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> Protein (NX_Q9HCU9)
Protein (NX_Q9HCU9)
Protein
Gene SymbolBRMS1 to neXtProt (NX_Q9HCU9)
DescriptionBreast cancer metastasis-suppressor 1
Chromosome11
Location11q13.2 (66104804 ~ 66112596) to Ensembl
Sequene Features : Isoforms 1, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 30 2
2014-09-19protein level
1 25 2
2014-05-27protein level
1 25 2
2014-02-25protein level
1 25 2
2013-12-09protein level
1 18 2
2013-11-01protein level
1 17 2
2013-09-12protein level
1 17 2
2013-08-17protein level
1 17 2
2013-07-15protein level
1 9 1
2013-06-11protein level
1 9 1
2013-02-12protein level
1 6 1
2012-12-20protein level
1 6 1
2012-10-30protein level
1 6 1
2012-10-07protein level
1 6 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 3 1
2012-05-07protein level
1 3 1
2012-04-10protein level
1 3 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9HCU9-1
13 0 0 28442.9587
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714781,EBI-1053164 DNAJB6  
  .regulation of cellular response to heat
.negative regulation of inclusion body assembly
.chorion development
  + 11 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.membrane
  + 4 more...
2 EBI-714781,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
3 EBI-714781,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
4 EBI-714781,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
5 EBI-714781,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
6 EBI-714781,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
7 EBI-714781,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
8 EBI-714781,EBI-540496 SUDS3  
  .negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.positive regulation of apoptotic process
  + 8 more...
.histone deacetylase binding
.enzyme binding
.Sin3-type complex
.Sin3 complex
.cytoplasm
  + 2 more...
9 EBI-714781,EBI-301697 HDAC6  
  .positive regulation of hydrogen peroxide-mediated programmed cell death
.tubulin deacetylation
.positive regulation of chaperone-mediated protein complex assembly
  + 38 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.dynein complex binding
.Hsp90 protein binding
  + 16 more...
.perinuclear region of cytoplasm
.perikaryon
.cell leading edge
  + 13 more...
10 EBI-714781,EBI-715576 HDAC5  
  .negative regulation of cell migration involved in sprouting angiogenesis
.positive regulation of sequence-specific DNA binding transcription factor activity
.regulation of skeletal muscle fiber development
  + 25 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.nuclear body
.cytosol
.Golgi apparatus
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites75
bladder33
blood57
bone69
bone marrow20
brain25
cervix41
connective tissue6
embryonic tissue51
esophagus49
eye33
intestine30
kidney28
larynx170
liver29
lung62
lymph67
lymph node11
mammary gland26
muscle47
ovary39
pancreas18
placenta52
prostate21
salivary gland98
skin56
spleen56
stomach41
testis6
tonsil117
uterus56
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma60
colorectal tumor26
esophageal tumor57
gastrointestinal tumor50
germ cell tumor34
glioma65
head and neck tumor44
kidney tumor87
leukemia52
liver tumor62
lung tumor145
lymphoma41
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma21
skin tumor79
soft tissue/muscle tissue tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body57
blastocyst81
fetus23
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.6
adrenal gland16.6
appendix26.2
bone marrow35.8
cerebral cortex11.9
colon24.2
duodenum21.5
esophagus20.7
gallbladder19.3
heart muscle12.3
kidney23.5
liver9.4
lung22.6
lymph node31.4
ovary13.5
pancreas14.3
placenta19.8
prostate21
salivary gland21.5
skin26.7
small intestine21.4
spleen25.3
stomach22.7
testis25.6
thyroid gland21.9
urinary bladder22.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606259, gene) Breast cancer metastasis suppressor 1; BRMS1OMIM


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