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> Protein (NX_Q9NP31)
Protein (NX_Q9NP31)
Protein
Gene SymbolSH2D2A to neXtProt (NX_Q9NP31)
DescriptionSH2 domain-containing protein 2A
Chromosome1
Location1q23.1 (156776035 ~ 156786654) to Ensembl
Sequene Features : Isoforms 4, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 56 2
2014-09-19protein level
4 40 2
2014-05-27protein level
4 40 2
2014-02-25protein level
4 38 2
2013-12-09protein level
4 26 2
2013-11-01protein level
4 25 2
2013-09-12protein level
4 25 2
2013-08-17protein level
4 25 2
2013-07-15protein level
4 17 2
2013-06-11protein level
4 17 2
2013-02-12protein level
3 6 15
2012-12-20protein level
3 6 15
2012-10-30protein level
3 7 15
2012-10-07protein level
3 7 5
2012-08-24protein level
3 6 5
2012-07-28protein level
3 6 5
2012-06-08protein level
3 7 5
2012-05-07protein level
3 7 5
2012-04-10protein level
3 7 5
2012-01-13protein level
3 6 5
2011-12-20protein level
3 6 5
2011-11-11protein level
3 6 5
2011-08-23protein level
3 6 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NP31-1
0 19 0 42907.5901
NX_Q9NP31-2
1 19 0 44050.2537
NX_Q9NP31-3
0 18 0 39821.1465
NX_Q9NP31-4
1 18 0 40928.6343
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-490630,EBI-10696047 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
2 EBI-490630,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-490630,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
4 EBI-490630,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-490630,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
6 EBI-490630,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
7 EBI-490630,EBI-9090282 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
8 EBI-490630,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
9 EBI-490630,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
10 EBI-490630,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
11 EBI-490630,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
12 EBI-490630,EBI-10694873 DCAF12L1  
  .N/A .N/A .N/A
13 EBI-490630,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
14 EBI-490630,EBI-752030 FAM46B  
  .N/A .N/A .N/A
15 EBI-490630,EBI-954084 FAM46A  
  .regulation of blood coagulation
.regulation of gene expression
.poly(A) RNA binding .N/A
16 EBI-490630,EBI-9089825 PLEKHB1  
  .regulation of cell differentiation
.phototransduction
.multicellular organismal development
.signal transducer activity .integral component of membrane
.cytoplasm
17 EBI-490630,EBI-2875625 ASB3  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood163
embryonic tissue4
eye19
intestine25
kidney9
liver9
lung23
lymph node22
ovary9
pancreas14
placenta3
spleen56
stomach73
testis2
thymus87
Health State
TissuesTPM*
normal16
bladder carcinoma56
colorectal tumor17
gastrointestinal tumor16
germ cell tumor7
leukemia31
lung tumor77
non-neoplasia20
pancreatic tumor28
retinoblastoma43
Developmental Stage
TissuesTPM*
adult17
blastocyst16
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
appendix10.9
bone marrow2.3
colon2.3
duodenum1.9
gallbladder3
liver1.2
lung3.4
lymph node7.1
small intestine2.3
spleen6.2
stomach2.9
urinary bladder4.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604514, gene) Sh2 domain protein 2a; SH2D2AOMIM


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