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	> Protein (NX_Q9HCJ0) Protein (NX_Q9HCJ0) Protein Gene Symbol TNRC6C to neXtProt (NX_Q9HCJ0) Description Trinucleotide repeat-containing gene 6C protein Chromosome 17 Location 17q25.3 (76000249 ~ 76104916) to Ensembl Sequene Features : Isoforms 2, Variants 149, PTMs 5 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .regulation of gene silencing by miRNA .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening   + 13 more... .RNA binding .nucleotide binding .cytosol Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 149 5 2014-09-19 protein level 2 103 5 2014-05-27 protein level 2 103 5 2014-02-25 protein level 2 103 4 2013-12-09 protein level 2 63 4 2013-11-01 protein level 2 63 4 2013-09-12 protein level 2 63 4 2013-08-17 protein level 2 63 4 2013-07-15 protein level 2 41 4 2013-06-11 protein level 2 41 4 2013-02-12 protein level 2 21 4 2012-12-20 protein level 2 16 4 2012-10-30 protein level 2 29 4 2012-10-07 protein level 2 29 2 2012-08-24 protein level 2 28 2 2012-07-28 protein level 2 28 2 2012-06-08 protein level 2 8 2 2012-05-07 protein level 2 8 2 2012-04-10 protein level 2 8 2 2012-01-13 protein level 2 8 2 2011-12-20 protein level 2 8 2 2011-11-11 protein level 2 8 2 2011-08-23 protein level 2 8 2 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q9HCJ0-1 2 69 1 175856.2184 NX_Q9HCJ0-2 2 69 1 179210.7148 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-6507625,EBI-1222758 CNOT1     .regulation of stem cell maintenance .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .RNA phosphodiester bond hydrolysis, exonucleolytic   + 13 more... .armadillo repeat domain binding .poly(A) RNA binding .retinoic acid receptor binding   + 3 more... .CCR4-NOT complex .membrane .cytosol   + 4 more... 2 EBI-6507625,EBI-81531 PABPC1     .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening   + 12 more... .poly(A) RNA binding .translation activator activity .poly(U) RNA binding   + 4 more... .catalytic step 2 spliceosome .extracellular exosome .cytoplasmic ribonucleoprotein granule   + 7 more... 3 EBI-6507625,EBI-2513054 PAN3     .RNA phosphodiester bond hydrolysis, exonucleolytic .positive regulation of cytoplasmic mRNA processing body assembly .gene expression   + 4 more... .metal ion binding .transferase activity, transferring phosphorus-containing groups .ATP binding .PAN complex .cytosol .cytoplasmic mRNA processing body 4 EBI-6507625,EBI-743033 CNOT2     .regulation of stem cell maintenance .RNA phosphodiester bond hydrolysis, exonucleolytic .negative regulation of intracellular estrogen receptor signaling pathway   + 10 more... .RNA polymerase II transcription corepressor binding .RNA polymerase II transcription cofactor activity .CCR4-NOT complex .membrane .cytosol   + 2 more... 5 EBI-6507625,EBI-528269 AGO2     .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .mRNA cleavage involved in gene silencing by siRNA .RNA phosphodiester bond hydrolysis, endonucleolytic   + 25 more... .endoribonuclease activity, cleaving miRNA-paired mRNA .pre-miRNA binding .endoribonuclease activity, cleaving siRNA-paired mRNA   + 12 more... .RISC-loading complex .micro-ribonucleoprotein complex .ribonucleoprotein complex   + 9 more... 6 EBI-6507625,EBI-2104530 CNOT6     .positive regulation of ligand-dependent nuclear receptor transcription coactivator activity .RNA phosphodiester bond hydrolysis, exonucleolytic .nuclear-transcribed mRNA catabolic process, no-go decay   + 10 more... .metal ion binding .poly(A)-specific ribonuclease activity .exoribonuclease activity .RNA binding .CCR4-NOT complex .membrane .cytosol .nucleus EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adrenal gland 30 bladder 33 blood 16 bone 55 brain 44 connective tissue 6 ear 62 embryonic tissue 4 eye 86 heart 33 intestine 38 kidney 28 larynx 127 liver 4 lung 41 lymph node 278 mammary gland 19 muscle 9 nerve 64 ovary 9 pancreas 28 parathyroid 97 placenta 10 prostate 21 skin 9 spleen 18 testis 20 thymus 25 trachea 38 uterus 17 vascular 19 Health State Tissues TPM* normal 46 adrenal tumor 79 bladder carcinoma 56 breast (mammary gland) tumor 21 chondrosarcoma 24 colorectal tumor 17 gastrointestinal tumor 8 germ cell tumor 30 glioma 37 head and neck tumor 22 kidney tumor 14 leukemia 10 lung tumor 9 lymphoma 13 non-neoplasia 41 ovarian tumor 13 pancreatic tumor 57 primitive neuroectodermal tumor of the CNS 23 prostate cancer 28 retinoblastoma 21 soft tissue/muscle tissue tumor 15 Developmental Stage Tissues TPM* adult 32 blastocyst 16 fetus 62 juvenile 17 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 4.5 adrenal gland 3.4 appendix 4.3 bone marrow 2 cerebral cortex 10.2 colon 2.9 duodenum 1.7 esophagus 2.8 gallbladder 4 heart muscle 4.8 kidney 3.5 liver 2.1 lung 4 lymph node 5.8 ovary 8 pancreas 2.5 placenta 1.3 prostate 5.7 salivary gland 4.8 skin 2.7 small intestine 2.1 spleen 5.8 stomach 3.6 testis 10.6 thyroid gland 3.9 urinary bladder 3.1 Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*610741, gene) Trinucleotide repeat-containing gene 6c; TNRC6C OMIM

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