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Protein |
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Gene Symbol | TNRC6C to neXtProt (NX_Q9HCJ0) |
Description | Trinucleotide repeat-containing gene 6C protein |
Chromosome | 17 |
Location | 17q25.3 (76000249 ~ 76104916) to Ensembl |
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Sequene Features : Isoforms 2, Variants 149, PTMs 5 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .regulation of gene silencing by miRNA .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening + 13 more... |
.RNA binding .nucleotide binding |
.cytosol |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 149 |
| 5 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 103 |
| 5 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 103 |
| 5 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 103 |
| 4 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 63 |
| 4 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 63 |
| 4 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 63 |
| 4 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 63 |
| 4 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 41 |
| 4 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 41 |
| 4 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 21 |
| 4 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 16 |
| 4 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 29 |
| 4 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 29 |
| 2 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 28 |
| 2 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 28 |
| 2 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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2011-08-23 | | protein level | | | | | | | 2 |
| 8 |
| 2 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-6507625,EBI-1222758 |
CNOT1 |
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.regulation of stem cell maintenance .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .RNA phosphodiester bond hydrolysis, exonucleolytic + 13 more... |
.armadillo repeat domain binding .poly(A) RNA binding .retinoic acid receptor binding + 3 more... |
.CCR4-NOT complex .membrane .cytosol + 4 more... |
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2 |
EBI-6507625,EBI-81531 |
PABPC1 |
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.negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening + 12 more... |
.poly(A) RNA binding .translation activator activity .poly(U) RNA binding + 4 more... |
.catalytic step 2 spliceosome .extracellular exosome .cytoplasmic ribonucleoprotein granule + 7 more... |
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3 |
EBI-6507625,EBI-2513054 |
PAN3 |
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.RNA phosphodiester bond hydrolysis, exonucleolytic .positive regulation of cytoplasmic mRNA processing body assembly .gene expression + 4 more... |
.metal ion binding .transferase activity, transferring phosphorus-containing groups .ATP binding |
.PAN complex .cytosol .cytoplasmic mRNA processing body |
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4 |
EBI-6507625,EBI-743033 |
CNOT2 |
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.regulation of stem cell maintenance .RNA phosphodiester bond hydrolysis, exonucleolytic .negative regulation of intracellular estrogen receptor signaling pathway + 10 more... |
.RNA polymerase II transcription corepressor binding .RNA polymerase II transcription cofactor activity |
.CCR4-NOT complex .membrane .cytosol + 2 more... |
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5 |
EBI-6507625,EBI-528269 |
AGO2 |
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.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .mRNA cleavage involved in gene silencing by siRNA .RNA phosphodiester bond hydrolysis, endonucleolytic + 25 more... |
.endoribonuclease activity, cleaving miRNA-paired mRNA .pre-miRNA binding .endoribonuclease activity, cleaving siRNA-paired mRNA + 12 more... |
.RISC-loading complex .micro-ribonucleoprotein complex .ribonucleoprotein complex + 9 more... |
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6 |
EBI-6507625,EBI-2104530 |
CNOT6 |
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.positive regulation of ligand-dependent nuclear receptor transcription coactivator activity .RNA phosphodiester bond hydrolysis, exonucleolytic .nuclear-transcribed mRNA catabolic process, no-go decay + 10 more... |
.metal ion binding .poly(A)-specific ribonuclease activity .exoribonuclease activity .RNA binding |
.CCR4-NOT complex .membrane .cytosol .nucleus |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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adrenal gland | 30 | |
bladder | 33 | |
blood | 16 | |
bone | 55 | |
brain | 44 | |
connective tissue | 6 | |
ear | 62 | |
embryonic tissue | 4 | |
eye | 86 | |
heart | 33 | |
intestine | 38 | |
kidney | 28 | |
larynx | 127 | |
liver | 4 | |
lung | 41 | |
lymph node | 278 | |
mammary gland | 19 | |
muscle | 9 | |
nerve | 64 | |
ovary | 9 | |
pancreas | 28 | |
parathyroid | 97 | |
placenta | 10 | |
prostate | 21 | |
skin | 9 | |
spleen | 18 | |
testis | 20 | |
thymus | 25 | |
trachea | 38 | |
uterus | 17 | |
vascular | 19 | |
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Health State | |
Tissues | TPM* | |
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normal | 46 | |
adrenal tumor | 79 | |
bladder carcinoma | 56 | |
breast (mammary gland) tumor | 21 | |
chondrosarcoma | 24 | |
colorectal tumor | 17 | |
gastrointestinal tumor | 8 | |
germ cell tumor | 30 | |
glioma | 37 | |
head and neck tumor | 22 | |
kidney tumor | 14 | |
leukemia | 10 | |
lung tumor | 9 | |
lymphoma | 13 | |
non-neoplasia | 41 | |
ovarian tumor | 13 | |
pancreatic tumor | 57 | |
primitive neuroectodermal tumor of the CNS | 23 | |
prostate cancer | 28 | |
retinoblastoma | 21 | |
soft tissue/muscle tissue tumor | 15 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 32 | |
blastocyst | 16 | |
fetus | 62 | |
juvenile | 17 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 4.5 | |
adrenal gland | 3.4 | |
appendix | 4.3 | |
bone marrow | 2 | |
cerebral cortex | 10.2 | |
colon | 2.9 | |
duodenum | 1.7 | |
esophagus | 2.8 | |
gallbladder | 4 | |
heart muscle | 4.8 | |
kidney | 3.5 | |
liver | 2.1 | |
lung | 4 | |
lymph node | 5.8 | |
ovary | 8 | |
pancreas | 2.5 | |
placenta | 1.3 | |
prostate | 5.7 | |
salivary gland | 4.8 | |
skin | 2.7 | |
small intestine | 2.1 | |
spleen | 5.8 | |
stomach | 3.6 | |
testis | 10.6 | |
thyroid gland | 3.9 | |
urinary bladder | 3.1 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*610741, gene) Trinucleotide repeat-containing gene 6c; TNRC6C | OMIM |
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