Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9HCM9)
Protein (NX_Q9HCM9)
Protein
Gene SymbolTRIM39 to neXtProt (NX_Q9HCM9)
DescriptionE3 ubiquitin-protein ligase TRIM39
Chromosome6
Location6p22.1 (30294256 ~ 30311506) to Ensembl
Sequene Features : Isoforms 2, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 56 1
2014-09-19protein level
2 37 1
2014-05-27protein level
2 37 1
2014-02-25protein level
2 10 1
2013-12-09protein level
2 6 1
2013-11-01protein level
2 6 0
2013-09-12protein level
2 6 0
2013-08-17protein level
2 6 0
2013-07-15protein level
2 6 0
2013-06-11protein level
2 6 0
2013-02-12protein level
2 6 2
2012-12-20protein level
2 7 2
2012-10-30protein level
2 7 2
2012-10-07protein level
2 7 1
2012-08-24protein level
2 7 1
2012-07-28protein level
2 7 1
2012-06-08protein level
2 12 1
2012-05-07protein level
2 12 1
2012-04-10protein level
2 9 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HCM9-1
1 22 1 59652.4962
NX_Q9HCM9-2
0 22 1 56338.6506
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739510,EBI-10173195 SMCO3  
  .N/A .N/A .integral component of membrane
2 EBI-739510,EBI-750973 PSMD9  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 26 more...
.bHLH transcription factor binding
.transcription coactivator activity
.proteasome regulatory particle
.cytosol
.cytoplasm
  + 2 more...
3 EBI-739510,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
4 EBI-739510,EBI-744322 PRPF3  
  .RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
.Cajal body
  + 4 more...
5 EBI-739510,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
6 EBI-739510,EBI-2841331 ZNF26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-739510,EBI-81290 TRIM21  
  .negative regulation of viral release from host cell
.negative regulation of protein deubiquitination
.protein trimerization
  + 16 more...
.identical protein binding
.ligase activity
.zinc ion binding
  + 3 more...
.ribonucleoprotein complex
.cytosol
.cytoplasm
  + 3 more...
8 EBI-739510,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
9 EBI-739510,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
10 EBI-739510,EBI-357793 PSMA6  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
11 EBI-739510,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
12 EBI-739510,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
13 EBI-739510,EBI-1058647 UBXN1  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of proteasomal ubiquitin-dependent protein catabolic process
.negative regulation of protein ubiquitination
.K6-linked polyubiquitin binding
.ATPase binding
.ubiquitin binding
  + 2 more...
.neuronal cell body
.Cdc48p-Npl4p-Ufd1p AAA ATPase complex
.dendrite
  + 2 more...
14 EBI-739510,EBI-73473 EIF4A2  
  .negative regulation of RNA-directed RNA polymerase activity
.cellular protein metabolic process
.cytokine-mediated signaling pathway
  + 8 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
  + 3 more...
.perinuclear region of cytoplasm
.eukaryotic translation initiation factor 4F complex
.cytosol
.nucleolus
15 EBI-739510,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
16 EBI-739510,EBI-8636434 TTC32  
  .N/A .N/A .N/A
17 EBI-739510,EBI-10264625 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
18 EBI-739510,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
19 EBI-739510,EBI-2818641 ZKSCAN4  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
20 EBI-739510,EBI-348496 UBE2E3  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.regulation of growth
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
21 EBI-739510,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
22 EBI-739510,EBI-2129763 UBE2E2  
  .positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
23 EBI-739510,EBI-1044504 LXN  
  .detection of temperature stimulus involved in sensory perception of pain
.inflammatory response
.heparin binding
.metalloendopeptidase inhibitor activity
.extracellular exosome
.cytoplasm
24 EBI-739510,EBI-749370 UBAC1  
  .protein ubiquitination .N/A .extracellular exosome
.plasma membrane
.Golgi apparatus
.cytoplasm
25 EBI-739510,EBI-394640 MED18  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
26 EBI-739510,EBI-1993899 UBXN6  
  .N/A .N/A .extracellular exosome
.microtubule organizing center
.cytoplasm
  + 2 more...
27 EBI-739510,EBI-745871 UBTD1  
  .N/A .N/A .N/A
28 EBI-739510,EBI-741774 POLI  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
29 EBI-739510,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
30 EBI-739510,EBI-743894 TRIM17  
  .protein autoubiquitination .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood57
bone13
brain28
cervix61
connective tissue20
embryonic tissue28
eye38
heart22
intestine21
kidney23
lung23
lymph node44
mammary gland13
muscle18
pancreas14
pharynx24
pituitary gland60
placenta3
prostate26
skin47
stomach20
testis78
thymus25
thyroid150
uterus25
vascular38
Health State
TissuesTPM*
normal27
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor16
germ cell tumor34
glioma65
head and neck tumor52
kidney tumor14
leukemia52
lung tumor19
non-neoplasia20
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult20
embryoid body14
blastocyst65
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland6.9
appendix10.2
bone marrow10.3
cerebral cortex6.2
colon6.8
duodenum7
esophagus10
gallbladder8.3
heart muscle6.9
kidney8.9
liver4.3
lung9.7
lymph node10.3
ovary11.5
pancreas4.3
placenta7.1
prostate8.3
salivary gland6.3
skin5.9
small intestine6.8
spleen10.5
stomach6.6
testis22.6
thyroid gland13.2
urinary bladder8.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605700, gene) Tripartite motif-containing protein 39; TRIM39OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center