40
bone13
bone marrow20
brain27
cervix20
connective tissue6
ear62
embryonic tissue51
esophagus49
eye38
heart22
intestine43
kidney42
larynx42
liver19
lung32
lymph22
lymph node66
mammary gland46
mouth45
muscle9
nerve64
ovary49
pancreas46
placenta28
prostate15
skin61
spleen18
stomach62
testis91
thymus25
trachea77
uterus30
Health State
TissuesTPM*
normal32
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma12
colorectal tumor62
esophageal tumor57
gastrointestinal tumor67
germ cell tumor75
glioma83
head and neck tumor29
kidney tumor14
leukemia74
liver tumor20
lung tumor87
lymphoma41
non-neoplasia31
ovarian tumor78
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult44
embryoid body42
blastocyst81
neonate32
fetus34
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11
adrenal gland10
appendix9.8
bone marrow14.1
cerebral cortex8.9
colon9.7
duodenum7.6
esophagus16.6
gallbladder12.9
heart muscle5.7
kidney7.5
liver5.1
lung14.6
lymph node7.9
ovary13.7
pancreas7.8
placenta12.8
prostate7.4
salivary gland6
skin12.9
small intestine7.9
spleen7.4
stomach17.3
testis28.6
thyroid gland5.9
urinary bladder11.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605568, gene) Smad-specific e3 ubiquitin protein ligase 1; SMURF1OMIM


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