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> Protein (NX_Q9HCJ0)
Protein (NX_Q9HCJ0)
Protein
Gene SymbolTNRC6C to neXtProt (NX_Q9HCJ0)
DescriptionTrinucleotide repeat-containing gene 6C protein
Chromosome17
Location17q25.3 (76000249 ~ 76104916) to Ensembl
Sequene Features : Isoforms 2, Variants 149, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 149 5
2014-09-19protein level
2 103 5
2014-05-27protein level
2 103 5
2014-02-25protein level
2 103 4
2013-12-09protein level
2 63 4
2013-11-01protein level
2 63 4
2013-09-12protein level
2 63 4
2013-08-17protein level
2 63 4
2013-07-15protein level
2 41 4
2013-06-11protein level
2 41 4
2013-02-12protein level
2 21 4
2012-12-20protein level
2 16 4
2012-10-30protein level
2 29 4
2012-10-07protein level
2 29 2
2012-08-24protein level
2 28 2
2012-07-28protein level
2 28 2
2012-06-08protein level
2 8 2
2012-05-07protein level
2 8 2
2012-04-10protein level
2 8 2
2012-01-13protein level
2 8 2
2011-12-20protein level
2 8 2
2011-11-11protein level
2 8 2
2011-08-23protein level
2 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HCJ0-1
2 69 1 175856.2184
NX_Q9HCJ0-2
2 69 1 179210.7148
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6507625,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-6507625,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
3 EBI-6507625,EBI-2513054 PAN3  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 4 more...
.metal ion binding
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.PAN complex
.cytosol
.cytoplasmic mRNA processing body
4 EBI-6507625,EBI-743033 CNOT2  
  .regulation of stem cell maintenance
.RNA phosphodiester bond hydrolysis, exonucleolytic
.negative regulation of intracellular estrogen receptor signaling pathway
  + 10 more...
.RNA polymerase II transcription corepressor binding
.RNA polymerase II transcription cofactor activity
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
5 EBI-6507625,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
6 EBI-6507625,EBI-2104530 CNOT6  
  .positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
.RNA phosphodiester bond hydrolysis, exonucleolytic
.nuclear-transcribed mRNA catabolic process, no-go decay
  + 10 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.exoribonuclease activity
.RNA binding
.CCR4-NOT complex
.membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood16
bone55
brain44
connective tissue6
ear62
embryonic tissue4
eye86
heart33
intestine38
kidney28
larynx127
liver4
lung41
lymph node278
mammary gland19
muscle9
nerve64
ovary9
pancreas28
parathyroid97
placenta10
prostate21
skin9
spleen18
testis20
thymus25
trachea38
uterus17
vascular19
Health State
TissuesTPM*
normal46
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor8
germ cell tumor30
glioma37
head and neck tumor22
kidney tumor14
leukemia10
lung tumor9
lymphoma13
non-neoplasia41
ovarian tumor13
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer28
retinoblastoma21
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult32
blastocyst16
fetus62
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.5
adrenal gland3.4
appendix4.3
bone marrow2
cerebral cortex10.2
colon2.9
duodenum1.7
esophagus2.8
gallbladder4
heart muscle4.8
kidney3.5
liver2.1
lung4
lymph node5.8
ovary8
pancreas2.5
placenta1.3
prostate5.7
salivary gland4.8
skin2.7
small intestine2.1
spleen5.8
stomach3.6
testis10.6
thyroid gland3.9
urinary bladder3.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610741, gene) Trinucleotide repeat-containing gene 6c; TNRC6COMIM


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